Refereed conference paper presented and published in conference proceedings
香港中文大学研究人员 ( 现职)
| 刘晓东博士 (麻醉及深切治疗学系) |
| Professor Tony GIN (麻醉及深切治疗学系) |
| 黄曦教授 (内科及药物治疗学系) |
| 陈德威教授 (麻醉及深切治疗学系) |
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 何浩文博士 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1186/s13054-016-1518-8 |
其它资讯
摘要Accumulating evidence suggests that the intestinal barrier function is impaired during systemic inflammation as in sepsis. Animal models of sepsis revealed several ileal pathological changes. These include epithelial apoptosis, disruption of tight junctions and increased intestinal permeability [1,2]. The impaired gut barrier function may increase the risk of bacterial translocation from the gut lumen to the bloodstream, aggravating systemic inflammation. The molecular mechanism associated with this phenotype remains largely unknown. Cathelicidin represents one of the most important classes of antimicrobial peptides in mammals. In addition to bactericidal property, this peptide inhibits endotoxin-induced pyroptosis of leukocytes, suppresses the release of inflammatory mediators and protects endothelial cells from apoptosis [3–5]. In this study, we aimed to investigate the role of murine cathelicidin-related antimicrobial peptide (mCRAM), a rodent antimicrobial peptide analogous to human LL-37, in maintaining gut barrier function in sepsis.
着者Ho J, Liu XD, Kwong T, Zhang L, Chan H, Wong SH, Choi G, Gin T, Chan MTV, Wu WKK.
会议名称Sepsis 2016 Paris
会议开始日06.12.2016
会议完结日08.12.2016
会议地点Paris
会议国家法国
期刊名称CRITICAL CARE
会议论文集题名Critical care
出版年份2016
月份12
日期6
卷号20
期次Suppl. 3
出版社BioMed Central
页次189 - 191
国际标準期刊号1466-609X
语言美式英语
