Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 沈祖尧教授 (内科及药物治疗学系) |
| 于君教授 (内科及药物治疗学系) |
| 曹之宪教授 (生物医学学院) |
| 李中华先生 (内科及药物治疗学系) |
| 胡嘉麒教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1038/onc.2010.352 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/154WOS source URL
其它资讯
摘要Gastric carcinogenesis is a multistep process involving genetic and epigenetic alteration of protein-coding proto-oncogenes and tumor-suppressor genes. Recent discoveries have shed new light on the involvement of a class of noncoding RNA known as microRNA (miRNA) in gastric cancer. A substantial number of miRNAs show differential expression in gastric cancer tissues. Genes coding for these miRNAs have been characterized as novel proto-oncogenes and tumor-suppressor genes based on findings that these miRNAs control malignant phenotypes of gastric cancer cells. In this connection, miRNA dysregulation promotes cell-cycle progression, confers resistance to apoptosis, and enhances invasiveness and metastasis. Moreover, certain polymorphisms in miRNA genes are associated with increased risks for atrophic gastritis and gastric cancer, whereas circulating levels of miRNAs may serve as biomarkers for early diagnosis. Several miRNAs have also been shown to correlate with gastric cancer progression, and thus may be used as prognostic markers. Elucidating the biological aspects of miRNA dysregulation may help us better understand the pathogenesis of gastric cancer and promote the development of miRNA-directed therapeutics against this deadly disease. Oncogene (2010) 29, 5761-5771; doi: 10.1038/onc.2010.352; published online 30 August 2010
着者Wu WKK, Lee CW, Cho CH, Fan D, Wu K, Yu J, Sung JJY
期刊名称Oncogene
出版年份2010
月份10
日期1
卷号29
期次43
出版社Nature Publishing Group: Open Access Hybrid Model Option B
页次5761 - 5771
国际标準期刊号0950-9232
电子国际标準期刊号1476-5594
语言英式英语
关键词apoptosis; gastric cancer; metastasis; microRNA; proliferation; signaling pathway
Web of Science 学科类别Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Cell Biology; CELL BIOLOGY; Genetics & Heredity; GENETICS & HEREDITY; Oncology; ONCOLOGY
