Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 黄永坚教授 (儿科学系) |
| 林伟基教授 (化学病理学系) |
| 翁颂铭先生 (儿科学系) |
| 梁廷勋教授 (儿科学系) |
全文
| 数位物件识别号 (DOI) ○○@http://aims.cuhk.edu.hk/converis/portal/Publication/6$@○○ |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/6WOS source URL
其它资讯
摘要Indoor aeroallergen exposures increased asthma symptoms in Caucasians, but their determinants and relationship to asthma and allergy in Asians are unclear This study investigated exposures to cat, cockroach, and Blomia tropicalis allergens in 115 Hong Kong families with asthmatic children. Patients underwent exhaled nitric oxide and spirometric measurements. Home visits were made within 2 weeks during which parents completed a standardized questionnaire. Fel d 1, Bla g 2, and Blo t 5 in dust samples collected from patients' mattresses, bedroom floors, and living room floors were measured by immunoassays. These aeroallergens were only detectable in some homes (38-55% for Fel d 1; 9-21% for Bla g 2, and 7-14% for Blot 5). The presence of cat and/or dog was a strong determinant for Fel d 1 in all indoor sites. The timing and frequency of bedding change was associated with Bla g 2 levels, whereas the timing of bedroom floor cleaning was a consistent factor for Blot 5 levels. Asthmatic children in families with high allergen exposure were more likely to have >= 4 wheezing attacks in preceding 12 months and exercise-induced wheezing than those with normal allergen exposure (P = 0.051 and 0.030, respectively). Mattress levels of all three allergens were also associated with severity of several allergy symptoms (P = 0.025-0.005). None of these aeroallergens correlated with exhaled nitric oxide and spirometric parameters. This study identifies determinants for cat, cockroach, and B. tropicalis levels in Hong Kong families with asthmatic children. These exposures are associated with severity of allergy symptoms. Pediatr Pulmonol. 2011; 4http://aims.cuhk.edu.hk/converis/portal/Publication/6:http://aims.cuhk.edu.hk/converis/portal/Publication/632-http://aims.cuhk.edu.hk/converis/portal/Publication/639. (C) 2011 Wiley-Liss, Inc.
着者Leung TF, Wong YS, Chan IHS, Yung E, Sy HY, Lam CWK, Wong GWK
期刊名称PEDIATRIC PULMONOLOGY
详细描述To ORKTS: RGC ERG
number CUHK 4512/0http://aims.cuhk.edu.hk/converis/portal/Publication/6M
出版年份2011
月份7
日期1
卷号4http://aims.cuhk.edu.hk/converis/portal/Publication/6
期次7
出版社WILEY-BLACKWELL
页次http://aims.cuhk.edu.hk/converis/portal/Publication/632 - http://aims.cuhk.edu.hk/converis/portal/Publication/639
国际标準期刊号8755-http://aims.cuhk.edu.hk/converis/portal/Publication/68http://aims.cuhk.edu.hk/converis/portal/Publication/63
电子国际标準期刊号1099-049http://aims.cuhk.edu.hk/converis/portal/Publication/6
语言英式英语
关键词aeroallergen; asthma; exhaled nitric oxide; house dust; lung function
Web of Science 学科类别Pediatrics; PEDIATRICS; Respiratory System; RESPIRATORY SYSTEM
