简单介绍

路静，女，博士，中山大学药学院副教授，硕士生导师，广东省****基金获得者。兼任中国药理学会心血管药理专业委员会青年委员会常务委员、广东省药理学会心血管药理专业委员会常务委员、广东省药理学会药物筛选与评价专业委员会常务委员等。目前主要从事心血管药理学研究，寻找心肌保护的新靶标、对靶标进行识别和示踪、并以发现的关键靶标筛选先导化合物。作为项目负责人主持国家自然科学基金青年项目、广东省自然科学基金****项目等7项。迄今共发表学术论文50余篇，其中以第一作者或通讯作者发表学术论文23篇，包括Cell Death Differ、Coordin Chem Rev、Biosens Bioelectron、Acta Pharm Sin B、ACS Appl Mater Inter等学术期刊，期刊封面论文2篇，影响因子大于10分的论文5篇。担任Acta Pharm Sin B、Biochem Pharmacol等学术期刊审稿人。荣获2019年度高等学校科学研究优秀成果奖科学技术进步奖二等奖(第八完成人)、广东省药理学会2017学术大会青年优秀论文一等奖等。


ORCID ID-Jing Lu: https://orcid.org/0000-0001-5766-2775
研究方向

1. 心血管治疗新靶标的发现和确认
2. 心血管创新药物研发
3. 核酸适配体识别心衰新靶标

教育经历

2007-9至2011-7，山东第一医科大学药学院，中药学，理学学士
2011-9至2014-6，中山大学药学院，药理学，理学硕士，导师：刘培庆教授
2014-9至2017-6，中山大学药学院，药理学，理学博士，导师：刘培庆教授
工作经历

2017-7至2020-7，中山大学药学院，药理学，特聘副研究员
2020-7至现在，中山大学药学院，药理学，副教授，硕士生导师
学术任职

1.?中国药理学会心血管药理专业委员会青年委员会，常务委员
2. 广东省药理学会心血管药理专业委员会，常务委员
3. 广东省药理学会药物筛选与评价专业委员会，常务委员
4. 中国药理学会表观遗传药理学专业委员会，委员
5. 广东省药理学会药理教育专业委员会，委员

荣誉获奖

1. 中华医学会医学科学技术奖（8/8），三等奖，2020
2. 教育部高等学校科学研究优秀成果奖科学技术进步奖（8/11），二等奖，2019
3. 中国药理学会第十一届海峡两岸心血管科学研讨会青年优秀论文，二等奖，2017
4. 广东省药理学会第八届会员代表大会暨2017学术大会青年优秀论文，一等奖，2017
科研项目

1. 国家自然科学基金青年项目，2019-1至2021-12，在研，主持
2. 广东省自然科学基金****项目，2021-1至2024-12，在研，主持
3. 广州市科技计划项目，2021-4至2023-3，在研，主持
4. 广东省自然科学基金面上项目，2019-10至2022-09，在研，主持
5. 中山大学青年教师培育项目，2019-1至2021-12，在研，主持
6. 广东省中医药局科研项目，2019-1至2021-1，在研，主持
7. 广东省医学科研基金项目，2018-7至2020-6，在研，主持
近五年的科研论文 (^#第一作者, *通讯作者)

2021年

1. Siyi Chen, Jing Lu*, Tianhui You*, Duanping Sun*, Metal-organic frameworks for improving wound healing, Coordination Chemistry Reviews, 2021, 439: 213929.?
2. Jing Lu, Suowen Xu, Yuqing Huo, Duanping Sun, Yuehuai Hu, Junjian Wang, Xiaolei Zhang, Panxia Wang, Zhuoming Li, Mengya Liang, Zhongkai Wu*, Peiqing Liu*, Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3, Cell Death and Differentiation, 2021, DOI: 10.1038/s41418-021-00789-w.?
3. Panxia Wang, Minghui Wang, Yuehuai Hu, Jianxing Chen, Yanjun Cao, Cui Liu, Zhongkai Wu, Juan Shen*, Jing Lu*; Peiqing Liu*, Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression, Acta Pharmaceutica Sinica B, 2021,11(3): 680-693.?
2020年

