Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 陈德威教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/cpr.12269 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/8WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/8Scopus source URL
其它资讯
摘要Long non-coding RNAs (lncRNAs) are a group greater than 200 nucleotides in length. An increasing number of studies has shown that lncRNAs play important roles in diverse cellular processes, including proliferation, differentiation, apoptosis, invasion and chromatin remodelling. In this regard, deregulation of lncRNAs has been documented in human cancers. TUG1 is a recently identified oncogenic lncRNA whose aberrant upregulation has been detected in different types of cancer, including B-cell malignancies, oesophageal squamous cell carcinoma, bladder cancer, hepatocellular carcinoma and osteosarcoma. In these malignancies, knock-down of TUG1 has been shown to suppress cell proliferation, invasion and/or colony formation. Interestingly, TUG1 has been found to be downregulated in non-small cell lung carcinoma, indicative of its tissue-specific function in tumourigenesis. Pertinent to clinical practice, TUG1 may act as a prognostic biomarker for tumours. In this review, we summarize current knowledge concerning the role of TUG1 in tumour progression and discuss mechanisms associated with it.
着者Li Z., Shen J., Chan M.T.V., Wu W.K.K.
期刊名称Cell Proliferation
出版年份2016
月份http://aims.cuhk.edu.hk/converis/portal/Publication/8
日期1
卷号49
期次4
出版社Blackwell Publishing Inc.
出版地United Kingdom
页次471 - 475
国际标準期刊号0960-7722
电子国际标準期刊号1365-21http://aims.cuhk.edu.hk/converis/portal/Publication/84
语言英式英语
