Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 锺国衡教授 (妇产科学系) |
| 王益夫教授 (妇产科学系) |
| 詹兆?教授 (妇产科学系) |
| 李?珊小姐 (化学病理学系) |
| 陈洁盈女士 (妇产科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1159/000323883 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/21WOS source URL
其它资讯
摘要Background: The CHD5 gene located on 1p36 encodes a protein - chromodomain helicase DNA-binding protein 5. CHD5 has been shown to be a tumor suppressor gene candidate. This study investigated the involvement of CHD5 in ovarian cancer and its clinicopathological significance. Methods: CHD5 expression in ovarian cancer and its counterpart were determined by quantitative RT-PCR. The correlation of CHD5 expression to clinicopathological features of the tumor was analyzed. Results: CHD5 expression was downregulated by at least twofold in 32 of 72 (41%) invasive epithelial ovarian carcinomas when compared to 12 controls in Hong Kong Chinese women. CHD5 downregulation was correlated to clinical status (p < 0.05), but not to patient age, tumor type and grade, recurrence and clinical stage (p > 0.05). Survival analysis showed that patients with CHD5 downregulation in their tumors were associated with shorter disease-free and total survival times compared to those without CHD5 downregulation (p < 0.05). Cox proportional-hazards regression analysis indicated that downregulation of CHD5 is an independent adverse prognostic factor in ovarian cancer. Conclusion: This study shows that CHD5 is downregulated in a certain number of ovarian cancers and appears to be an adverse predictor candidate of ovarian cancer disease-free and total survival. Copyright (C) 2011 S. Karger AG, Basel
着者Wong RRY, Chan LKY, Tsang TPT, Lee CWS, Cheung TH, Yim SF, Siu NSS, Lee SNC, Yu MY, Chim SSC, Wong YF, Chung TKH
期刊名称Gynecologic and Obstetric Investigation
出版年份2011
月份1
日期1
卷号72
期次3
出版社Karger Publishers
页次203 - 207
国际标準期刊号0378-7346
电子国际标準期刊号1423-002X
语言英式英语
关键词CHD5; Downregulation; Ovarian cancer
Web of Science 学科类别Obstetrics & Gynecology; OBSTETRICS & GYNECOLOGY
