Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 胡令芳教授 (内科及药物治疗学系) |
| 梁秉中教授 (中医中药研究所) |
| 梁志信先生 (香港中文大学赛马会骨质疏鬆预防及治疗中心) |
| 邓亮生教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.mad.2008.08.003 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/56WOS source URL
其它资讯
摘要Associations between telomere length and various chronic diseases associated with ageing have led to the suggestion that telomere length may be an ageing biomarker. At the clinical level, the suggestion of using measurements of frailty as a measure of biological ageing has also been suggested. This study examines the hypothesis that telomere shortening may form the biological basis for frailty, using data obtained from a health survey of 2000 men and women aged 65 years and over, living in the community, and followed up for 4 years to determine survival. Frailty was measured using the frailty index, a summation of deficits covering physical, psychological, and functional domains. Telomere length was measured in 976 men and 1030 women, using real-time quantitative polymerase chain reaction. Women were more frail than men but had longer telomere length. In men only, there was a negative association between telomere length and age and a positive association between frailty index and mortality after adjusting for age. There was no correlation between telomere length and frailty index in either sex. While telomere length may be a biomarker of cellular senescence, this relationship may not be extrapolated to the functional level represented by the frailty phenotype. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
着者Woo J, Tang NLS, Suen E, Leung JCS, Leung PC
期刊名称MECHANISMS OF AGEING AND DEVELOPMENT
出版年份2008
月份11
日期1
卷号129
期次11
出版社Elsevier
页次642 - 648
国际标準期刊号0047-6374
语言英式英语
关键词Ageing; Frailty; Telomere length
Web of Science 学科类别Cell Biology; CELL BIOLOGY; Geriatrics & Gerontology; GERIATRICS & GERONTOLOGY
