Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 荣润国教授 (精神科学系) |
| 林伟基教授 (化学病理学系) |
| 苏鸿钧博士 (儿科学系) |
| 林鸿生教授 (儿科学系) |
| 李民瞻教授 (儿科学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/12WOS source URL
其它资讯
摘要Objective: To evaluate serum cytokine concentrations in children with and without obstructive sleep apnoea (OSA) and to investigate the effects of OSA treatment on cytokines. Materials and Methods: Consecutive children with habitual snoring and symptoms suggestive of OSA were recruited. They completed asleep apnoea symptom questionnaire, underwent physical examination and overnight polysomnography (PSG). OSA was diagnosed if obstructive apnoea index (OAI) >1. A blood sample was collected for analysis of IL-6, IL-8, and TNF-alpha after PSG. Results: One hundred forty-two children (97 males) with a median (IQR) age of 11.1 years (9.0-http://aims.cuhk.edu.hk/converis/portal/Publication/12.8) were recruited. The commonest presenting symptoms were nocturnal mouth breathing, prone sleeping position and poor attention at school. Forty-seven children were found to have OSA and they had higher serum IL-6 [0.1 (0.1-0.4) vs 0.1 (0.1-0.1) pg/mL, P = 0.001] and IL-8 [1.7 (1.0-2.3) vs 1.3 (0.9-1.7) pg/mL, P= 0.029] concentrations compared to their non-OSA counterparts. Multiple regression analysis indicated that OAI was significantly associated with both IL-6 (r = 0.351, P <0.001) and IL-8 (r = 0.266, P = 0.002). Sixteen children underwent treatment and there was significant reduction in mean (SD) serum IL-8 after intervention [pre vs post levels of 1.9 (1.0) vs 1.1 (0.6) pg/mL, P = 0.001] independent of weight loss. Conclusion: Children with OSA had elevated levels of pro-inflammatory cytokines that normalised following treatment suggesting that the inflammatory response is potentially reversible. Early detection and intervention may be beneficial.
着者Li AM, Lam HS, Chan MHM, So HK, Ng SK, Chan IHS, Lam CWK, Wing YK
期刊名称ANNALS ACADEMY OF MEDICINE SINGAPORE
出版年份2008
月份8
日期1
卷号37
期次8
出版社ACAD MEDICINE SINGAPORE
页次649 - 654
国际标準期刊号0304-4602
语言英式英语
关键词interleukin 6; interleukin 8; polysomnography; tumour necrosis factor
Web of Science 学科类别General & Internal Medicine; Medicine, General & Internal; MEDICINE, GENERAL & INTERNAL