4. Duanping Sun^#,*, Dingcao Yang^#, Ping Wei, Bing Liu, Zuanguang Chen, Luyong Zhang*, Jing Lu*, One-step electrodeposition of silver nanostructures on 2D/3D metal-organic framework ZIF-67: Comparison and application in electrochemical detection of hydrogen peroxide, ACS Applied Materials & Interfaces, 2020, 12(37): 41960-41968.
5. Jing Lu, Yuehuai Hu, Panxia Wang, Peiqing Liu, Zuanguang Chen, Duanping Sun*, Electrochemical biosensor based on gold nanoflowers-encapsulated magnetic metal-organic framework nanozymes for drug evaluation with in-situ monitoring of H₂O₂ released from H9C2 cardiac cells, Sensors and Actuators B: Chemical, 2020, 311: 127909.?
6. Panxia Wang^#, Rui Lan^#, Zhen Guo^#, Sidong Cai, Junjian Wang, Quan Wang, Zeyu Li, Zhenzhen Li, Qianqian Wang, Jingyan Li, Zhongkai Wu, Jing Lu*, Peiqing Liu*, Histone demethylase JMJD3 mediated doxorubicin-induced cardiomyopathy by suppressing SESN2 expression, Frontiers in Cell and Developmental Biology, 2020, 8: 548605.?
2019年

7. Jing Lu^#, Jingyan Li^#, Yuehuai Hu, Zhen Guo, Dayue Darrel Duan, Duanping Sun, Panxia Wang, Kaiteng Guo, Si Gao, Jianmin Jiang, Junjian Wang*, Peiqing Liu*, Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation, Acta Pharmaceutica Sinica B, 2019, 9: 782-793.?
8. Duanping Sun*, Zibin Luo, Jing Lu*, Shangshi Zhang, Tong Che, Zuanguang Chen, Luyong Zhang*, Electrochemical dual-aptamer-based biosensor for nonenzymatic detection of cardiac troponin I by nanohybrid electrocatalysts labeling combined with DNA nanotetrahedron structure, Biosensors & Bioelectronics, 2019, 134: 49-56.?
9. Duanping Sun*, Xiangan Lin, Jing Lu*, Ping Wei, Zibin Luo, Xiange Lu, Zuanguang Chen, Luyong Zhang*, DNA nanotetrahedron-assisted electrochemical aptasensor for cardiac troponin I detection based on the co-catalysis of hybrid nanozyme, nature enzyme and DNAzyme, Biosensors & Bioelectronics, 2019, 142: 111578.?
10. Jingyan Li^#, Junying Huang^#, Jing Lu^#, Zhen Guo, Zhuoming Li, Hui Gao, Panxia Wang, Wenwei Luo, Sidong Cai, Yuehuai Hu, Kaiteng Guo, Luping Wang, Zhenzhen Li, Minghui Wang, Xiaolei Zhang*, Peiqing Liu*, Sirtuin 1 represses PKC-zeta activity via regulating interplay of acetylation and phosphorylation in cardiac hypertrophy, British Journal of Pharmacology, 2019, 176: 416-435.?
11. Duanping Sun^#,*, Jing Lu^#, Luyong Zhang, Zuanguang Chen, Aptamer-based electrochemical cytosensor for tumor cell detection in cancer diagnosis: A review, Analytica Chimica Acta, 2019, 1082: 1-17.?
12. Qian Li, Zhuoming Li, Shuya Sun, Luping Wang, Panxia Wang, Zhen Guo, Hanwei Yang, Jiantao Ye, Jing Lu*, Peiqing Liu*, PARP1 interacts with HMGB1 and promotes its nucleus export in pathological myocardial hypertrophy, Acta Pharmacologica Sinica, 2019, 40: 589-598.?
13. Yuehuai Hu^#, Zhen Guo^#, Jing Lu*, Panxia Wang, Shuya Sun, Yiqiang Zhang, Jingyan Li, Qiyao Zheng, Kaiteng Guo, Junjian Wang, Jianmin Jiang*, Peiqing Liu*, sFRP1 has a biphasic effect on doxorubicin-induced cardiotoxicity in a cellular location-dependent manner in NRCMs and Rats, Archives of Toxicology, 2019, 93: 533-546.?
14. Panxia Wang, Luping Wang, Jing Lu*, Yuehuai Hu, Qianqian Wang, Zhenzhen Li, Sidong Cai, Liying Liang, Kaiteng Guo, Jiyan Xie, Junjian Wang, Rui Lan, Juan Shen*, Peiqing Liu*, SESN2 protects against doxorubicin-induced cardiomyopathy via rescuing mitophagy and improving mitochondrial function, Journal of Molecular and Cellular Cardiology, 2019, 133: 125-137.?
15. Liying Liang, Yalin Tu, Jing Lu*, Panxia Wang, Zhen Guo, Qianqian Wang, Kaiteng Guo, Rui Lan, Hong Li, Peiqing Liu*, Dkk1 exacerbates doxorubicin-induced cardiotoxicity by inhibiting Wnt/β-catenin signaling pathway, Journal of Cell Science, 2019, 132: jcs228478.?
16. Shuya Sun, Yuehuai Hu, Qiyao Zheng, Zhen Guo, Duanping Sun, Shaorui Chen, Yiqiang Zhang, Peiqing Liu, Jing Lu*, Jianmin Jiang*, PARP1 induces cardiac fibrosis by mediating mTOR activity, Journal of Cellular Biochemistry, 2019, 120: 4813-4826.?
2018年

