葛瑞光

Submitted on 周一, 10/30/2017 - 20:56


性别
男

电子邮件
gerg@mail.sysu.edu.cn

职称
副教授

导师类型
博士生导师

学历
哲学博士

学科方向
0710生物学-10生物化学与分子生物学


研究方向
与疾病相关的金属蛋白质组学和重要蛋白质的生物化学

个人经历
1999年中国石油大学（华东）理学学士；
2002年南开大学理学硕士；
2006年香港大学哲学博士；
2006-2007香港大学高级研究助理；
2007-2008美国华盛顿大学圣路易斯分校霍华德修斯医学研究所博士后；
2008年5月起中山大学生命科学学院“****”副教授，博士生导师。

讲授课程
《生物化学II》
《研究型实验系列—金属蛋白质研究》
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学术成就
1. 在Acc Chem Res, J Am Chem Soc, Proteomics, BBA-Mol Cell Res等杂志发表论文30余篇，其中通讯作者文章15篇，第一作者文章11篇；文章被引用>1520次(2018.5)，其中被影响因子超过9分的论文引用超过120次，H-index 19；
2. 应邀参与了科学出版社一本中文专著以及Wiley和Royal Society of Chemistry杂志社两本外文专著的撰写；应邀为Acc Chem Res, Curr Drug Metab, Metallomics以及Biometals等杂志撰写综述；获得Metallomics金属组学中国特刊约稿; 相关成果被Faculty of 1000，Health & Medicine Week以及Med. Hypotheses等专文评价；
3. 担任国际期刊Immuno-Gastroenterology编委（2011-）；担任JBIC、JPR、Omics、Metallomics、Chem Commun.等10余种杂志审稿人；荷兰科学研究委员会基金项目外审专家；
4. 工作被写入国外的教科书中：2014年牛津大学出版的由M. Weller等所编写的《Inorganic Chemistry》（第六版）的第825页对我们实验室在含铋金属药物的作用机制方面的工作做了引用，2011年Wiley-VCH出版的由E. Alessio编著的《Bioinorganic Medicinal Chemistry》的第10页也引用我们实验室关于铋剂与病原体内蛋白质相互作用的工作；
5. 2011年获评为首届广州珠江科技新星

