Refereed conference paper presented and published in conference proceedings
香港中文大学研究人员 ( 现职)
| 邓亮生教授 (化学病理学系) |
| 包立怡教授 (药剂学院) |
| 陈重娥教授 (内科及药物治疗学系) |
| 汤宁信教授 |
| 马青云教授 (内科及药物治疗学系) |
| 梁廷勋教授 (儿科学系) |
| 邱宇青博士 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1109/BIBMW.2010.5703914 |
引用次数
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/0Scopus source URL
其它资讯
摘要With development of high-throughput genotyping technologies, many genome-wide association studies on common diseases have been launched in Hong Kong. However, the population structure of Hong Kong population remains enigmatic. In GWAS, population stratification might cause problems of spurious associations. In this study, we report one of the first surveys of autosomal DNA diversity within the Hong Kong Chinese population. Principal component analysis results show that Hong Kong Chinese population is genetically closer to southern than northern Chinese populations. This pattern is consistent with geographic distribution and linguistic affiliation of Chinese population. There is also admixture of northern and southern Chinese genetic ancestries as indicated by stratification in the Hong Kong Chinese population, which is in accordance to known historical immigrations. At the SNP level, ancestry informative SNPs among Chinese populations, principal-component-correlated SNPs and SNPs showing significance in simulated case-control studies were identified. These variations characterize Hong Kong Chinese population which might have been affected by immigration, gene flow or natural selection. Thus, disease association results located on or near these loci are often not replicable in the second phase of GWAS, which may call for stratification adjustment using methods which have been evaluated and being implemented in practice. Our findings provide insights for designing GWAS, filtering out confounding results and correcting stratification in Hong Kong Chinese population. ?2http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0 IEEE.
着者Qiu Y.-Q., Leung T.-F., Ma R.C.W., Tomlinson B., Chan J.C.N., Tang N.L.S., Baum L.
会议名称2http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0
会议开始日18.12.2http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0
会议完结日21.12.2http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0
会议地点HongKong
会议国家香港
详细描述organized by IEEE,
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0
月份12
日期1
页次8http://aims.cuhk.edu.hk/converis/portal/Publication/02 - 8http://aims.cuhk.edu.hk/converis/portal/Publication/03
国际标準书号9781424483http://aims.cuhk.edu.hk/converis/portal/Publication/044
语言英式英语
关键词GWAS, Hong Kong Chinese, Population stratification
