Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 包立怡教授 (药剂学院) |
| 左中教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/epi.12158 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/6WOS source URL
其它资讯
摘要Purpose: Antiepileptic drugs (AEDs) do not effectively treat 30-40% of patients with epilepsy. Export of AEDs by P-glycoprotein (Pgp, ABCB1, or MDR1), which is over-expressed in the blood-brain barrier in drug-resistant patients, may be a mechanism for resistance to AEDs. For most recently approved AEDs, whether they are transported by Pgp is unknown. We investigated whether a new AED, lacosamide (LCM), is a substrate of human Pgp.
着者Zhang CB, Chanteux H, Zuo Z, Kwan P, Baum L
期刊名称EPILEPSIA
出版年份2013
月份7
日期1
卷号54
期次7
出版社WILEY-BLACKWELL
页次1154 - 11http://aims.cuhk.edu.hk/converis/portal/Publication/60
国际标準期刊号0013-9580
电子国际标準期刊号1528-11http://aims.cuhk.edu.hk/converis/portal/Publication/67
语言英式英语
关键词Lacosamide; P-glycoprotein; Transport
Web of Science 学科类别Clinical Neurology; CLINICAL NEUROLOGY; Neurosciences & Neurology
