Role of microRNAs in primary central nervous system lymphomas
Publication in refereed journal


香港中文大学研究人员 ( 现职)

胡嘉麒教授陈德威教授 (麻醉及深切治疗学系)

(麻醉及深切治疗学系)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1111/cpr.12243

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/1WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/2Scopus source URL

其它资讯

摘要Primary central nervous system lymphomas (PCNSL) are extranodal non-Hodgkin lymphomas arising exclusively inside the CNS, and account for about 3% of primary intracranial tumours. This tumour lacks systemic manifestations and prognosis of patients with PCNSL remains poor despite recent advancement of chemoradiotherapy. MicroRNAs are small non-coding RNAs that post-transcriptionally downregulate gene expression by binding to target mRNAs, inducing their degradation or translational repression. MicroRNAs play significant roles in almost all malignancy-related biological processes, including cell proliferation, differentiation, apoptosis and metabolism. Many deregulated miRNAs has been identified in PCNSL but their biological significance remains to be fully elucidated. In this review, we summarize current evidence regarding the pathogenic role of PCNSL-associated microRNAs and their potential applications for diagnosis and prognostication of this deadly disease.

着者Yu X., Li Z., Shen J., Chan M.T.V., Wu W.K.K.
期刊名称Cell Proliferation
出版年份http://aims.cuhk.edu.hk/converis/portal/Publication/20http://aims.cuhk.edu.hk/converis/portal/Publication/16
月份4
日期http://aims.cuhk.edu.hk/converis/portal/Publication/1
卷号49
期次http://aims.cuhk.edu.hk/converis/portal/Publication/2
出版社Blackwell Publishing Inc.
出版地United Kingdom
页次http://aims.cuhk.edu.hk/converis/portal/Publication/147 - http://aims.cuhk.edu.hk/converis/portal/Publication/153
国际标準期刊号0960-77http://aims.cuhk.edu.hk/converis/portal/Publication/2http://aims.cuhk.edu.hk/converis/portal/Publication/2
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1365-http://aims.cuhk.edu.hk/converis/portal/Publication/2http://aims.cuhk.edu.hk/converis/portal/Publication/184
语言英式英语