论文专著
2004年
[1] Ge, R., Lin, H., Xu, X., Sun, X., Lin, H.,* Zhu, S., Ji, B., Li, F., and Wu, H. (2004) Catalysis of phosphoryl transfer from adenosine-5’-triphosphate (ATP) by trinuclear ‘chelate’ complexes. J. Inorg. Biochem. 98, 917-924;
[2] Sun, X., Sun, H., Ge, R., Richter, M., Woodworth, R. C., Mason, A. B., and He, Q.-Y.* (2004) The low pKa value of iron-binding ligand Tyr188 and its implication in iron release and anion binding of human transferrin. FEBS Lett. 573, 181-185;
?2006年
[3] Ge, R., Watt, R. M., Sun, X., Tanner, J. A., He, Q.-Y., Huang, J.-D.,* and Sun, H.* (2006) Expression and characterization of a histidine-rich protein, Hpn: potential for Ni2+ storage in Helicobacter pylori. Biochem. J. 393, 285-293;
[4] Ge, R., Zhang, Y., Sun, X., Watt, R. M., He, Q.-Y., Huang, J.-D.,* Wilcox, D. E., and Sun, H.* (2006) Thermodynamic and kinetic aspects of metal binding properties of the histidine-rich protein, Hpn. J. Am. Chem. Soc. 128, 11330-11331;
2007年
[5] Ge, R., Sun, X., Gu, Q., Watt, R. M., Wong, B. C.-Y., Xia, H. H., Huang, J.-D., He, Q.-Y.,* and Sun, H.* (2007) A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori. J. Biol. Inorg. Chem. 12, 831-842;
[6] Ge, R. and Sun, H.* (2007) Bioinorganic chemistry of bismuth and antimony: target sites for metallodrugs. Acc. Chem. Res. 40, 267-274;
?2008年
[7] Sun, X., Ge, R., Chiu, J.-F., Sun, H., and He, Q.-Y.* (2008) Identification of proteins related to nickel homeostasis in Helicobacter pylori by immobilized metal affinity chromatograph and two-dimensional gel electrophoresis. Metal-Based Drugs 2008: 289490;
[8] Cun, S., Li, H., Ge, R., Lin, M. C. M., and Sun, H.* (2008) A histidine- and cysteine-rich metal binding domain at the C-terminus of GroES homologue from Helicobacter pylori: implication for nickel homeostasis and bismuth susceptibility. J. Biol. Chem. 283, 15142-15151;
[9] Sun, X., Ge, R., Chiu, J.-F., Zu, Y., Sun, H., and He, Q.-Y.* (2008) Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion. FEBS Lett. 582, 1351-1354;
?2009年
[10] Ge, R., and Sun, H.* (2009) Metallomics: an integrated biometal science. Sci. China Ser. B--Chem. 52, 2055-2070;
[11] Ge, R., Sun, X., and He, Q.-Y.* (2009) Iron acquisition by Streptococcus species: an updated review. Front. Biol. China 4, 392-401;
[12] 葛瑞光、陈卓、孙红哲*（2009）金属组学：研究生命体系中金属离子的前沿交叉学科。中国科学 B辑：化学，39，590-606;
[13] Xia, H., Qi, Y., Ng, S. S., Chen, X., Chen, S., Fang, M., Li, D., Zhao, Y., Ge, R., Li, G., Chen, Y., He, M. L., Kung, H. F., Lai, L., and Lin M. C.* (2009) MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. Biochem. Biophys. Res. Commun. 380, 205-210;
[14] Xia, H., Qi, Y., Ng, S. S., Chen, X., Chen, S., Ge, R., Li, G., Chen, Y., He, M. L., Kung, H. F., Lai, L., and Lin M. C.* (2009) MircroRNA-146b inhibits glioma cell migration and invasion by targeting MMPs. Brain Res. 1269, 158-165;
[15] Sun, X., Baker, H. M., Ge, R., Sun, H., He, Q.-Y.,* and Baker, E. N.* (2009) Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes. Biochemistry 48, 6184-6190;
[16] Sun, X., Ge, R., Cai, Z., Sun, H., and He, Q.-Y.* (2009) Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2. J. Inorg. Biochem. 103, 1074-1081;
?2010年
[17] Ge, R., Chu, I. K., and Sun, H.* (2010) Nuclear-based metallomics in metal-based drugs. In Advanced nuclear analytical techniques for metallomics and metalloproteomics. Eds. Chen C., Chai, Z., and Gao, Y., Royal Society of Chemistry, London, UK; pp 265~298;
[18] Sun, X., Ge, F., Xiao, C. L., Yin, X. F., Ge, R., Zhang, L. H. and He, Q.-Y.* (2010) Phosphoproteomic analysis reveals the multiple roles of phosphorylation in pathogenic bacterium Streptococcus pneumonia. J. Proteome Res. 9, 275-282;
[19] Sun, X., Ge, R., Zhang, D., Sun, H. and He, Q.-Y.* (2010) Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter of Streptococcus pyogenes. J. Biol. Inorg. Chem. 15, 1265-1273;
?2011年
[20] Sun, X., Xiao, C. L., Ge, R., Yin, X., Li, H., Li, N., Yang, X., Zhu, Y., He, X. and He, Q.-Y.* (2011) Putative copper- and zinc-binding motifs in Streptococcus pneumoniae identified by immobilized metal affinity chromatography and mass spectrometry. Proteomics, 11, 3288-3298;
