联系方式
办公电话：(O)
电子邮箱：lsshhy@mail.sysu.edu.cn
办公地址：广州市大学城外环东路132号 中山大学药学院214B室 邮编：510006
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简单介绍
胡海燕，女，博士，教授，博士生导师。从事新药研发及新型给药系统的研究。主持和完成多个新药研发项目，作为主要负责人参与研发的1.1类化学药安脑三醇注射剂已获临床批件，目前已经完成I期临床试验。主要研究方向：1)菌膜靶向递药系统；2）肿瘤靶向递药系统；3)经皮递药系统。在J Control Release、Carbohyd Polym、ACS Appl Mater Interfaces、Mol Pharmaceut、Int J Pharm上共发表学术论文30余篇，并获得10余项中国专利授权，其中两项获得包括美国、日本在内的多国专利授权。主持国家自然科学基金、 “十二五”国家科技重大专项“重大新药创制”、广东省自然科学基金等多项国家及省部级课题。《药学学报》青年编委, 中国药学会药剂学专委会委员，中国民族医药学会布朗医药分会常务理事。
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研究方向
1)菌膜靶向递药系统；2）肿瘤靶向递药系统；3)经皮递药系统
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教育经历
2014/11-2015/11 英国诺丁汉大学，访问****
2008/05-2008/08 美国Huahai US Co., Ltd.，Senior Research Fellow
2003/09-2006/06 四川大学，获得药剂学博士学位；
1995/09-1998/06 华西医科大学（现四川大学），获得药剂学硕士学位
1991/09-1995/06 华西医科大学（现四川大学），获得药学学士学位
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工作经历
2017/1至今 中山大学药学院教授
2016/4-2017/4 滇西应用技术大学傣医药学院副院长(挂职)
2010/1-2017/1 中山大学药学院副教授
1998/7-2010/1 中山大学药学院（系）助教、讲师
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教学情况
本科生课程 药剂学实验（课程负责人）、 药剂学
研究生课程 药剂学进展（课程负责人）、药物给药系统设计及其分子学基础
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社会/学术任职
《药学学报》青年编委
中国药学会药剂学专委会委员
中国民族医药学会布朗医药分会常务理事
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科研项目
[1]?国家自然科学基金面上项目：针对铜绿假单胞菌菌膜所致顽固性肺部感染的全过程智能递药系统的构建及其阻断细菌耐药发生的机制研究（课题负责人，No. **，2020～2023年）
[2] 国家自然科学基金面上项目：仿病毒亲水富电表面介孔二氧化硅纳米粒的构建及其克服胰岛素口服吸收多重屏障的机制研究（课题负责人，No. **，2018～2021年）
[3] 国家自然科学基金面上项目：靶向降解、清除幽门螺杆菌菌膜 (biofilm)的多功能脂质-聚合物杂化纳米粒的制备、作用评价及相关机制研究（课题负责人，No. **，2015～2018年）
[4] 国家自然科学基金面上项目：胆固醇代谢产物Triol作为内源性神经保护因子的发现及其作用机制研究”（课题负责人，No. **，2012～2015年，）
[5] “十二五”国家科技重大专项“重大新药创制”：针对欧洲市场阿奇霉素制剂的研发与产业化（课题负责人，No. 2011ZX09202-101-06 ，2011～2014年）
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代表性论著
Yi Zhang, Mengting Xiong, Xiaomin Ni, Jingrou Wang, Hehui Rong, Yuqing Su, Shihui Yu, Imran Shair Mohammad, Sharon Shui Yee Leung, Haiyan Hu*(通讯作者). Virus-Mimicking Mesoporous Silica Nanoparticles with an Electrically Neutral and Hydrophilic Surface to Improve the Oral Absorption of Insulin by Breaking Through Dual Barriers of the Mucus Layer and the Intestinal Epithelium. ACS Appl Mater Interfaces, 2021,?https://doi/10.1021/acsami.1c00580
Chuchu Lin, Xuan Yang, Huatian Li, Yiqing Zou, Imran Shair Mohammad, Hehui Rong, Yiqin Rao, Jia Song, Sharon Shui Yee Leung, Haiyan Hu*(通讯作者). Self-assembled nanomedicine combining a berberine derivative and doxorubicin for enhanced antitumor and antimetastatic efficacy via mitochondrial pathways dagger. Nanoscale, 2021, 13, 6605.
Yuanna Shen, Zou Yiqing, Xiaonan Chen, Pengyu Li, Yiqin Rao, Xuan Yang, Yingying Sun, Haiyan Hu*(通讯作者). Antibacterial self-assembled nanodrugs composed of berberine derivatives and rhamnolipids against Helicobacter pylori. J Control Release, 2020, 328, 575-586.
