联系方式办公电话：-808
电子邮箱：jinjing@mail.sysu.edu.cn
办公地址：广州大学城外环东路132号中山大学药学院，510006
?简单介绍金晶，女，中山大学药学院副教授，博士生导师，广东省特支计划百千万工程青年拔尖人才，中国药理学会青年药理学家奖，刘昌孝院士人才奖获得者。1997-2004年于华中科技大学获学士和硕士学位，2007-2010年于中山大学获博士学位；2004年7月起至今于中山大学药学院工作，历任助教、讲师，副教授。主要从事药物代谢与毒理学研究工作。近年来，主持国家自然科学基金3项，省市级科研项目多项，作为课题骨干参加国家重点研发计划和重大新药创制等项目。在国内外重要学术期刊杂志上发表高水平I收录论文50余篇，以第一作者/通讯作者发表高水平收录期刊论文30余篇，获授权专利2项。任国家自然科学基金同行评审专家；任多种药理与毒理学国际学术期刊特邀审稿人和学术团体委员。
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研究方向1.? ?药物的毒性作用机制及其干预策略研究
2.? ?药物代谢及临床合理用药研究
3.? ?中药的毒-效作用调控及靶标发现
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教育与工作经历1. 1997.09 - 2001.06? 华中科技大学同济医学院 药学院? 学士学位
2.? 2001.09 - 2004.06? 华中科技大学同济医学院 药学院? 硕士学位
3.? 2007.09 - 2010.06? 中山大学 药学院? 博士学位
4.? 2004.07 - 至今?? ? ? ? 中山大学药学院工作
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科研项目（主持）1.???? 国家自然科学基金，面上项目，2020/01-2023/12，项目负责人
2.???? 国家自然科学基金，面上项目，2016/01-2019/12，项目负责人
3.???? 国家自然科学基金，青年基金，2012/01-2014/12，项目负责人
4.???? 广东省自然科学基金，面上项目，2020/01-2022/12，项目负责人
5.???? 广东省科技计划项目，2017/01-2019/12，项目负责人
6.???? 中山大学青年教师培育计划，2016/01-2018/12，项目负责人
7.???? 广东省医学科研基金，面上项目，2012/6-2015.6，项目负责人
8.???? 广东省中医药局科研基金，面上项目，2015/01-2016/12，项目负责人
9.???? 国家自然科学基金，面上项目，2013/01-2016/12，合作单位负责人
10.?? 广州市珠江科技新星项目协作课题，2013/01-2013/12，项目负责人
11.? ?横向课题：系列保健产品的毒性评价，83万，2019-2023，项目负责人
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教学工作讲授《药学分子生物学》、《药物毒理学》、《生物化学与基础分子生物学实验》、《药代动力学实验》等药学本科课程
参编《药物毒理学》、《临床药理学》、《生物化学与基础分子生物学实验》、《药代动力学实验》等教材
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论著（第一或通讯作者论文）
1.???????? Yang B, Xuan SX, Ruan QF, Jiang SQ, Cui H, Zhu LP, Luo X, Jin J*, Zhao ZX*. UPLC/Q-TOF-MS/MS-based metabolomics revealed the lipid-lowering effect of Ilicis Rotundae Cortex on high-fat diet induced hyperlipidemia rats. Journal of Ethnopharmacology, 2020,256: 112784.
2.???????? Wang?DF,?Yu?WB,?Cao?L,?Xu?CC,?Tan?GY,?Zhao?ZX,?Huang?M*,?Jin?J*, Comparative pharmacokinetics and tissue distribution of cryptotanshinone, tanshinone IIA, dihydrotanshinone I, and tanshinone I after oral administration of pure tanshinones and liposoluble extract of Salvia miltiorrhiza to rats, Biopharmceutics & Drug Disposition, 2020, 41(1-2):54-63.
3.???????? Bai?XP, Gou XL?,?Cai PH,?Xu CC,?Cao L,?Zhao ZX,?Huang M,?Jin J*, Sesamin Enhances Nrf2-Mediated Protective Defense against Oxidative Stress and Inflammation in Colitis via AKT and ERK Activation, Oxidative Medicine and Cellular Longevity, 2019:**.?doi: 10.1155/2019/**.?
4.???????? Chen YB, Zhou ZY, Li GM, Xiao CX, Yu WB, Zhong SL*, Cai YF*, Jin J*, Huang M, Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients, Acta Pharmacologica Sinica, 2019, 40(6):762-768.
