Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 陈德威教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1007/s13277-015-4599-0 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
其它资讯
摘要Recent researches have shed new light on the importance of epigenetic alterations, including promoter hypermethylation and microRNA dysregulation, in the initiation and progression of melanoma. The clinical utilization of circulating epigenetic markers in melanoma has also been investigated. In this review, we explored the literature and summarized the latest progress in the discovery of circulating epigenetic markers, namely methylated DNA and microRNAs, for non-invasive diagnosis of melanoma, as well as their measurability and predictability. We also discussed the utility of these epigenetic markers as novel prognostic and predictive markers and their association with melanoma clinical phenotypes, including recurrence and patients' survival. Large-cohort validations are warranted to maximize the clinical utilization of these markers.
着者Xin Y, Li Z, Chan MTV, Wu WKK
期刊名称Tumor Biology
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/016
月份2
日期1
卷号37
期次2
出版社SPRINGER
页次1487 - 1492
国际标準期刊号1http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0-4283
电子国际标準期刊号1423-http://aims.cuhk.edu.hk/converis/portal/Publication/038http://aims.cuhk.edu.hk/converis/portal/Publication/0
语言英式英语
关键词Circulating biomarkers; Epigenetic; Melanoma; miRNA
Web of Science 学科类别Oncology