Xiaomin Ni, Qin Guo, Yiqing Zou, Xuan Yang, Imran Shair Mohammad, Qing Ding, Haiyan Hu*(通讯作者).?Preparation and characterization of bear bile-loaded pH sensitive in-situ gel eye drops for ocular drug delivery.?Iran J Basic Med Sci,?2020, 23(7): 922-929.
Yuanna Shen, Pengyu Li, Xiaonan Chen, Yiqing Zou, Huatian Li, Gang Yuan, Haiyan Hu*?(通讯作者). Activity of Sodium Lauryl Sulfate, Rhamnolipids, and N-Acetylcysteine Against Biofilms of Five Common Pathogens.??Microbial Drug Resistance, 2020, 26 (3): 290-299.
Chong Li, Jiancheng Wang*, Yiguang Wang, Huile Gao, Gang Wei, Yongzhuo Huang,?Haijun Yu, Yong Gan, Yongjun Wang, Lin Mei, Huabing Chen, Haiyan Hu（共同第一）, Zhiping Zhang, Yiguang Jin.?Recent progress in drug delivery.??Acta Pharmaceutica Sinica B, 2019, 9(6):1145-1162.
Xuewen Li, Meixiang Huang, Kakei Lo, Weili Chen, Yingyan He, Yongli Xu, Huizhen Zheng, Haiyan Hu*（共同通讯）, Jun Wang*. Anti-Diabetic Effect of a Shihunine-Rich Extract of Dendrobium loddigesii on 3T3-L1 Cells and db/db Mice by Up-Regulating AMPK–GLUT4–PPARα. Molecules, 2019, 24, 2673.?
Xiaonan Chen, Pengyu Li,?Yuanna Shen, Yiqing Zou, Gang Yuan*, Haiyan Hu*（共同通讯）.?Rhamnolipid-involved antibiotics combinations improve the eradication of Helicobacter pylori biofilm in vitro: A comparison with conventional triple therapy.?Microbial Pathogenesis, 2019, 131, 112-119.
Pengyu Li, Xiaonan Chen, Yuanna Shen, Yiqing Zou, Gang Yuan, Ping Hu, Haiyan Hu*（通讯作者）. Mucus penetration enhanced lipid polymer nanoparticles improve the eradication rate of Helicobacter pylori biofilm. J Control Release, 2019, 300: 52-63. ?
Jia Song, Chuchu Lin, Xuan Yang, Yanqi Xie, Ping Hu, Huatian Li, Wenbo Zhu, Haiyan Hu*（通讯作者）. Mitochondrial targeting nanodrugs self-assembled from 9-O-octadecyl substituted berberine derivative for cancer treatment by inducing mitochondrial apoptosis pathways. J Control Release, 2019, 294:27-42.
Yalong Wang, Huizhi Huang, Haijuan Zou, Xuyan Tian, Jun Hu, Pengxin Qiu, Haiyan Hu*（通讯作者）, Guangmei Yan. Liposome Encapsulation of Oncolytic Virus M1 To Reduce Immunogenicity and Immune Clearance in Vivo. Mol Pharm, 2019, 16(2):779-785.
Xuewen Li, Huiping Chen, Yingyan He, Weili Chen, Jianwen Chen, Lu Gao, Haiyan Hu*（共同通讯）, Jun Wang*. Effects of Rich-Polyphenols Extract of Dendrobium loddigesii on Anti-Diabetic, Anti-Inflammatory, Anti-Oxidant, and Gut Microbiota Modulation in db/db Mice. Molecules, 2018, 23(12), 3245.
Huiping Chen, Xuewen Li, Yongli Xu, Kakei Lo, Huizhen Zheng, Haiyan Hu*（共同通讯）, Wang Jun*, Lin Yongcheng. Study on the Polar Extracts of Dendrobium nobile, D. officinale, D. loddigesii, and Flickingeria fimbriata: Metabolite Identification, Content Evaluation, and Bioactivity Assay. Molecules, 2018, 23(5), 1185.
Huanbin Zhou, Jiashu Chen, Shunyi Li, Jianpan Zhang, ChunE Zhu, Hao Ran, Meihua Luo, Xin Pan*, Haiyan Hu*（共同通讯）, Chuanbin Wu. Preparation of Acid‐Resistant Microcapsules with Shell‐Matrix Structure to Enhance Stability of Streptococcus Thermophilus IFFI 6038. J Food Sci, 2017, 82(8):1978-1984.
Qin Guo, Jie Cai, Pengyu Li, Dongling Xu, Xiaomin Ni, Hui Wen, Dan Liu, LIN Suizhen , HU Haiyan*（通讯作者）. Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability. Drug Design, Dev &Therapy, 2016, 10: 3789–3798.
