聂舟
教授，博士生导师
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研究方向：功能蛋白质和核酸的生物传感新方法研究

聂舟，男，博士，湖南大学化学化工学院教授，博士生导师。2002年本科毕业于南开大学生物化学与分子生物学系，获理学学士学位；2007年于中国科学院化学研究所获物理化学博士学位；2012年于美国Purdue大学从事博士后（公派）研究工作。主要研究方向为功能蛋白质和核酸的生物传感新方法研究。自2009年以来作为通讯作者在AngewandteChemie International Edition、Chemical Science、Trends in Analytical Chemistry、Analytical Chemistry、Small、Chemical Communications、Chemistry-A European Journal、Nanoscale、Biosensors and Bioelectronics等SCI收录源刊物上发表SCI论文40余篇（影响因子> 5，32篇），近五年论文他引1000余次，其中单篇他引90余次。获国家发明专利授权1项，受邀为Springer出版社撰写英文学术专著2章。5年内主持国家自然科学基金4项，省部级项目4项，参与973子课题2项。2015年入选中组部****青年拔尖人才；2012年获得首届国家自然科学基金青年基金项目；是国家自然科学基金委创新研究群体基金项目的主要成员之一；2010年入选教育部新世纪人才支持计划，2013年入选首届湖湘青年科技创新创业平台培养对象；2014年获得湖南省杰出青年基金支持。2015年7月应邀出任英国皇家化学会所属学术期刊《RSC Advances》副主编。

Selected Publications:

1.K.Y. He, Y. Li, B.B. Xiang, P. Zhao, Y.F. Hu, Y. Huang, W. Li, Z.Nie*, S.Z. Yao. A universal platform for building molecular logic circuits based on a reconfigurable three-dimensional DNA nanostructure. Chem. Sci, 2015,6, 3556-3564.

2. Y.T. Han, P. Li, Y.T. Xu, H. Li, Z.L. Song, Z. Nie*, Z. Chen*, S.Z. Yao. Fluorescent nanosensor for probing histone acetyltransferase activity based on acetylation protection and magnetic graphitic nanocapsules, Small, 2015, 11, 877-885.
3.P. Zhao, K.Y. He, Y.T. Han, Z. Zhang, M.Z. Yu, H.H. Wang, Y. Huang, Z. Nie*, S.Z. Yao.Near-Infrared Dual-Emission Quantum Dots–Gold NanoclustersNanohybrid via Co-Template Synthesis for Ratiometric Fluorescent Detection and Bioimaging of Ascorbic Acid In Vitro and In Vivo.Anal. Chem. 2015, DOI: 10.1021/acs.analchem.5b02614.

4. Y.T. Han, H. Li, Y.F.Hu, P. Li, H.X. Wang,Z. Nie*, S.Z. Yao.Time-Resolved Luminescence Biosensor for Continuous Activity Detection of Protein Acetylation-Related Enzymes Based on DNA-Sensitized Terbium(III) Probes. Anal. Chem. 2015, 87, 9179–9185.

5. C. Yin, M. Wang, C.Y. Lei, Z. Wang, P. Li, Y. Li, W. Li, Y. Huang,* Z. Nie*, S.Z. Yao.Phosphorylation-Mediated Assembly of a Semisynthetic Fluorescent Protein for Label-Free Detection of Protein Kinase Activity. Anal. Chem. 2015, 87, 6311–6318.

6. S.Y. Chen, Y. Li, Y.F. Hu, Y.T. Han, Y. Huang,Z. Nie*, S.Z. Yao. Nucleic Acid-mimicking CoordinationPolymerforLabel-free Fluorescent Activity Assay of Histone Acetyltransferases, ChemCommun. 2015, 51, 4469-4472.

7. S. Tang, Z. Nie*, W. Li*, D.Q. Li, Y. Huang,S.Z. Yao.A poly(ADP-ribose) polymerase-1 activity assay based on the FRET between a cationic conjugated polymer and supercharged green fluorescent protein.Chem. Commun., 2015,51, 14389-14392.

8. Z. Wang,Y. Li, L.J. Li,D.Q. Li, Y. Huang*,Z.Nie*,S.Z. Yao.DNA-mediated supercharged fluorescent protein/graphene oxide interaction for label-free fluorescence assay of base excision repair enzyme activity. Chem. Commun., 2015,51, 13373-13376.

