Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 沈祖尧教授 (内科及药物治疗学系) |
| 于君教授 (内科及药物治疗学系) |
| 李中华先生 (内科及药物治疗学系) |
| 曹之宪教授 (生物医学学院) |
| 胡嘉麒教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.canlet.2010.04.025 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/84WOS source URL
其它资讯
摘要The pathogenesis of gastric cancer is complex and related to multiple factors. Dysregulation of intracellular signaling pathways represents a common pathogenic mechanism and may be amenable to drug targeting. Multiple well-established oncogenic pathways, such as those mediated by cell cycle regulators, nuclear factor-kappa B, cyclooxygenase-2 and epidermal growth factor receptor are implicated in gastric carcinogenesis. Emerging evidence also underscores the importance of signaling pathways involved in the developmental process, including transforming growth factor-beta/bone morphogenetic protein signaling, Wnt/beta-catenin signaling, Hedgehog signaling and Notch signaling. Understanding their biological significance will provide a rational basis for drug development. Their relative importance and cross-talk in gastric carcinogenesis, however, are still not completely understood and warrant further investigation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
着者Wu WKK, Cho CH, Lee CW, Fan DM, Wu KC, Yu J, Sung JJY
期刊名称Cancer Letters
出版年份2010
月份9
日期28
卷号295
期次2
出版社Elsevier
页次144 - 153
国际标準期刊号0304-3835
电子国际标準期刊号1872-7980
语言英式英语
关键词Cell signaling; Gastric cancer; Notch; Nuclear factor kappa B; Wnt
Web of Science 学科类别Oncology; ONCOLOGY