[21] Tsang, C.-N., Ge, R. and Sun, H.* (2011) Metallomics and metalloproteomics for arsenic, antimony and bismuth. In Biological chemistry of arsenic, antimony and bismuth. Eds. Sun, H., John Wiley & Sons; pp 353~376;
[22] Ge, R*., Sun, X., Xiao, C., Yin, X., Shan, W., Chen, Z., and He, Q.-Y.* (2011) Phosphoproteome analysis of the pathogenic bacterium Helicobacter pylori reveals over-representation of tyrosine phosphorylation and multiply phosphorylated proteins. Proteomics 11, 1449-1461;
[23] Ge, R.*, Sun, X., Wang, D., Zhou, Q. and Sun, H. (2011) Histidine-rich protein Hpn from Helicobacter pylori forms amyloid-like fibrils in vitro and inhibits the proliferation of gastric epithelial AGS cells. BBA-Mol. Cell Res. 1813, 1422-1427;
[24] Ge, R., Sun, X., and He, Q.-Y.* (2011) Overview of the metallometabolomic methodology for metal-based drug metabolism. Curr. Drug Metab. 12, 287-299;
[25] Ge, R.*, and Sun, X. (2011) Iron trafficking system in Helicobacter pylori. Biometals 25, 247-258;
[26] Ge, R.* and Sun, X. (2011) The in vivo functions of a histidine-rich protein Hpn in Helicobacter pylori: linking gastric and Alzheimer’s disease together? Med. Hypothesis 77, 788-890;
[27] Ge, R.* and Shan, W. (2011) Bacterial phosphoproteomic analysis reveals the correlation between protein phosphorylation and bacterial pathogenicity. Genomics Proteomics Bioinformatics 9, 119-127;
?2012年
[28] Ge, R.*, Chen, Z., and Zhou, Q. (2012) The actions of bismuth in the treatment of Helicobacter pylori infections: an update. Metallomics 4, 239-243;
[29] Ge, R.* (2012) Proton pump inhibitors are double-edged sword in the treatment of Helicobacter pylori infections? Annals Gastroenterol. 25, 87-88;
[30] Chen, Z., Zhou, Q. and Ge, R.* (2012) Inhibition of fumarase by bismuth(III): implications for the tricarboxylic acid cycle as a potential target of bismuth drugs in Helicobacter pylori. Biometals 25, 95-102;
[31] 葛瑞光 （2012）第五章 蛋白质体外研究—结构与功能，《功能蛋白研究》，科学出版社;
?2013年
[32] Wang, D., Luo, B., Shan, W., Hao, M., Sun, X. and Ge, R.* (2013) The effects of EF-Ts and bismuth on EF-Tu in Helicobacter pylori: implications for an elegant timing for the introduction of EF-Ts in the elongation and EF-Tu as a potential drug target. Metallomics 5(7), 888-895;
[33] Ge, R.*, Wang, D., Hao, M. and Sun, X. (2013) Nickel tranfficking system responsible for urease maturation in Helicobacter pylori. World J. Gastroentro. 19(45), 8211-8218;
?2014年
[34] Zhou, Q., Qi, S., Sun, X. and Ge, R.* (2014) The interactions of a histidine-rich protein Hpn with the membrane mimics: implications for pathological roles of Hpn in Helicobacter pylori. Helicobacter 19(2), 129-135;
[35] Ge, R.*, Wang, D., Hao, M. and Sun, X. (2014) Nickel tranfficking system responsible for urease maturation in Helicobacter pylori. In World Clinical Gastroenterology. Eds. Ma, L., Chua, M.-S. and So, S., Baishideng Publishing Group Inc.; pp 2132~2139;
[36] Ge, R.*, and Sun, X.* (2014) Iron acquisition and regulation systems in Streptococcus species. Metallomics 6(5), 996-1003;
?2015年
[37] Huang, D., Qiu, S., Ge, R., He, L., Li, M., Li, Y. and Peng, Y.* (2015) miR-340 suppresses glioblastoma multiforme. Oncotarget 6(11) 9257-9270;
?2016年
[38] Shan, W., Kung, H.F. and Ge, R.* (2016) Comparison of iron-binding ability between Thr70-NapA and Ser70-NapA of Helicobacter pylori. Helicobacter 21(3) 192-200;
[39]?Liu SH, Tang YT*, Qiu RL, Ying RR, Ge, R. and Ji XH (2016) Responses of carbonic anhydrase to cadmium in the zinc/cadmium hyperaccumulator Picris divaricate Vant. Pedosphere 26(5) 709-716;
2017年
[40]?Wu J, Jia Q, Wu S, Zeng H, Sun Y, Wang C, Ge R.*, Xie W.* (2017)?The crystal structure of the Pyrococcus abyssi mono-functional methyltransferase PaTrm5b. BBRC 493(1) 240-245;
2018年
[41]?Liu YT, Pan Y, Lai F, Yin XF, Ge R*, He QY*, Sun X.* (2018) Comprehensive analysis of the lysine acetylome and its potential regulatory roles in the virulence of Streptococcus pneumoniae. J. Proteomics 176 46-55;