Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 李民英教授 (麻醉及深切治疗学系) |
| Professor Gavin Matthew JOYNT (麻醉及深切治疗学系) |
| 田奇博士 (麻醉及深切治疗学系) |
| Professor Charles David GOMERSALL (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1159/000321488 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/23WOS source URL
其它资讯
摘要Background: Appropriate antibacterial therapy is important to maximize patient survival in sepsis. Acute renal failure complicates optimal antibiotic administration. Methods: MEDLINE search from 1986 to 2010 using the terms 'acute renal failure', 'pharmacokinetics', 'clearance', 'dosage', 'h(a)emofiltration', 'h(a)emodialysis', `h(a)emodiafiltration', `continuous renal replacement therapy', `antibiotics', `intensive care' and `critically ill'. Results: Maximal bacterial killing and minimization of side effects depend on achieving pharmacokinetic targets appropriate to the selected antibacterial agent. Volume of distribution and clearance may be altered by critical illness and/or acute kidney injury. Clearance is determined by nonrenal clearance, residual renal clearance and continuous renal replacement therapy dose. Sieving and saturation coefficients are membrane specific, but may be altered by changes in protein binding induced by critical illness. A significant proportion of studies failed to report the essential dataset required for adequate antibacterial dosage calculation. Conclusions: Individualized dosing based on first principles may be the most appropriate method of dosing, particularly when enhanced by therapeutic drug monitoring. Copyright (C) 2010 S. Karger AG, Basel
着者Choi G, Gomersall CD, Tian Q, Joynt GM, Li AMMY, Lipman J
期刊名称BLOOD PURIFICATION
出版年份2010
月份1
日期1
卷号30
期次3
出版社Karger Publishers
页次195 - 212
国际标準期刊号0253-5068
语言英式英语
关键词Acute renal failure; Antibacterial agents; Continuous renal replacement therapy; Pharmacodynamics; Pharmacokinetics
Web of Science 学科类别Hematology; HEMATOLOGY; Urology & Nephrology; UROLOGY & NEPHROLOGY
