Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 于君教授 (内科及药物治疗学系) |
| 刘晓东博士 (麻醉及深切治疗学系) |
| Professor Tony GIN (麻醉及深切治疗学系) |
| 黄曦教授 (内科及药物治疗学系) |
| 陈德威教授 (麻醉及深切治疗学系) |
| 王海天教授 (赛马会公共卫生及基层医疗学院) |
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 梁子杏教授 (麻醉及深切治疗学系) |
| 黄维达教授 (麻醉及深切治疗学系) |
| 何浩文博士 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1186/s13054-016-1555-3 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
其它资讯
摘要Background: Sepsis coincides with altered gene expression in different tissues. Accumulating evidence has suggested that microRNAs, long non-coding RNAs, and circular RNAs are important molecules involved in the crosstalk with various pathways pertinent to innate immunity, mitochondrial functions, and apoptosis.
Methods: We searched articles indexed in PubMed (MEDLINE), EMBASE and Europe PubMed Central databases using the Medical Subject Heading (MeSH) or Title/Abstract words ("microRNA", "long non-coding RNA", "circular RNA", "sepsis" and/or "septic shock") from inception to Sep 2http://aims.cuhk.edu.hk/converis/portal/Publication/016. Studies investigating the role of host-derived microRNA, long non-coding RNA, and circular RNA in the pathogenesis of and as biomarkers or therapeutics in sepsis were included. Data were extracted in terms of the role of non-coding RNAs in pathogenesis, and their applicability for use as biomarkers or therapeutics in sepsis. Two independent researchers assessed the quality of studies using a modified guideline from the Systematic Review Center for Laboratory animal Experimentation (SYRCLE), a tool based on the Cochrane Collaboration Risk of Bias tool.
Results: Observational studies revealed dysregulation of non-coding RNAs in septic patients. Experimental studies confirmed their crosstalk with JNK/NF-kappa B and other cellular pathways pertinent to innate immunity, mitochondrial function, and apoptosis. Of the included studies, the SYRCLE scores ranged from 3 to 7 (average score of 4.55). This suggests a moderate risk of bias. Of the 1http://aims.cuhk.edu.hk/converis/portal/Publication/0 articles investigating non-coding RNAs as biomarkers, none of them included a validation cohort. Selective reporting of sensitivity, specificity, and receiver operating curve was common.
Conclusions: Although non-coding RNAs appear to be good candidates as biomarkers and therapeutics for sepsis, their differential expression across tissues complicated the process. Further investigation on organ-specific delivery of these regulatory molecules may be useful.
着者Ho J, Chan H, Wong SH, Wang MHT, Yu J, Xiao ZG, Liu XD, Choi G, Leung CH, Wong WT, Li Z, Gin T, Chan MTV, Wu WKK.
期刊名称Critical Care
详细描述Article Number: 383
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/016
卷号2http://aims.cuhk.edu.hk/converis/portal/Publication/0
出版社BioMed Central
国际标準期刊号1364-8535
电子国际标準期刊号1364-8535
语言美式英语
关键词Sepsis, microRNA, lncRNA, circRNA, Biomarker, Inflammation, Shock
