Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 李嘉慧博士 (药剂学院) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/10WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/10Scopus source URL
其它资讯
摘要Medulloblastoma (MB) is the most common malignant brain tumor in children. Although multimodality treatment regimens including surgery, radiotherapy and chemotherapy have greatly improved disease outcome, about one-third of MB patient remains incurable, and many long-term survivors are suffered from deleterious effects due to aggressive treatment. Understanding the signaling pathways and the genetic mechanisms contributed to MB development would be the key to develop novel therapeutic treatment strategies for improving survival and outcome of MB. In this review, we discuss the biological signaling pathways involved in MB pathogenesis. We also go through the current international consensus of four core MB subgroups namely, SHH, WNT, Group 3, and Group 4. This is adopted based on the knowledge of genomic complexity of MB as analyzed by recent high-throughput genomic technology. We talk about immunohistochemistry assays established to determine molecular subgroup affiliation. In the last part of review, we discuss how identification of molecular subgroups is going to change our routine disease diagnosis and clinical management.
着者Li K.K.-W., Lau K.-M., Ng H.-K.
期刊名称INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
出版年份2013
月份8
日期30
卷号6
期次7
出版社e-Century Publishing Corporation
出版地United States
页次1211 - 1222
国际标準期刊号1936-2625
语言英式英语
关键词Medulloblastoma, Molecular subgroups, Signaling pathway
