Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 崔耀隆教授 (化学病理学系) |
| 李嘉豪教授 (生物医学学院) |
| Dr ROWLANDS Dewi Kenneth |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.bbrc.2009.12.111 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/6WOS source URL
其它资讯
摘要BRE, also known as TNFRSF1A modulator and BRCC45, is an evolutionarily highly conserved protein. It is a death receptor-associated protein in cytoplasm and a component of BRCA1/2-containing DNA repair complex in nucleus. BRE was found to have anti-apoptotic activity. Over-expression of BRE by transfection promoted survival of cell lines against apoptotic induction; whereas depletion of the protein by siRNA resulted in the opposite. In vivo anti-apoptotic activity of BRE was demonstrated by significant attenuation of Fas-induced acute fulminant hepatitis in transgenic mice expressing the human protein specifically in the liver. BRE was also implicated in tumor promotion by the accelerated tumor growth of Lewis Lung carcinoma transfected with human BRE; and by high expression of BRE specifically in the tumoral regions of human hepatocellular carcinoma (HCC). The present study was to test directly if transgenic expression of BRE in livers Could promote HCC development in neonatal diethylnitrosamine model. By 8 months after tumor induction, the maximal sizes of tumor nodules of transgenic mice were significantly larger than those of the non-transgenic controls, although the numbers of tumor nodules between the two groups did not significantly differ. Importantly, as in human HCC, the mouse endogenous BRE level was up-regulated in mouse HCC nodules. These results show that BRE over-expression can indeed promote growth, though not initiation, of liver tumors. Furthermore, the common occurrence of BRE over-expression in human and mouse HCC suggests that up-regulation of BRE is functionally important in liver tumor development. (c) 2009 Elsevier Inc. All rights reserved.
着者Chui YL, Ching AKK, Chen SY, Yip FP, Rowlands DK, James AE, Lee KKH, Chan JYH
期刊名称Biochemical and Biophysical Research Communications
出版年份2010
月份1
日期15
卷号391
期次3
出版社Elsevier
页次1522 - 1525
国际标準期刊号000http://aims.cuhk.edu.hk/converis/portal/Publication/6-291X
电子国际标準期刊号1090-2104
语言英式英语
关键词Apoptosis; BRE; Diethylnitrosamine; Hepatocellular carcinoma
Web of Science 学科类别Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS
