Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 卢煜明教授 (化学病理学系) |
| 罗国炜教授 (病理解剖及细胞学系) |
| 刘子建教授 (妇产科学系) |
| 梁子昂教授 (妇产科学系) |
| 汤羽君博士 (化学病理学系) |
| 袁伟芳女士 (病理解剖及细胞学系) |
| 沈秀媛教授 (生物医学学院) |
| 唐红文博士 (病理解剖及细胞学系) |
| 杜家辉教授 (病理解剖及细胞学系) |
| 李?珊小姐 (化学病理学系) |
| 黄思铨教授 (肿瘤学系) |
| 詹兆?教授 (妇产科学系) |
| 赵慧君教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.2353/ajpath.2007.060641 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/85WOS source URL
其它资讯
摘要The pseudomalignant nature of the placenta prompted us to search for tumor suppressor gene hypermethylation, a phenomenon widely reported in cancer, in the human placenta. Nine tumor suppressor genes were studied. Hypermethylation of the Ras association domain family 1 A (RASSF1A) gene was found in human placentas from all three trimesters of pregnancy but was absent in other fetal tissues. Hypermethylation of Rassf1 was similarly observed in placentas from the rhesus monkey but not the mouse. An. inverse relationship between RASSF1A promoter methylation and gene expression was demonstrated by bisulfite sequencing of microdissected placental cells and immunohistochemical staining of placental tissue sections using an anti-RASSF1A antibody. Treatment of choriocarcinoma cell lines, JAR and JEG3, by 5-aza-2'-deoxycytidine and trichostatin A led to reduction in RASSF1A methylation but increased expression. These observations extend the analogy between the primate placenta and malignant tumors to the epigenetic level.
着者Chiu RWK, Chim SSC, Wong IHN, Wong CSC, Lee WS, To KF, Tong JHM, Yuen RKC, Shum ASW, Chan JKC, Chan LYS, Yuen JWF, Tong YK, Weier JF, Ferlatte C, Leung TN, Lau TK, Lo KW, Lo YMD
期刊名称AMERICAN JOURNAL OF PATHOLOGY
出版年份2007
月份3
日期1
卷号170
期次3
出版社AMER SOC INVESTIGATIVE PATHOLOGY, INC
页次941 - 950
国际标準期刊号0002-9440
语言英式英语
Web of Science 学科类别Pathology; PATHOLOGY
