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电子邮箱：lizhm5@mail.sysu.edu.cn
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?简单介绍李卓明，中山大学药学院药理毒理实验室副教授、博士生导师，药理教研室副主任。2012年获香港大学心血管药理专业博士学位。主要从事心血管药理学研究，针对蛋白翻译后修饰（乙酰化、磷酸化、多聚核糖基化）对心血管系统功能的调控，开展心肌肥大、内皮功能障碍、动脉粥样硬化的发病机制和防治靶标研究。主持国家自然科学基金（面上项目+青年基金）、教育部博士点基金、广东省自然科学基金、广州市科技计划等各级科研项目8项。共发表高水平论文30余篇，其中以第一作者及通讯作者在Hypertension、Aging、Acta Physiologica等国际知名高水平期刊发表文章20余篇。曾获 “2019全国高等学校药学类专业青年教师教学能力大赛”特等奖、“2015中国药理学会教学与科普专业委员会第二届青年教师教学基本功竞赛”三等奖、“广东省药理学会第七届2015学术交流大会”青年优秀论文评比二等奖等奖项。任中国药理学会心血管药理专业委员会青年委员会副主任委员、全国卫生产业企业管理协会转化医学产业分会委员、广东省药理学会药物筛选与评价专业委员会秘书、广东省药理学会药理教育专业委员会常务委员。
?教学情况讲授《药理学》、《药理学实验》、《人体解剖生理学》、《人体解剖生理学实验》、《Pharmacology II》等药学本科课程，以及《心血管药理学》、《药理学研究进展》等研究生课程。担任《Pharmacology II》和《人体解剖生理学实验》课程负责人。
?论著专利 （第一/通讯作者论文）1.?TongLin ^#, Wenwei Luo ^#, Ziqing Li, Lili Zhang, Xinghan Zheng, Liting Mai, Wanqi Yang, Guimei Guan, Ziren Su, Peiqing Liu, Zhuoming Li ^*, Youliang Xie^*. Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3. Phytomedicine. 2020 Sep 19; 79:153350.
2.?Ziqing Li, Wenwei Luo, Shi Fang, Xinyi Chen, Tong Lin, Sihang Zhou, Lili Zhang, Wanqi Yang, Zhenzhen Li, Ye Jiantao, Wang Junjian, Peiqing Liu, Zhuoming Li ^*. Prostacyclin facilitates vascular smooth muscle cell phenotypic transformation via activating TP receptors when IP receptors are deficient. Acta Physiologica. 2020 Sep 4; e13555.
3.?Xiaolei Zhang ^#, Zhuoming Li ^#, Jiantao Ye, Jing Lu, Lingyu Linda Ye, ChunXiang Zhang, Peiqing Liu *, Dayue D. Duan *. Pharmacological and Cardiovascular Perspectives on the Treatment of COVID-19 with Chloroquine Derivatives and Beyond. Acta Pharmacologica Sinica. 2020 Sep 23;1-10.
4.?Sidong Cai, Panxia Wang, Tingting Xie, Zhenzhen Li, Jingyan Li, Rui Lan, Yanqing Ding, Jing Lu, Jiantao Ye, Junjian Wang, Zhuoming Li ^*, Peiqing Liu ^*.? Histone H4R3 symmetric di-methylation by Prmt5 protects against cardiac hypertrophy via regulation of Filip1L/β-catenin. Pharmacological Research. 2020 Jul 31;161:105104.
5.?Zhenzhen Li ^#, Xiaoying Zhang ^#, Zhen Guo, Yao Zhong, Panxia Wang, Jingyan Li, Zhuoming Li *, Peiqing Liu*. SIRT6 suppresses NFATc4 expression and activation in? cardiomyocyte hypertrophy. Frontiers in Pharmacology. 2019 Jan 8;9:1519.?
6.?Luo Wenwei ^#, Wang Yu ^#, Yang Hanwei, Dai Chunmei, Hong Huiling, Li Jingyan, Liu Zhiping, Guo Zhen, Chen Xinyi, He Ping, Li Ziqing, Li Fang, Jiang Jianmin, Liu Peiqing ^*, Li Zhuoming ^*. Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling. Aging (Albany NY). 2018 Jul 24;10(7):1722-1744.
7.?Yang Han-Wei ^#, Hong Hui-Ling ^#, Luo Wen-Wei, Dai Chun-Mei, Chen Xin-Yi, Wang Lu-Ping,?Li Qian, Li Zi-Qing, Liu Pei-Qing ^*,?Li Zhuo-Ming ^*. mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway. Acta Pharmacol Sin. 2018 Dec;39(12):1837-1846.
8.?Li Zhuo-Ming ^#, Xu Suo-Wen ^#, Liu Pei-Qing ^*. Salvia miltiorrhiza Burge (Danshen): a golden herbal medicine in cardiovascular therapeutics. Acta Pharmacologica Sinica. 2018 May;39(5):802-824. (ESI高被引论文)
9.?Jing Lu, Renwei Zhang, Huiqi Hong, Zuolong Yang, Duanping Sun, Xiuli Fang, Shuya Sun, Jiantao Ye, Zhuoming Li ^*, Peiqing Liu ^*. The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy. Biochim Biophys Acta-Molecular Cell Research.?2016 Dec;1863(12):3027-3039.
10.?You Jia,?Yue Zhongbao,?Chen Shaorui,?Chen Yanfang,?Lu Xia,?Zhang Xiaoying,?Shen Peiye,?Li Jingyan,?Han Qingfang,?Li Zhuoming ^*-,?Liu Peiqing ^*-. Receptor-Interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes. Acta Physiol (Oxf).?2017 May;220(1):58-71.
