Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 陈德威教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1007/s13277-015-4514-8 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
其它资讯
摘要Wilms' tumor is the most common renal tumor in children in which diffusely anaplastic or unfavorable histology foreshadows poor prognosis. MicroRNAs are small, non-coding RNAs that negatively regulate gene expression at the posttranscriptional level. Accumulating evidence shows that microRNA dysregulation takes part in the pathogenesis of many renal diseases, such as chronic kidney diseases, polycystic kidney disease, renal fibrosis, and renal cancers. In Wilms' tumor, dysregulation of some key oncogenic or tumor-suppressing microRNAs, such as miR-17 similar to 92 cluster, miR-185, miR-2http://aims.cuhk.edu.hk/converis/portal/Publication/04, and miR-483, has been documented. In this review, we will summarize current evidence on the role of dysregulated microRNAs in the development of Wilms' tumor.
着者Yu X, Li Z, Chan MTV, Wu WKK
期刊名称Tumor Biology
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/016
月份2
日期1
卷号37
期次2
出版社SPRINGER
页次1445 - 145http://aims.cuhk.edu.hk/converis/portal/Publication/0
国际标準期刊号1http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0-4283
电子国际标準期刊号1423-http://aims.cuhk.edu.hk/converis/portal/Publication/038http://aims.cuhk.edu.hk/converis/portal/Publication/0
语言英式英语
关键词MicroRNAs; Nephroblastoma; Wilms' tumor
Web of Science 学科类别Oncology
