Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 林革教授 (生物医学学院) |
| 蔡若涓小姐 (生物医学学院) |
| 杜健华教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1021/np500385b |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/9WOS source URL
其它资讯
摘要A new polyoxypregnane aglycone, tenacigenin D (1), and seven new C21 steroid glycosides, tenacissimosides D-J (2-8), were isolated from the stems of Marsdenia tenacissima. Their structures were determined by interpretation of their 1D and 2D NMR and other spectroscopic data, as well as by comparison with published values for related known compounds. Compound 1 was found to circumvent P-glycoprotein (P-gp)-mediated multidrug resistance through an inhibitory effect on P-gp with a similar potency to verapamil. In addition, compound 1 potentiated the activity of erlotinib and gefitinib in epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI)-resistant non-small-cell lung cancer cells.
着者Yao S, To KKW, Wang YZ, Yin C, Tang CP, Chai S, Ke CQ, Lin G, Ye Y
期刊名称Journal of Natural Products
详细描述To ORKTS: TO KK contributed equally as the other first author (Yao S) to the work and he is designated as the co-first author
出版年份2014
月份http://aims.cuhk.edu.hk/converis/portal/Publication/9
日期1
卷号77
期次http://aims.cuhk.edu.hk/converis/portal/Publication/9
出版社AMER CHEMICAL SOC
页次2044 - 2053
国际标準期刊号0163-3864
电子国际标準期刊号1520-6025
语言英式英语
Web of Science 学科类别Chemistry, Medicinal; Pharmacology & Pharmacy; Plant Sciences