11.?Zhang Xiaoying, Li Wei, Shen Peiye, Feng Xiaojun, Yue Zhongbao, Lu Jing, You Jia, Li Jingyan, Gao Hui, Fang Shi, Li Zhuoming ^*-, Liu Peiqing ^*--. STAT3 suppression is involved in the protective effect of SIRT6 against cardiomyocyte hypertrophy. Journal of Cardiovascular Pharmacology. 2016 Sep;68(3):204-14.
12.?Li Jingyan, Gao Hui, Huang Junying, Wang Panxia, Huang Yi, Luo Wenwei, Zhang Xiaoying, Shen Peiye, You Jia, Cai Sidong, Li Zhuoming ^*, Liu Peiqing ^*. PKCζ interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy. Journal of Pharmacological Sciences. 2016 Sep;132(1):15-23.
13.?Liu Zhiping, Wang Jiaojiao, Huang Xiaoyang, Li Zhuoming ^*, Liu Peiqing ^*. Deletion of SIRT6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice. Translational Research. 2016 Jun;172:18-29.e2.
14.?Liu Xue-ping ^#, Gao Hui ^#, Huang Xiao-yang, Chen Yan-fang, Feng Xiao-jun, He Yan-hong, Li Zhuo-ming ^*, Liu Pei-qing ^*. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha protects cardiomyocytes from hypertrophy by suppressing calcineurin-nuclear factor of activated T cells c4 signaling pathway. Translational Research.?2015, 166(5):459-473.e3
15.?Gao Hui ^#,?Feng Xiao-Jun ^#,?Li Zhuo-Ming ^#,?Li Min,?Gao Si,?He Yan-Hong,?Wang Jiao-Jiao,?Zeng Si-Yu,?Liu Xue-Ping,?Huang Xiao-Yang,?Chen ?Shao-Rui ^*,?Liu Pei-Qing ^*. Downregulation of adipose triglyceride lipase promotes cardiomyocyte hypertrophy by triggering the accumulation of ceramides. Arch Biochem Biophys. 2015, 565:76-88.
16.?MinLiu, Jiantao Ye, Si Gao, Wei Fang, Hong Li, Biao Geng, Jian Zou, Xi Chen, Shaorui Chen, Luankun Zhang, Zhongbao Yue, Yunzi Ma, Hui Gao, Zhuoming Li^*, Peiqing Liu^*. Salvianolic acid B protects cardiomyocytes from angiotensin II-induced hypertrophy via inhibition of PARP-1. Biochem Biophys Res Commun. 2014, 444(3):346-53.
17.?Zhuoming Li, Yu Wang, Ricky Y.K. Man, Paul M. Vanhoutte^*. Up-regulation of heme oxygenase-1 potentiates EDH-mediated relaxations in the mesenteric artery of the spontaneously hypertensive rat. American journal of physiology-Heart and circulatory physiology. 2013, 305(10):H1471-83.
18.?Zhuoming Li, Yu Wang, Paul M. Vanhoutte^*. Up-regulation of Heme oxygenase-1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Hypertension. 2011, 58:926–934.
19.?Zhuoming Li, Yu Wang, Paul M. Vanhoutte^*. Epigallocatechin gallate elicits contractions of the isolated aorta of the aged spontaneously hypertensive rat. Basic Clin Pharmacol Toxicol. 2011, 109(1):47-55.
20.?Winnie Zhuoming Li, Jun Li, Cathy Wenchuan Bi, Anna W. Cheng, Wen Huang, Ran Duan, Roy C. Choi, Ivy S. Chen, Kuijun Zhao, Tina T. Dong, Jinao Duan, Karl W. Tsim^*. Can Rhizoma Chuanxiong replace Radix Angelica sinensis in the traditional Chinese herbal decoction Danggui Buxue Tang? Planta Medica. 2009, 75(6):602-6.
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参编书籍及教材1.?参编《药理学实验实训教程》. 科学出版社，2015年6月出版，ISBN 978-7- 03-044688-6.??
2.?参编《药理学Pharmacology（英文版）》. 人民卫生出版社. 全国高等学校药学类专业规划教材. 2017年8月出版，ISBN978-7-117-24120-5/R·24121 .?
3.?参编《心脑血管药理学》. 科学出版社. 2019年3月第三版. ISBN978-7-03-060677-8.?
4.?参编《高等药理学》. 科学出版社. 2019年7月出版. ISBN 978-7-03-061139-0.?
5.?副主编《药物筛选与成药性评价基础与实践》. 中山大学出版社. 普通高等教育“十三五”规划教材. 2019年1月出版. ISBN 978-7-306-06444-8.?
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获奖情况1.?“2019全国高等学校药学类专业青年教师教学能力大赛”特等奖
2. “2019全国高等学校药学类专业青年教师微课教学大赛”特等奖
3.? 2015年中山大学优秀班主任/学生导师
4.?“2015中国药理学会教学与科普专业委员会第二届青年教师教学基本功竞赛”三等奖
5.?“广东省药理学会第七届2015学术交流大会”青年优秀论文评比二等奖
6.“2011中国药理学会第十一次全国学术大会、中国药理学会——香港药理学会英文学术报告优秀青年英文报告”三等奖
7.1^st?prize award of outstanding oral presentation in Institute of Cardiovascular Science and Medicine 14^th?Annual Scientific Meeting?（2010）
8.Outstanding oral presentation award in Hong Kong Pharmacology Society 13^th?Annual Scientific Meeting（2010）
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