Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 潘力行教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) ○○@http://aims.cuhk.edu.hk/converis/portal/Publication/2$@○○ |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/2WOS source URL
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摘要High attitude inhabitants (HAI) are generally smaller than low attitude inhabitants (LAI). This anthropological observation has recently been confirmed in the Tibetan refugees who have settled in India since 1950s. Those settled at lower attitudes (970 m) are tatter and muscular than compatriots settled at higher attitudes (3500 m). While lower socioeconomic status is implicated in growth retardation at higher attitudes, the smaller stature in adults in well-off communities says otherwise. Hypobaric hypoxia (HH) is the main challenge at high attitudes, which the long established HAI have overcome via biological adaptations, including larger chests, raised blood hemoglobin, and producing more nitric oxide (NO), which deliver similar levels of oxygen to tissues, as LAI. The Tibetans produce 10-fold more NO than LAI. NO is a potent inhibitor of steroidogenesis. Therefore I hypothesize that the short stature and tower musculature in HAI results from steroid deficiency precipitated by NO, which HAI produce to cope with HH. (C) http://aims.cuhk.edu.hk/converis/portal/Publication/2008 Elsevier Ltd. All rights reserved.
着者Panesar NS
期刊名称MEDICAL HYPOTHESES
出版年份http://aims.cuhk.edu.hk/converis/portal/Publication/2008
月份9
日期1
卷号71
期次3
出版社CHURCHILL LIVINGSTONE
页次453 - 456
国际标準期刊号0306-9877
语言英式英语
Web of Science 学科类别Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Research & Experimental Medicine
