Publication in refereed journal
香港中文大学研究人员 ( 现职)
| Professor Edmund Anthony Severn NELSON (儿科学系) |
| 林伟基教授 (化学病理学系) |
| 苏鸿钧博士 (儿科学系) |
| 李民瞻教授 (儿科学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
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摘要Aims: To evaluate the correlation between hypothalamic-pituitary-adrenal (HPA) axis activity with degree of obesity, severity of obstructive sleep apnoea (OSA) and laboratory parameters in a group of obese Chinese children. Methods: Consecutive children with primary obesity were recruited from the Obesity & Lipid Disorder Clinic of a university teaching hospital. Degree of obesity was assessed by anthropometric measurements. Those with habitual snoring (snoring for > 3 nights per week) underwent overnight sleep study. Laboratory measurements included fasting plasma glucose, lipid profile, and serum insulin. Twenty-four-hour urinary free cortisol (UFC) excretion was used as a surrogate marker of HPA axis activity. Results: One hundred ninety-six children were studied and their median age and body mass index (BMI) were 12.1 (IQR 9.9-13.9) years and 29.5 (26.2-33.4), respectively. Boys were more obese and had significantly higher UFC than girls (16http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0 vs 132.4 nmol/day, p=http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/016). Spearman's rank correlation revealed significant positive association between UFC and anthropometric markers of obesity, namely, BMI, waist circumference, and skinfold thickness. There was also negative association between UFC and plasma high-density lipoprotein concentrations. In boys, a positive correlation was demonstrated between UFC and serum insulin concentrations. However, unlike previous publications, only age and male gender were significant independent factors associated with UFC excretion in multivariate analysis. Eighteen children had OSA but no correlation was found between UFC and severity of OSA. Conclusion: Twenty-four-hour urinary free cortisol is not able to delineate any HPA axis dys-regulation in this cohort, further studies will be required to investigate the relationship between obesity and cortisol pathway in children.
着者Ho ACH, Li AM, Chan MHM, Wong EMC, Chan IHS, Chan DFY, So HK, Fu CC, Chan SSK, Lam CWK, Nelson EAS
期刊名称HONG KONG JOURNAL OF PAEDIATRICS
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/08
月份4
日期1
卷号13
期次2
出版社MEDCOM LTD
页次82 - 89
国际标準期刊号1http://aims.cuhk.edu.hk/converis/portal/Publication/013-9923
电子国际标準期刊号23http://aims.cuhk.edu.hk/converis/portal/Publication/09-5393
语言英式英语
关键词hypothalamic-pituitary-adrenal axis; insulin; obesity; obstructive sleep apnoea; urinary free cortisol excretion
Web of Science 学科类别Pediatrics; PEDIATRICS
