Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 卢煜明教授 (化学病理学系) |
| 赵慧君教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.4161/chim.1.1.12439 |
引用次数
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/12Scopus source URL
其它资讯
摘要The presence of fetal DNA in the plasma of pregnant women has opened up new possibilities for noninvasive prenatal diagnosis. Over the past decades, different types of fetal markers have been developed, initially based on discriminative genetic markers such as male-specific signals or paternallyinherited polymorphisms, and gradually evolved to the detection of fetal-specific transcripts or epigenetic signatures. This development has extended the coverage of the application of cell-free fetal DNA to essentially all pregnancies, regardless of the gender of the fetus or its polymorphic status. In this review, we present an overview of the development of noninvasive prenatal diagnosis through epigenetics. We introduce the basis of how fetal DNA could be detected from a large background of maternal DNA in maternal plasma based on fetal-specific DNA methylation patterns. We evaluate the methodologies involved and discuss the factors that affect the robustness of the detection. We review the progress in adopting fetal epigenetic markers for noninvasive prenatal assessment of fetal chromosomal aneuploidies and pregnancyassociated disorders. We conclude with comments on the future directions regarding the search for new fetal epigenetic markers and the clinical implementation of epigenetic approaches for noninvasive prenatal diagnosis. ? 2010 Landes Bioscience.
着者Tsui D.W.Y., Chiu R.W.K., Dennis Lo Y.M.
期刊名称Chimerism
出版年份2010
月份http://aims.cuhk.edu.hk/converis/portal/Publication/12
日期1
卷号1
期次1
出版社Landes Bioscience
出版地United States
页次30 - 35
国际标準期刊号1938-1956
语言英式英语
关键词DNA methylation, Epigenetics, Fetal chromosomal aneuploidies, Fetal DNA, Noninvasive prenatal diagnosis, Plasma DNA
