Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 吴浩强教授 (病理解剖及细胞学系) |
| 潘伟生教授 (外科学系) |
| 李嘉慧博士 (药剂学院) |
| 陈家贤博士 (病理解剖及细胞学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1038/modpathol.2014.94 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/16WOS source URL
其它资讯
摘要Recurrent mutations in the promoter region of telomerase reverse transcriptase (TERT) have been found in various cancers including diffuse gliomas. Mutations lead to TERT upregulation and are associated with aggressive clinical behavior in glioblastomas. However, the clinical significance of TERT promoter mutations in lower-grade gliomas remains undetermined. The aim of this study is to evaluate the status of TERT promoter and the respective prognostic significance in a cohort of 237 lower-grade gliomas comprising grades II and III astrocytomas, oligodendrogliomas, and oligoastrocytomas. Mutually exclusive mutations in TERT promoter, C228T and C250T, were identified in http://aims.cuhk.edu.hk/converis/portal/Publication/16/105 (15%) diffuse astrocytomas, http://aims.cuhk.edu.hk/converis/portal/Publication/16/63 (25%) anaplastic astrocytomas, 13/18 (72%) oligodendrogliomas, 3/3 (100%) anaplastic oligodendrogliomas, 17/45 (38%) oligoastrocytomas, and 2/3 (67%) anaplastic oligoastrocytomas. Mutations co-occurred with 1p/19q codeletion (P<0.001) and are associated with oligodendroglial histology (P<0.001). Kaplan-Meier's survival analysis showed that TERT promoter mutation (P=0.037), lsocitrate dehydrogenase (IDH) mutation (P<0.001), and 1p/19q codeletion (P<0.001) were associated with favorable overall survival (OS). In the subset of 1http://aims.cuhk.edu.hk/converis/portal/Publication/16 IDH-mutated lower-grade gliomas lacking 1p/19q codeletion, 19 TEAT promoter-mutated tumors exhibited longer progression-free survival (PFS) (P=0.027) and OS (P=0.004). Consistent with this observation, in the subset of 97 IDH-mutated astrocytomas, 14 TERT promoter-mutated tumors showed longer PFS (P=0.001) and OS (P=0.001). In contrast, among the subset of 74 IDH wild-type lower-grade gliomas with intact 1p/19q, TERT promoter mutation was associated with shorter PFS (P=0.001) and OS (P=0.001). Similarly, in the subset of 65 IDH wild-type astrocytomas, http://aims.cuhk.edu.hk/converis/portal/Publication/16 TERT promoter-mutated tumors exhibited unfavorable PFS (P=0.007) and OS (P=0.008). Our results indicate that when combined with IDH status, TERT promoter mutation contributes to prognostic subgroups of lower-grade astrocytic tumors or 1p/19q intact lower-grade gliomas and this may further refine future molecular classification of lower-grade gliomas.
着者Chan AKY, Yao Y, Zhang ZY, Chung NYF, Liu JSM, Li KKW, Shi ZF, Chan DTM, Poon WS, Zhou LF, Ng HK
期刊名称MODERN PATHOLOGY
出版年份2015
月份2
日期1
卷号28
期次2
出版社NATURE PUBLISHING GROUP
页次177 - 186
国际标準期刊号0893-3952
电子国际标準期刊号1530-0285
语言英式英语
Web of Science 学科类别Pathology