Jue Tuo, Yanqi Xie, Jia Song, Yizhen Chen, Qin Guo, Xin Liu, Xiaomin Ni, Dongling Xu, Huizhi Huang, Sheng Yin, Wenbo Zhu, Jun Wu, Haiyan Hu*（通讯作者）. Development of a novel berberine-mediated mitochondria-targeting nano-platform for drug-resistant cancer therapy. J Material Chem B, 2016, 4: 6856-64.
Pengyu Li, Jia Song, Xiaomin Ni, Qin Guo, Hui Wen, Qiuyun Zhou, Yuanna Shen, Yijun Huang, Pengxin Qiu, Suizhen Lin, Haiyan Hu*（通讯作者）. Comparison in toxicity and solubilizing capacity of hydroxypropyl-β-cyclodextrin with different degree of substitution. Int J Pharmaceut, 2016,513: 347-356.
Qiao Xing, Jia Song, Xiuhua You, Dongling Xu, Kexin Wang, Jiaqi Song, Qin Guo, Pengyu Li, Chuanbin Wu, Haiyan Hu*（通讯作者）. Microemulsions containing long-chain oil ethyl oleate improve the oral bioavailability of piroxicam by increasing drug solubility and lymphatic transportation simultaneously. Int J Pharmaceut, 2016, 511: 709-7
Youqiong Wang, Lipeng Tang, Wei Yin, Jiesi Chen, Tiandong Leng, Xiaoke Zheng, Wenbo Zhu, Haipeng Zhang, Pengxin Qiu, Xiaoxiao Yang, Guangmei Yan, Haiyan Hu*（通讯作者）. Simultaneous Determination of Seven Neuroactive Steroids Associated with Depression in Rat Plasma and Brain by High Performance Liquid Chromatography–Tandem Mass Spectrometry. Anal Sci, 2016, 32(9):981-988.
Jie Cai, huizhi Huang, Weijuan Song, Haiyan Hu*（通讯作者）, Jiesi Chen, Liyan Zhang, Pengyu Li, Rui Wu, Chuanbin Wu. Preparation and evaluation of lipid polymer nanoparticles for eradicating H. pylori biofilm and impairing antibacterial resistance in vitro. Int J Pharmaceut, 2015, 495 (2): 728-737.
Yizhen Chen, Jue Tuo, Huizhi Huang, Dan Liu, Xiuhua You, Jialuo Mai, Jiaqi Song, Yanqi Xie, Chuanbin Wu, Haiyan Hu*（通讯作者）. Optimized mixed oils remarkably reduce the amount of surfactants in microemulsions without affecting oral bioavailability of ibuprofen by simultaneously enlarging microemulsion areas and enhancing drug solubility. Int J Pharmaceut, 2015, 487(1-2):17-24.
Lipeng Tang, Youqiong Wang, Tiandong Leng, Huanhuan Sun, Yuehan Zhou, Wenbo Zhu, Pengxin Qiu, Jingxia Zhang, Bingzheng Lu, Min Yan, Wenli Chen, Xinwen Su, Wei Yin, Yijun Huang, Haiyan Hu* (共同通讯), YAN Guangmei*. Cholesterol metabolite cholestane-3β,5α,6β-triol suppresses epileptic seizures by negative modulation of voltage-gated sodium channels. Steroids, 2015, 98:166-72.
Yalong Wang, Han Jiang, Huizhi Huang, Yanqi Xie, Yunsi Zhao, Xiuhua You, Lipeng Tang, Youqiong Wang, Wei Yin, Pengxin Qiu, Guangmei Yan, Haiyan Hu*（通讯作者）. Determination of neuroprotective oxysterols in Calculus bovis, human gallstones, and traditional Chinese medicine preparations by liquid chromatography with mass spectrometry. J Sep Sci, 2015,38(5):796-803.
Shengnan Fu, Yanqi Xie, Jue Tuo, Yalong Wang, Wenbo Zhu, Sihan Wu, Guangmei Yan, Haiyan Hu*（通讯作者）. Discovery of mitochondria-targeting berberine derivatives as the inhibitors of proliferation, invasion and migration against rat C6 and human U87 glioma cells. MEDCHEMCOMM, 2015. 6(1), 164-173.
Meihong Huang, Jiaqi Song, Bingzheng Lu, Huizhi Huang, Yizhen Chen, Wei Yin, Wenbo Zhu, Xinwen Su, Chuanbin Wu, Haiyan Hu*(通讯作者). Synthesis of taurine–fluorescein conjugate and evaluation of its retina-targeted efficiency in vitro. Acta Pharmaceutica Sinica B, 2014, 4, 447-453.
Yuan Li, Jiaqi Song, Ning Tian, Jie Cai, Meihong Huang, Qiao Xing, Yalong Wang, Chuanbin Wu, Haiyan Hu*（通讯作者）. Improving oral bioavailability of metformin hydrochloride using water-in-oil microemulsions and analysis of phase behavior after dilution. Int J Pharmaceut, 2014, 473: 316–325.
