Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 冯国培教授 (生物医学学院) |
| 黄志超教授 (妇产科学系) |
| 霍泰辉教授 (儿科学系) |
| 黄振国教授 (化学病理学系) |
| 何宗信教授 (化学病理学系) |
| 陈月华博士 (那打素护理学院) |
| 朱静欣小姐 (妇产科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.toxlet.2010.10.004 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/18WOS source URL
其它资讯
摘要Pharmacokinetics of melamine has not been studied in pregnancies despite of the many reports on the effect on renal damage in adult and neonates. In this study, Sprague-Dawley rats have been used as a model to study the single-dose effect of melamine administration in late pregnancy and in neonates within 24h. Melamine concentrations in maternal serum, breast milk, whole foetus, amniotic fluid, neonatal serum and neonatal kidney was measured by liquid chromatography coupled with mass spectrometry. Melamine was detected in all the samples, including foetal rats and amniotic fluid in utero. Melamine was able to pass through placenta and reach the foetus, and to accumulate in lactating mammary gland and neonatal kidney. Moreover, melamine was eliminated through the placenta of the foetus and the kidneys of the neonates, and later excreted into the amniotic fluid. The study characterised for the first time the distribution of melamine in foetuses and neonates, providing reference for toxicological study of melamine during pregnancy. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
着者Chu CY, Chu KO, Chan JYW, Liu XZ, Ho CS, Wong CK, Lau CM, Ting TL, Fok TF, Fung KP, Wang CC
期刊名称Toxicology Letters
出版年份2010
月份12
日期15
卷号199
期次3
出版社Elsevier
页次398 - 402
国际标準期刊号0378-4274
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1879-3169
语言英式英语
关键词Fetus; Melamine; Neonate; Pharmacokinetics; Pregnant
Web of Science 学科类别Toxicology; TOXICOLOGY