5.???????? Bai XP, Xu CC, Wen DS, Chen YB, Li HL, Wang XD, Zhou LM*, Huang M*, Jin J*, Polymorphisms of peroxisome proliferator-activated receptor γ (PPARγ) and cluster of differentiation 36 (CD36) associated with valproate-induced obesity in epileptic patients, Psychopharmacology, 2018, 235(9):2665-2673.?
6.???????? Hong WP, Cai PH, Xu CC, Cao D, Yu WB, Zhao ZX, Huang M, Jin J*, Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System. Frontiers in Pharmacology, 2018, 9:43, doi:? 10.3389/fphar.2018.00043.
7.???????? Yu WB, Xu CC, Li GM, Hong WP, Zhou ZY, Xiao CX, Zhao YQ, Cai YF, Huang M, Jin J*. Simultaneous determination of trimethylamine N-oxide, choline, betaine by UPLC-MS/MS in human plasma: An application in acute stroke patients. Journal of Pharmaceutical and Biomedical Analysis, 2018, 152(4): 179-187.
8.???????? Cao D, Xu CC, Xue YY, Ruan QF, Yang B, Liu ZQ, Cui H, Zhang L, Zhao ZX*, Jin J*. The therapeutic effect of Ilex pubescens extract on blood stasis model rats according to serum metabolomics. Journal of Ethnopharmacology, 2018,227:18-28.
9.???????? Bai XP, Hong WP, Cai PH, Chen YB, Xu CC, Cao D, Yu WB, Zhao ZX, Huang M, Jin J*. Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis. Toxicology and Applied Pharmacology, 2017, 324(6): 12-25.
10.????? Tan QL, Qiu MS, Cao D, Xiong TQ, Zhang L, Zhou L, Rong L, Zhou JS, Jin J*, Zhao ZX*. Triterpenoids with Antiplatelet Aggregation Activity from the Roots of Ilex pubescens. Planta Med, 2017,83(9):797-804.
11.????? Bai XP, Chen YB, Hou XY, Huang M*, Jin J*. Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters. Drug Metabolism Reviews. 2016, 48(4):541-567
12.????? Liu R, Zhou ZY, Chen YB, Li JL, Yu WB, Chen XM, Zhao M, Zhao YQ, Cai YF*, Jin J*, Huang M*. Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke. Acta Pharmacologica Sinica. 2016, 37(7): 882-888
13.????? Wang WW, Guan CW, Sun XZ, Zhao ZX, Li J, Fu XL, Qiu YW, Huang M, Jin J*, Huang ZY*. Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway. Phytomedicine 2016，23：589-596
14.????? Chen XM, Zhao ZX, Chen YB, Gou XL, Zhou ZY, Zhong GP, Cai YF, Huang M, Jin J*. Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats. Journal of Ethnopharmacology. 2016, 192:362-369.
15.????? Qiu MS, Cao D, Gao YH, Li SH, Zhu JP, Yang B, Zhou L, Zhou Y, Jin J*, Zhao ZX *, New clerodane diterpenoids from Croton crassifolius, Fitoterapia, 2016, 108: 81–86.
16.????? Xia C, Bai XP, Hou XY, Gou XL Wang YT, Zeng H, Huang M, Jin J*. Cryptotanshinone reverses cisplatin resistance of human lung carcinoma A549 cells through down-regulating Nrf2 pathway, Cellular Physiology and Biochemisty, 2015, 37：816-824.
17.????? Hou XY, Bai XP, Gou XL, Zeng H, Xia C, Zhuang W, Chen XM, Zhao ZX, Huang M, Jin J*. 3',4',5',5,7-Pentamethoxyflavone sensitizes cisplatin-resistant A549 cells to cisplatin by inhibition of Nrf2 pathway, Molecules and Cells, 2015, 38(5): 396-401.
18.????Liu B, Gou XL, Bai XP, Hou XY, Li DS, Zhong GP, Jin J*, Huang M*. Simultaneous determination of seven taxoids in rat plasma by UPLC–MS/MS and pharmacokinetic study after oral administrationof Taxus yunnanensis extracts, Journal of Pharmaceutical and Biomedical Analysis, 2015, 107: 346-354.

19.? ??Jin J, Sun XZ, Zhao ZX, Wang WW, Qiu YW, Fu XL, Huang M, Huang ZY*. Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity. Phytomedicine, 2015, 22(10):894-901.

20.?????Jin J, Li M., Wang WW, Sun XZ, Li J, Zhao ZX, Huang M, Huang ZY*. Protective effect of Wuzhi tablet (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response. Phytomedicine, 2015, 22(5):528-535.
