Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 沈祖尧教授 (内科及药物治疗学系) |
| 于君教授 (内科及药物治疗学系) |
| 李中华先生 (内科及药物治疗学系) |
| 曹之宪教授 (生物医学学院) |
| 胡嘉麒教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.canlet.2009.12.002 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/62WOS source URL
其它资讯
摘要The ubiquitin-proteasome system is a major pathway for protein degradation. Targeting this pathway using proteasome inhibitors represents a novel approach for the treatment of cancer. Proteasome inhibitors lower cell proliferation and induce apoptosis in solid and hematologic malignancies through multiple mechanisms, including stabilization of cell cycle regulators and pro-apoptotic factors, stimulation of bone morphogenetic protein signaling, inhibition of protein translation, and sensitization to ligand-induced apoptosis. In this connection, proteasome inhibition activates macroautophagy, a compensatory protein degradation system, as well as other pro-survival signaling pathways. Inhibition of these auto-protective responses sensitizes cancer cells to the anti-proliferative effects of proteasome inhibitors. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
着者Wu WKK, Cho CH, Lee CW, Wu KC, Fan DM, Yu J, Sung JJY
期刊名称Cancer Letters
详细描述To ORKTS: doi: 10.1016/j.canlet2009.12.002
出版年份2010
月份7
日期1
卷号293
期次1
出版社Elsevier
页次15 - 22
国际标準期刊号0304-3835
电子国际标準期刊号1872-7980
语言英式英语
关键词Autophagy; Cancer; Proliferation; Proteasome inhibitor; Signaling
Web of Science 学科类别Oncology; ONCOLOGY