9.C.Y. Lei, Y. Huang, Z. Nie*, J. Hu, L.J. Li, G.Y. Lu, Y.T. Han, S.Z. Yao. Supercharged fluorescent protein as a versatile probe for homogenous DNA detection and methylation analysis. Angew. Chem. Int. Ed., 2014, 53, 8358–8362. (Hot Paper)
10.Z. Nie*, P.F. Wang, C. Tian, C.D. Mao*. Synchronization of Two Assembly Processes to Build Responsive DNA Nanostructures. Angew. Chem. Int. Ed., 2014, 53, 8402–8405.
11.X. Liu, Y. Li, X.H. Xu, P. Li, Z. Nie*, Y. Huang, S.Z. Yao*. Nanomaterial-based tools for protein kinase bioanalysis. Trends Anal. Chem., 2014, 58, 40-53.
12.Z.L. Liu, W. Li, Z. Nie*, F.F. Peng, Y. Huang, S.Z. Yao. Randomly arrayed G-quadruplexes for label-free and real-time assay of enzyme activity. Chem. Commun., 2014, 50, 6875-6878.
13.J. Zhou, X.H. Xu, W. Liu, X. Liu, Z. Nie*, M. Qing, L.H. Nie, S.Z. Yao. Graphene Oxide?Peptide Nanocomplex as a Versatile Fluorescence Probe of Protein Kinase Activity Based on Phosphorylation Protection against Carboxypeptidase Digestion. Anal. Chem., 2013, 85, 5746–5754.
14.P. Zhao, L.F. Zhou, Z. Nie*, X.H. Xu, W. Li, Y. Huang, K.Y. He, S.Z. Yao. Versatile Electrochemiluminescent Biosensor for Protein?Nucleic Acid Interaction Based on the Unique Quenching Effect of Deoxyguanosine-5’-phosphate on Electrochemiluminescence of CdTe/ZnS Quantum Dots. Anal. Chem., 2013, 85, 6279–6286.
15.X. Liu, S.Y. Zhang, P.L. Tan, J. Zhou, Y. Huang, Z. Nie*, S.Z. Yao. A plasmonic blood glucose monitor based on enzymatic etching of gold nanorods. Chem. Commun., 2013, 49, 1856-1858.
16.Z. Nie, X. Li, Y.M. Li, C. Tian, P.F. Wang, C.D. Mao*, Self-assembly of DNA nanoprisms with only two component strands. Chem. Commun., 2013, 49, 2807-2809.
17.F.F. Li, C.Y. Lei, Q.P. Shen, L.J. Li, M. Wang, M.L. Guo, Y. Huang*, Z. Nie*, S.Z. Yao. Analysis of copper nanoparticles toxicity based on a stress-responsive bacterial biosensor array. Nanoscale, 2013, 5, 653-662.
18.X.H. Xu, J. Zhou, X. Liu, Z. Nie*, M. Qing, M.L. Guo, S.Z. Yao, Aptameric Peptide for One-Step Detection of Protein Kinase, Anal. Chem. 2012, 84, 4746-4753.
19.K.Y. He, W. Li, Z. Nie*, Y. Huang, Z.L. Liu, L.H. Nie, S.Z. Yao, Enzyme-Regulated Activation of DNAzyme: A Novel Strategy for Label-Free Colorimetric DNA Ligase Assay and Ligase-Based Biosensing, Chem. Eur. J. 2012, 18, 3992-3999.
20.Q.P. Shen, S.Y. Tang, W.H. Li, Z. Nie*, Z.L. Liu, Y. Huang, S.Z. Yao, Simple, A novel DNA-templated click chemistry strategy for fluorescent detection of copper(II) ions, Chem. Commun. 2012, 48, 281–283.
21.W. Li, Z. Nie*, K.Y. He, X.H. Xu, Y. Li, Y. Huang, S.Z. Yao, Simple, Rapid and Label-free Colorimetric Assay for Zn2+ Based on Unmodified Gold Nanoparticles and Specific Zn2+ binding Peptide, Chem. Commun. 2011, 47, 4412 - 4414.
22.X.H. Xu, X. Liu, Z. Nie*, Y.L. Pan, M.L. Guo, S.Z. Yao, Label-free Fluorescent Detection of Protein Kinase Activity Based on the Aggregation Behavior of Unmodified Quantum Dots. Anal. Chem. 2011, 83, 52–59.
23.W. Li, Z.L. Liu, H. Lin, Z. Nie*, J.H. Chen*, X.H. Xu, S.Z. Yao, Label-Free Colorimetric Assay for Methyltransferase Activity Based on a Novel Methylation-Responsive DNAzyme Strategy. Anal. Chem. 2010, 82, 1935–1941.
24.Q.P. Shen, Z. Nie*, M.L. Guo, C.J. Zhong, B. Lin, W. Li, S.Z. Yao, Simple and rapid colorimetric sensing of enzymatic cleavage and oxidative damage of single-stranded DNA with unmodified gold nanoparticles as indicator. Chem. Commun. 2009, 919-931.
25.X.H. Xu, Z. Nie*, J.H. Chen*, Y.C. Fu, W. Li, Q.P. Shen, S.Z. Yao, DNA-based electrochemical strategy for label-free monitoring the activity and inhibition of protein kinase. Chem. Commun. 2009, 6946-6948.
26.C.Y. Deng, J.H. Chen*, Z. Nie*, M.D. Wang, X.C. Chu, X.L. Chen, X.L. Xiao, C.Y. Lei, S.Z. Yao, ImpedimetricAptasensor with Femtomolar Sensitivity Based on the Enlargement of Surface-Charged Gold Nanoparticles. Anal. Chem. 2009, 81, 739-745.
27.C.Y. Deng, J.H. Chen*, L.H. Nie, Z. Nie*, S.Z. Yao, Sensitive BifunctionalAptamer-Based Electrochemical Biosensor for Small Molecules and Protein. Anal. Chem. 2009, 81, 9972-9978.