Haiyan Hu(第一作者), Yuehan Zhou, Tiandong Leng, Ailing Liu, Youqiong Wang, Xiuhua You, Jiesi Chen, Lipeng Tang, Wenli Chen, Pengxin Qiu, Wei Yin, Yijun Huang, Jingxia Zhang, Liwei Wang, Hanfei Sang * and Guangmei Yan *. The major cholesterol metabolite cholestane-3β,5α,6β-triol functions as an endogenous neuroprotectant. J Neurosci, 2014,34(34):11426-38.
Xiuhua You, Qiao Xing, Jue Tuo, Weijuan Song, Ying Zeng* and Haiyan Hu*（通讯作者）.Optimizing surfactant content to improve oral bioavailability of ibuprofen in microemulsions: just enough or more than enough? Int J Pharmaceut. 2014, 471(1-2):276-84.
Ling Li, Jue Tuo , Yanqi Xie, Meihong Huang, Min Huang, Rongbiao Pi, Haiyan Hu*（通讯作者）. Preparation, transportation mechanisms and brain-targeting evaluation in vivo of a chemical delivery system exploiting the blood-cerebrospinal fluid barrier. J Drug Target, 2014, 22(8):724-31.
Weijuan Song, Yalong Wang, Liyan Zhang, Shengnan Fu, Ying Zeng and Haiyan Hu*（通讯作者）.? Preparation and evaluation of polysaccharide sulfates for inhibiting Helicobacter pylori adhesion. Carbohyd Polym, 2014,103:398-404.
Sijia Zheng, Yanqi Xie, Yan Li, Ling Li, Ning Tian, Wenbo Zhu, Guangmei Yan, Chuanbin Wu, Haiyan Hu *(通讯作者). Development of high drug-loading nanomicelles targeting steroids to the brain, Int J Nanomed, 2014, 9: 55-66.
Yanqiu Ou, Xiaoke Zheng, Yixing Gao, Minfeng Shu, Tiandong Leng, Yinwei Li, Wenbo Zhu, Yijun Huang, Yuxi Zhou, Jianjun Tang, Pengxin Qiu, Guangmei Yan, Jun Hu, Huaizhen Ruan *, Haiyan Hu*（共同通讯）. Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics, UROL ONCOL-SEMIN ORI, 2014, 47, e21-e28.
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发明专利
[1] 胡海燕，庹珏，王亚龙，谢彦奇，付胜楠，颜光美，银巍. 小檗碱衍生物及其用途. 中国发明专利，专利号ZL6.7，授权日期 2016.8.10。
[2] 胡海燕，付胜楠, 庹珏，谢彦奇，张国光，王亚龙，朱文博. 小檗碱衍生物的医药用途. 中国发明专利，专利号ZL4.0，授权日期 2016.8.31。
[3] 胡海燕，宋玮娟，付胜楠，曾颖. 聚半乳糖醛酸硫酸酯在制备抗幽门螺旋杆菌药物中的应用. 专利号ZL7.7，专利申请日2012年12月23日，发明专利，授权日期 2014.10.1
[4] 胡海燕，蔡婕，王亚龙，王亚娜，林穗珍，石海涛. 5α-雄甾-3β,5,6β-三醇注射剂及其制备方法, 发明专利。中国专利号ZL 2013 1 **.X，授权日期2015.3.26
[5] 颜光美，胡海燕，冷田东，桑韩飞，张静夏，邱鹏新，周树佳，陈婕思，游秀华. 5α-雄甾(烷)-3β,5,6β-三醇在制备神经元保护药物中的应用，发明专利。 中国（专利号ZL3.3，授权日期2011.8.24）, 美国（专利号8,809,309，授权日期2014.8.19）新加坡（专利号-8，授权日期2014.2.14），加拿大（专利号2,802,133，授权日期2014. 1.14），澳大利亚（专利号2,011,276,800，授权日期2014.3.8），日本（专利号**，授权日期2015.1.23），韩国（专利号10‐**，授权日期2014.11.13），俄罗斯（专利号**，授权日期2014.12.24）.
[6] 颜光美，胡海燕，张静夏，邱鹏新，李玲，田宁. 一种5α-雄甾(烷)-3β,5,6β-三醇注射剂及其制备方法，发明专利。 中国(专利号ZL4.X，授权日期2012.11.21), 澳大利亚（专利号，授权日期2015.2.5），日本（专利号**，授权日期2015.5.29），韩国（专利号，授权日期2014.11.25），俄罗斯（专利号**，授权日期2014.9.5）。
[7] 颜光美，胡海燕，孙环环，桑韩飞，冷田东，刘爱伶，银巍，黄奕俊，张静夏，邱鹏新。胆甾烷-3β,5α,6β-三醇在制备神经元保护药物中的应用. 中国发明专利，专利号ZL3.4，授权日期 2012.7.4.
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