Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 包立怡教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.lfs.2014.12.019 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/1WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/1Scopus source URL
其它资讯
摘要Aims: Tau is a microtubule-binding protein facilitating the stability of the cytoskeleton. It is important for neurons as several neurodegenerative diseases involve hyperphosphorylation and aggregation of tau. It is known that mutated tau P30http://aims.cuhk.edu.hk/converis/portal/Publication/1L results in aggregation of tau proteins, leading to neuronal loss in the brain. The aim of this study was to investigate the effect of tau mutation on the retina using a transgenic tau P30http://aims.cuhk.edu.hk/converis/portal/Publication/1L mouse model. Main methods: Morphometric analysis was utilized to quantify the neurodegenerative changes, including the thickness of the inner nuclear layer (INL), and the density and size of retinal ganglion cells (RGCs). Sections of retina tissue stained by hematoxylin and eosin (H&E) and immunohistochemistry were analyzed. Comparisons were made between the tau P30http://aims.cuhk.edu.hk/converis/portal/Publication/1L mice and control mice, as well as between different age groups. Key findings: A significant decrease in the thickness of the INL in tau P30http://aims.cuhk.edu.hk/converis/portal/Publication/1L mice was found when compared with that of control mice. The effect was more pronounced in the peripheral area, and the effect increased with age. Regarding density of RGCs, tau P30http://aims.cuhk.edu.hk/converis/portal/Publication/1L mice showed a similar age-related decline as in control mice. Furthermore, the RGCs from tau P30http://aims.cuhk.edu.hk/converis/portal/Publication/1L mice increased in size with age, and the RGCs from control mice decreased in size with age. Significance: Tau may be an age-independent factor of accelerated neurodegeneration, with effects differing by types of neurons and regions of the retina.
着者Ho W.L., Leung Y., Cheng S.S.Y., Lok C.K.M., Ho Y.-S., Baum L., Yang X., Chiu K., Chang R.C.-C.
期刊名称LIFE SCIENCES
出版年份20http://aims.cuhk.edu.hk/converis/portal/Publication/15
月份3
日期http://aims.cuhk.edu.hk/converis/portal/Publication/1
卷号http://aims.cuhk.edu.hk/converis/portal/Publication/124
出版社Elsevier BV
出版地Netherlands
页次http://aims.cuhk.edu.hk/converis/portal/Publication/16 - 23
国际标準期刊号0024-3205
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1879-063http://aims.cuhk.edu.hk/converis/portal/Publication/1
语言英式英语
关键词Aging, Neurodegeneration, Retina, Retinal ganglion cells, Tau