21.????? Chen XM, Jin J*, Chen YB, Peng LL, Zhong GP, Li JL, Bi HC, Cai YF, Huang M*. Effect of scutellarin on the metabolism and pharmacokinetics of clopidogrel in rats. Biopharmceutics & Drug Disposition, 2015,36(1): 64-68.
22.????? Fan Z, Zhou L, Xiong TQ, Zhou J S, Li QG, Tan QL, Zhao ZX*, Jin J*. Antiplatelet aggregation triterpene saponins from the barks of Ilex rotunda. Fitoterapia, 2015,101: 19-26.
23.????? Fan Z^#,Jin J^#, Lin CZ, Zhu CC, Yang T, Yang B, Zhu JP, Zhao ZX*. New Flavanol Glucosides from Abacopteris aspera (PRESL) CHING. Helvetica Chimica Acta, 2015,98(1): 108-115.
24.? ?Yang B, Yang T, Tan Q, Zhu J, Zhou L, Xiong T, Zhao Z*, Jin J*.?Antiplatelet aggregation triterpene saponins from the leaves of Ilex kudingcha. Phytochemistry Letters, 2015,13: 302-307?
25.????Jin J*, Xiong TQ, Hou XY, Sun XZ, Liao JY, Huang ZY, Huang M, Zhao ZX*. Role of Nrf2 activation and NF-kappaB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice. Food and Chemical Toxicology, 2014,73: 95-104.
26.????? Li J, Shen FH, Guan CW, Wang WW, Sun XZ, Fu XL, Huang M, Jin J*, Huang ZY*. Activation of Nrf2 protects against triptolide-induced hepatotoxicity. PLoS One, 2014,9(7): e100685.
27.?????Jin J, Cai DK, Bi HC, Zhong GP, Zeng H, Gu LQ, Huang ZY, Huang M*. Comparative pharmacokinetics of paclitaxel after oral administration of Taxus yunnanensis extract and pure paclitaxel to rats. Fitoterapia, 2013,90: 1-9.

28.?????Jin J, Liu J, Chen JY, Zhao LZ, Ma Z, Chen X, Huang M, Zhong GP*. Bioequivalence evaluation of two tablet formulations of entecavir in healthy chinese volunteers: a single-dose, randomized-sequence, open-label crossover study. Arzneimittelforschung/Drug Research, 2012,62(3): 113-116.
29.?????Li J, Jin J*, Li M, Guan CW, Wang WW, Zhu SH, Qiu YW, Huang M, Huang ZY*. Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells. Toxicology Letters, 2012, 213(2): 194-202.
30.????? Zhu SH, Wang Y, Jin J*, Guan CW, Li M, Xi C, Ouyang ZZ, Chen MW, Qiu YW, Huang M, Huang ZY*. Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in human renal proximal tubular epithelial cells. Toxicology in Vitro, 2012,26(5): 663-671.
31.????? Zhu SH, Jin J*, Wang Y, Ouyang ZZ, Xi C, Li J, Qiu YW, Wan JZ, Huang M,Huang ZY*. The endoplasmic reticulum stress respionse is involved in apoptosis induced by aloe-emodin in HK-2 cells. Food and Chemical Toxicology, 2012,50(3-4): 1149-1158.
32.?????Jin J, Bi HC, Hu JQ, Zeng H, Zhong GP, Zhao LZ, Huang ZY, Huang M*. Effect of Wuzhi tablet (Schisandra sphenanthera extract) on the pharmacokinetics of paclitaxel in rats. Phytotherapy Research, 2011,25(8): 1250-1253.
33.?????Jin J, Bi HC, Hu JQ, Zhong GP, Zhao LZ, Huang ZY, Huang M*. Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats. Biopharmceutics & Drug Disposition, 2010, 31(4):264-268.
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获奖情况1. 2018年获刘昌孝院士人才奖
2. 2016年获中国药理学会青年药理学家奖
3. 2015年获《Food and Chemical Toxicology》杂志杰出审稿人奖，Certificate of Outstanding Contribution in Reviewing
4. 2014年获得中山大学医科本科教学中青年教师普通话授课大赛三等奖
5. 2011年获国际/中国药物代谢专业委员会，Best Presentation Award
6. 2011年获第十八届微粒体与药物代谢国际会议，中国青年科学家Travel Award
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其它热忱欢迎感兴趣的同学报读本研究组的硕士和博士研究生，也非常欢迎博士后、研究助理等优秀科研人员加入。