Curcumin effects on blood lipid profile in a 6-month human study
Publication in refereed journal


香港中文大学研究人员 ( 现职)

林伟基教授 (化学病理学系)

郭志锐教授 (内科及药物治疗学系)

郑景辉博士 (中医中药研究所)

莫丽芬女士 (内科及药物治疗学系)

黄沛霖教授 (内科及药物治疗学系)

徐仲?教授 (赛马会公共卫生及基层医疗学院)

高威廉教授 (赛马会公共卫生及基层医疗学院)

赵凤琴教授 (精神科学系)

胡令芳教授 (内科及药物治疗学系)

周柽森教授 (药剂学院)

林翠华教授 (精神科学系)

莫仲棠教授 (内科及药物治疗学系)

包立怡教授 (药剂学院)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.phrs.2007.09.013

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/50WOS source URL

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摘要Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects (n=36) consumed 4g/d curcumin, 1 g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490 nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol. (c) 2007 Elsevier Ltd. All rights reserved.

着者Baum L, Cheung SKK, Mok VCT, Lam LCW, Leung VPY, Hui E, Ng CCY, Chow M, Ho PC, Lam S, Woo J, Chiu HFK, Goggins W, Zee B, Wong A, Mok H, Cheng WKF, Fong C, Lee JSW, Chan MH, Szeto SSL, Lui VWC, Tsoh J, Kwok TCY, Chan IHS, Lam CWK
期刊名称PHARMACOLOGICAL RESEARCH
出版年份2007
月份12
日期1
卷号56
期次6
出版社ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
页次http://aims.cuhk.edu.hk/converis/portal/Publication/509 - 514
国际标準期刊号1043-6618
语言英式英语

关键词cholesterol; curcumin; high-density lipoprotein; low-density lipoprotein; triglycerides
Web of Science 学科类别Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY