联系方式
办公电话：
电子邮箱：limin65@mail.sysu.edu.cn
办公地址：药学院
简单介绍
李民，中山大学“****二期”副教授，博士生导师。2007年博士毕业，2007-2012匹兹堡大学和印第安纳大学博士后和研究助理教授。目前专业从事药理学教学和科研工作，主要开展分子药理研究、细胞自噬机制及其调控疾病的机理研究。主持国家自然科学基金面上项目、广东省自然科学基金等各类科研项目多项。以第一/通讯作者在重要学术期刊Autophagy,?Chemical Science.,?Cell Death and Disease，APSB,?JBC等发表论文多篇。申请专利5项，授权2项。目前为广东省成药性评估与评价工程实验室副主任、广东省药理学会药物筛选与评价专委会常务委员、药物毒理专委会委员。
教学情况
药理学
药理学实验（课程负责人）
药理学进展
药物筛选技术与进展
社会/学术任职
广东省药理学会新药筛选与评价专业委员会，常务委员
广东省成药性评估与评价工程实验室，副主任
科研项目
国自然面上项目（2017-2020, 2020-2023）
省自然项目 （2013, 2016, 2019, 2021）
教育部留学回国人员启动基金 2013
教育部博士点新教师基金 2013
****项目启动基金 2013
论著专利 （2010年后）
第一/通讯文章
[21] F. Xia, P. Liu*, M. Li*, The regulatory factors and pathological roles of autophagy‐related protein 4 in diverse diseases: Recent research advances, Medicinal Research Reviews, 2021, 41:1644-1675.
[20] G.?Li#, M.?Zhao#, J.?Xie#, Y.?Yao, L.?Mou, X.?Zhang, X.?Guo, W.?Sun, Z.?Wang, J.?Xu, T.?Hu, M.?Zhang, M.?Li*, L.?Hong*, Efficient synthesis of cyclic amidine-based fluorophores via 6p-electrocyclic ring closure, Chemical Science, 2020,?11: 3586-3591.
[19] Y. Fu#, Q. Gu#, L. Luo#, J.?Xu, Y. Luo, F. Xia, F. Han, L. Hong, X.M. Yin, Z. Huang*, M. Li*,? New anti-cancer strategy to suppress colorectal cancer growth through inhibition of ATG4B and lysosome function, Cancers, 2020, 12:?e1523.?
[18] X. Zheng#, Z. Yang#, Q. Gu, F. Xia, Y. Fu, P. Liu, X.M. Yin, M. Li*,??The protease activity of human?ATG4B?is regulated by reversible oxidative modification, Autophagy, 2020, 16:?1838-1850.?
[17] Q. Dai, Z. Zheng, F. Xia, P. Liu*,?M. Li*,?A one-step specific assay for continuous detection of sirtuin 2 activity,?Acta Pharmaceutica Sinica. B, 2019, 9:?1183-1192.
[16] Y. Fu#, Z. Huang#, L.?Hong, J.H. Lu, D. Feng, X.M. Yin*, M. Li*,?Targeting ATG4 in Cancer Therapy, Cancers, 2019, 11:?e649.?
[15] H. Shan#, X. Zheng#, M. Li*,?The effects of Astragalus membranaceus active extracts on autophagy-related diseases,?Int. J. Mol. Sci., 2019, 20:?e1904.?
[14] Y. Liu#, X. Luo#, H. Shan#, Q. Gu, X. Zheng, Q. Dai, F. Xia, Z. Zheng, P. Liu, X. M. Yin, L. Hong*, M. Li*, Niclosamide triggers non-canonical LC3 lipidation, Cells, 2019, 8:?e248.
[13] Y. Fu#, L. Hong#, J. Xu#, G. Zhong#, Q. Gu, Q. Gu, Y. Guan, X. Zheng, Q. Dai, X. Luo, C. Liu, Z. Huang, X.M. Yin, P. Liu*, M. Li*, Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo, Autophagy, 2019, 15:?295-311.
[12] W. Wen#, J. Chen#, L. Ding, X. Luo, X. Zheng, Q. Dai, Q. Gu, C. Liu, M. Liang, X. Guo, P. Liu*, M. Li*, Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy, Arch Biochem Biophys, 2018, 657:?31-40.
[11] J. Chu#, Y. Fu#, J. Xu#, X. Zheng, Q. Gu, X. Luo, Q. Dai, S. Zhang, P. Liu, L. Hong*, M. Li*, ATG4B inhibitor FMK-9a induces autophagy independent on its enzyme inhibition, Arch Biochem Biophys, 2018, 644:?29-36.
[10] S.T. Li, Q. Dai, S.X. Zhang, Y.J. Liu, Q.Q. Yu, F. Tan, S.H. Lu, Q. Wang, J.W. Chen, H.Q. Huang, P.Q. Liu*, M. Li*, Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-kappaB signaling pathway and activating the PI3K/Akt/Nrf2 pathway, Acta Pharmacol Sin, 2018, 39:?1294-1304.
[9] M. Li*, Y. Fu, Z. Yang, X.M. Yin*, Measurement of the activity of the Atg4 cysteine proteases, Methods Enzymol, 2017, 587:?207-225.
[8] Y. Gao#, Y. Liu#, L. Hong, Z. Yang, X. Cai, X. Chen, Y. Fu, Y. Lin, W. Wen, S. Li, X. Liu, H. Huang, A. Vogt, P. Liu*, X.M. Yin*, M. Li*, Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy, Cell Death Dis, 2016, 7:?e2330.
[7] M. Zhang, W.S. Sun, G.M. Zhu, G.J. Bao, B.Z. Zhang, L. Hong*, M. Li*, R. Wang*, Enantioselective dearomative arylation of isoquinolines, ACS Catal, 2016, 6:?5290-5294.
[6] J. Zhou, Z. Yang, F. Zhang, H.B. Luo, M. Li*, R. Wu*, A salt bridge turns off the foot-pocket in class-II HDACs, Phys Chem Chem Phys, 2016, 18:?21246-21250.
[5] M. Li*, Z. Yang, L.L. Vollmer, Y. Gao, Y. Fu, C. Liu, X. Chen, P. Liu, A. Vogt, X.M. Yin*, AMDE-1 is a dual function chemical for autophagy activation and inhibition, PLoS One, 2015, 10:?e**.
[4] S. Gao, H. Li, Y. Cai, J.T. Ye, Z.P. Liu, J. Lu, X.Y. Huang, X.J. Feng, H. Gao, S.R. Chen, M. Li*, P.Q. Liu*, Mitochondrial binding of alpha-enolase stabilizes mitochondrial membrane: its role in doxorubicin-induced cardiomyocyte apoptosis, Arch Biochem Biophys, 2014, 542:?46-55.
[3] M. Li, B. Khambu, H. Zhang, J.H. Kang, X. Chen, D. Chen, L. Vollmer, P.Q. Liu, A. Vogt, X.M. Yin*, Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity, J Biol Chem, 2013, 288:?35769-35780.
[2] M. Li, X. Chen, Q.Z. Ye, A. Vogt, X.M. Yin*, A high-throughput FRET-based assay for determination of Atg4 activity, Autophagy, 2012, 8:?401-412.
[1] M. Li, Y.F. Hou, J.S. Wang, X.Y. Chen, Z.M. Shao, X.M. Yin*, Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates, J Biol Chem, 2011, 286:?7327-7338.
?
其他
本课题组招收特聘研究员、副研究员及博士后人员，欢迎对自噬发生机制、自噬在疾病调控中的作用、细胞器等方向感兴趣。直接联系本人。
欢迎研究生报考！
?