Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 吕智伟教授 (病理解剖及细胞学系) |
| 陈永鸿教授 (病理解剖及细胞学系) |
| 王思朗博士 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1007/s00795-010-0495-2 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/13WOS source URL
其它资讯
摘要This study evaluated the expression of biological markers of breast cancers with brain metastases. Eighteen paired tumors were assessed, with 42 non-brain-metastasizing breast cancers that were stained with ER, PR, HER2, CK5/6, p63, and Ki67, and were also classified into intrinsic subtypes. The expression patterns between the breast tumors with brain metastases were compared to the brain metastases and the controls. Breast cancers with brain metastases were of higher grade and showed higher incidence of lymph node metastases at initial diagnosis and higher EGFR, p63, and Ki67 expression. In the group of breast cancers with brain metastases, the brain metastases showed higher HER2, CK5/6, and Ki67 expression compared to the breast primaries. There was also a higher incidence of basal subtype and a lower incidence of luminal subtype. When tumors metastasized, changes in hormonal receptor (22%) and HER2 (6%) status were observed. We concluded that breast cancers with higher grade, lymph node involvement at diagnosis, high EGFR, p63, and Ki67 expression, and of basal subtype were at higher risk for brain metastases, and that both hormonal receptors and HER2 status may change in brain metastases.
着者Shao MM, Liu J, Vong JS, Niu Y, Germin B, Tang P, Chan AWH, Lui PCW, Law BKB, Tan PH, Tse GM
期刊名称MEDICAL MOLECULAR MORPHOLOGY
出版年份2011
月份3
日期1
卷号44
期次1
出版社Springer Verlag (Germany)
页次15 - 20
国际标準期刊号1860-1480
语言英式英语
关键词Basal; Breast; Carcinoma; HER2; Metastasis
Web of Science 学科类别Biology; Life Sciences & Biomedicine - Other Topics; Microscopy; Pathology; PATHOLOGY
