The Role of MicroRNAS in Ankylosing Spondylitis
Publication in refereed journal


香港中文大学研究人员 ( 现职)

胡嘉麒教授 (麻醉及深切治疗学系)

陈德威教授 (麻醉及深切治疗学系)

黄曦教授 (内科及药物治疗学系)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1097/MD.0000000000003325

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/1WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/2Scopus source URL

其它资讯

摘要Ankylosing spondylitis (AS) is a common and genetically heterozygous inflammatory rheumatic disease characterized by new bone formation, ankylosis and inflammation of hip, sacroiliac joints and spine. Until now, there is no method for early diagnosis of AS and the effective treatment available for AS patients remain largely undefined. We searched articles indexed in PubMed (MEDLINE) database using Medical Subject Heading (MeSH) or Title/words ("microRNA" and "ankylosing spondylitis") from inception up to November http://aims.cuhk.edu.hk/converis/portal/Publication/20http://aims.cuhk.edu.hk/converis/portal/Publication/15. Genetic polymorphisms of miRNAs and their targets might alter the risk of AS development whereas certain miRNAs exhibit correlation with inflammatory index. Let-7i and miR-http://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/24 were upregulated whereas miR-http://aims.cuhk.edu.hk/converis/portal/Publication/130a was downregulated in circulating immune cells of AS patients. These deregulated miRNAs could modulate key immune cell functions, such as cytokine response and T-cell survival. miRNA deregulation is key to AS pathogenesis. However, clinical utilization of miRNAs for management of AS patients requires further support from future translational studies.

着者Li Z., Wong S.H., Shen J., Chan M.T.V., Wu W.K.K.
期刊名称Medicine
出版年份http://aims.cuhk.edu.hk/converis/portal/Publication/20http://aims.cuhk.edu.hk/converis/portal/Publication/16
月份4
日期http://aims.cuhk.edu.hk/converis/portal/Publication/1
卷号95
期次http://aims.cuhk.edu.hk/converis/portal/Publication/14
出版社Lippincott Williams & Wilkins Ltd.
出版地United States
国际标準期刊号00http://aims.cuhk.edu.hk/converis/portal/Publication/25-7974
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1536-5964
语言英式英语