17. Duanping Sun^#, Jing Lu^#, Zhaofan Luo, Luyong Zhang, Peiqing Liu*, Zuanguang Chen*, Competitive electrochemical platform for ultrasensitive cytosensing of liver cancer cells by using nanotetrahedra probe with rolling circle amplification strategy, Biosensors & Bioelectronics, 2018, 120:8-14.
18. Duanping Sun^#, Jing Lu^#, Dabin Chen^#, Yunfei Jiang, Zhiru Wang, Weiwei Qin, Yanyan Yu, Zuanguang Chen*, Yuanqing Zhang*, Label-free electrochemical detection of HepG2 tumor cells with a self-assembled DNA nanostructure-based aptasensor, Sensors and Actuators B-Chemical, 2018, 268: 359-367.?
19. Luping Wang, Zhuoming Li, Yinzi Tan, Qian Li, Hanwei Yang, Panxia Wang, Jing Lu*, Peiqing Liu*, PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy, Molecular and Cellular Endocrinology, 2018, 474: 137-150.?
2017年之前

20. Duanping Sun^#, Jing Lu^#, Xiangyan Wang, Yuanqing Zhang*, Zuanguang Chen*, Voltammetric aptamer based detection of HepG2 tumor cells by using an indium tin oxide electrode array and multifunctional nanoprobes, Microchimica Acta, 2017, 184: 3487-3496.?
21. Jing Lu, Renwei Zhang, Huiqi Hong, Zuolong Yang, Duanping Sun, Shuya Sun, Xiaolei Guo, Jiantao Ye, Zhuoming Li*, Peiqing Liu*, The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy, Biochimica Et Biophysica Acta-Molecular Cell Research, 2016, 1863: 3027-3039.?
22. Jing Lu, Duanping Sun, Zhiping Liu, Min Li, Huiqi Hong, Cui Liu, Si Gao, Hong Li, Yi Cai, Shaorui Chen, Zhuoming Li, Jiantao Ye*, Peiqing Liu*, SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy, Translational Research, 2016, 172: 96-112.?
参编教材

1.《实验药理学》第二十一章“心血管系统疾病的实验药理学研究”，高等教育出版社，2021年3月出版，参编
2.《高等药理学》第三十章“心力衰竭治疗药物”，科学出版社，2019年7月出版，参编
3.《心脑血管药理学》第十七章“治疗心力衰竭的药物”，科学出版社，2019年3月出版，参编