Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 陈德威教授 (麻醉及深切治疗学系) |
| Professor Tony GIN (麻醉及深切治疗学系) |
| 王海天教授 (赛马会公共卫生及基层医疗学院) |
| 梁子杏教授 (麻醉及深切治疗学系) |
| 黄维达教授 (麻醉及深切治疗学系) |
| 张琳博士 (生物医学学院) |
| 黄曦教授 (内科及药物治疗学系) |
| 于君教授 (内科及药物治疗学系) |
| 何浩文博士 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1080/15548627.2016.1179410 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/3WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/3Scopus source URL
其它资讯
摘要ABSTRACT: Autophagy is one of the innate immune defense mechanisms against microbial challenges. Previous in vitro and in vivo models of sepsis demonstrated that autophagy was activated initially in sepsis, followed by a subsequent phase of impairment. Autophagy modulation appears to be protective against multiple organ injuries in these murine sepsis models. This is achieved in part by preventing apoptosis, maintaining a balance between the productions of pro- and anti-inflammatory cytokines, and preserving mitochondrial functions. This article aims to discuss the role of autophagy in sepsis and the therapeutic potential of autophagy enhancers.
着者Ho J., Yu J., Wong S.H., Zhang L., Liu X., Wong W.T., Leung C.C.H., Choi G., Wang M.H.T., Gin T., Chan M.T.V., Wu W.K.K.
期刊名称Autophagy
出版年份2016
月份7
日期2
卷号12
期次7
出版社Landes Bioscience
出版地United States
页次107http://aims.cuhk.edu.hk/converis/portal/Publication/3 - 1082
国际标準期刊号1554-8627
电子国际标準期刊号1554-86http://aims.cuhk.edu.hk/converis/portal/Publication/35
语言英式英语
关键词apoptosis, autophagy, immunity, mitochondrial function, sepsis
