Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 陈德威教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/cpr.12252 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/10WOS source URL
其它资讯
摘要Long non-coding RNAs (lncRNAs) compose a group of non-protein-coding RNAs - more than 200 nucleotides in length. Recent studies have shown that lncRNAs play important roles in different cellular processes, including proliferation, differentiation, migration and invasion. Deregulation of lncRNAs has been widely reported in human tumours, in which they are able to function as either oncogenes (on the one hand) or tumour suppressor genes (on the other). Deregulation of CCAT1 (colon cancer-associated transcript-1), an oncogenic lncRNA, has been documented in different types of malignancy, such as gastric cancer, colorectal cancer and hepatocellular carcinoma. In this regard, enforced expression of CCAT1 exerts potent tumorigenic effects by promoting cell proliferation, invasion and migration. Recent evidence has also shown that CCAT1 may serve as a prognostic cancer biomarker. In this review, we provide an overview of current evidence relating to the role and biological function of CCAT1 in tumour development.
着者Xin Y, Li Z, Shen JX, Chan MTV, Wu WKK
期刊名称Cell Proliferation
出版年份2016
月份6
日期1
卷号49
期次3
出版社WILEY-BLACKWELL
页次255 - 260
国际标準期刊号0960-7722
电子国际标準期刊号1365-2184
语言英式英语
Web of Science 学科类别Cell Biology
