Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 邓亮生教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1186/1471-2105-12-156 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/1WOS source URL
其它资讯
摘要Background: Recent association analyses in genome-wide association studies (GWAS) mainly focus on single-locus association tests (marginal tests) and two-locus interaction detections. These analysis methods have provided strong evidence of associations between genetics variances and complex diseases. However, there exists a type of association pattern, which often occurs within local regions in the genome and is unlikely to be detected by either marginal tests or interaction tests. This association pattern involves a group of correlated single-nucleotide polymorphisms (SNPs). The correlation among SNPs can lead to weak marginal effects and the interaction does not play a role in this association pattern. This phenomenon is due to the existence of unfaithfulness: the marginal effects of correlated SNPs do not express their significant joint effects faithfully due to the correlation cancelation.
着者Yang C, Wan X, Yang Q, Xue H, Tang NLS, Yu WC
期刊名称BMC Bioinformatics
出版年份20http://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/1
月份5
日期http://aims.cuhk.edu.hk/converis/portal/Publication/14
卷号http://aims.cuhk.edu.hk/converis/portal/Publication/12
出版社BIOMED CENTRAL LTD
国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/147http://aims.cuhk.edu.hk/converis/portal/Publication/1-2http://aims.cuhk.edu.hk/converis/portal/Publication/105
语言英式英语
Web of Science 学科类别Biochemical Research Methods; BIOCHEMICAL RESEARCH METHODS; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Mathematical & Computational Biology; MATHEMATICAL & COMPUTATIONAL BIOLOGY
