简介
黄艳娟，1993年6月生，理学博士，博士后。2020年获中山大学药剂学博士学位，主要从事新型靶向递药系统的设计与评价。在国内外重要学术刊物，包括J Control Release、Chem Eng J、Acta Pharm Sin B、Int J Pharm、Nanoscale、Theranostics、J Mater Chem B、Asian J Pharm Sci、Eur J Med Chem等发表学术论文17篇，其中第一作者论文6篇（两篇为本领域顶级期刊）。主持第68批博士后面上项目，广东省自然科学基金-面上项目1项，广东省基础与应用基础研究联合基金-青年基金项目1项，参与3项国家自然科学基金等国家级课题。曾获国家奖学金，中山大学优秀博士论文（全院仅两篇，全校37篇）。曾获广东省优秀学生和中山大学优秀博士毕业生等荣誉称号。
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科研项目
1、工程化M1型巨噬细胞的构建及其双重抑制乳腺癌及骨转移的研究 中国博士后科学基金第68批面上项目，负责人，2021-2024.
2、人工工程化活细胞治疗制剂的构建及其用于乳腺癌骨转移的研究，广东省自然科学基金-面上项目，负责人，2021-2024.
3、智能响应骨靶向递药载体用于抗骨转移、抑骨溶蚀及促骨修复三重作用机制的研究，广东省基础与应用基础研究联合 基金-青年基金，负责人，2020-2023.
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发表论文
[1] Y. Huang#, Z. Xiao#, Z. Guan, Y. Shen, Y. Jiang, X. Xu, Z. Huang, C. Zhao*, A light-triggered self-reinforced nanoagent for targeted chemo-photodynamic therapy of breast cancer bone metastases via ER stress and mitochondria mediated apoptotic pathways, Journal of Controlled Release?319 (2020) 119-134.
[2] Y. Huang#, Y. Jiang#, Z. Xiao#, Y. Shen, L. Huang, X. Xu, G. Wei, C. Xu, C. Zhao*, Three birds with one stone: A ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/chemodynamic therapy with glutathione depletion, Chemical Engineering Journal?380 (2020) 122369.
[3] Y. Huang#, Y. He#, Z. Huang, Y. Jiang, W. Chu, X. Sun, L. Huang, C. Zhao, Coordination self-assembly of platinum–bisphosphonate polymer–metal complex nanoparticles for cisplatin delivery and effective cancer therapy, Nanoscale?9(28) (2017) 10002-10019.
[4] Y. Huang, Z. Xiao, Z. Guan, Z. Zeng, Y. Shen, X. Xu, C. Zhao, Bone-seeking nanoplatform co-delivering cisplatin and zoledronate for synergistic therapy of breast cancer bone metastasis and bone resorption, Acta Pharmaceutica Sinica B (2020).
[5] Y. He#,?Y. Huang#?(共一), Z. Huang, Y. Jiang, X. Sun, Y. Shen, W. Chu, C. Zhao, Bisphosphonate-functionalized coordination polymer nanoparticles for the treatment of bone metastatic breast cancer, Journal of Controlled Release?264 (2017) 76-88.
[6] W. Chu#, Y. Huang# (共一), C. Yang, Y. Liao, X. Zhang, M. Yan, S. Cui, C. Zhao, Calcium phosphate nanoparticles functionalized with alendronate-conjugated polyethylene glycol (PEG) for the treatment of bone metastasis, International journal of pharmaceutics?516(1-2) (2017) 352-363.
[7] Z. Huang, Y. Huang, M. Chen, J. Chen, Z. Zeng, X. Xu, B. Huang, Y. Luo, Z. Xiao, Y. Ding, Bone-targeted oxidative stress nanoamplifier for synergetic chemo/chemodynamic therapy of bone metastases through increasing generation and reducing elimination of ROS, Chemical Engineering Journal??(2020) 125667.
[8] Z. Huang, L. Huang, Y. Huang, Y. He, X. Sun, X. Fu, X. Xu, G. Wei, D. Chen, C. Zhao, Phthalocyanine-based coordination polymer nanoparticles for enhanced photodynamic therapy, Nanoscale?9(41) (2017) 15883-15894.
[9] Z. Huang, G. Wei, Z. Zeng, Y. Huang, L. Huang, Y. Shen, X. Sun, C. Xu, C. Zhao, Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor, Theranostics?9(19) (2019) 5542.
[10] Y. Liao, X. Zhang, C. Li, Y. Huang, M. Lei, M. Yan, Y. Zhou, C. Zhao, Inclusion complexes of HP-β-cyclodextrin with agomelatine: preparation, characterization, mechanism study and in vivo evaluation, Carbohydrate polymers?147 (2016) 415-425.
[11] X. Xu, Z. Zeng, Z. Huang, Y. Sun, Y. Huang, J. Chen, J. Ye, H. Yang, C. Yang, C. Zhao, Near-infrared light-triggered degradable hyaluronic acid hydrogel for on-demand drug release and combined chemo-photodynamic therapy, Carbohydrate Polymers?229 (2020) 115394.
[12] X. Sun, D. Liu, X. Xu, Y. Shen, Y. Huang, Z. Zeng, M. Xia, C. Zhao, NIR-triggered Thermo-Responsive Biodegradable Hydrogel with Combination of Photothermal and Thermodynamic Therapy for Hypoxic Tumor, Asian Journal of Pharmaceutical Sciences??(2020).
[13] X. Zhang, B. Huang, Y. Shen, C. Yang, Z. Huang,?Y. Huang, X. Xu, Y. Jiang, X. Sun, X. Li, Near infrared light triggered reactive oxygen species responsive nanoparticles for chemo-photodynamic combined therapy, Journal of Materials Chemistry B?6(15) (2018) 2347-2357.
[14] L. Huang, G. Wei, X. Sun, Y. Jiang, Z. Huang, Y. Huang, Y. Shen, X. Xu, Y. Liao, C. Zhao, A tumor-targeted Ganetespib-zinc phthalocyanine conjugate for synergistic chemo-photodynamic therapy, European journal of medicinal chemistry?151 (2018) 294-303.
[15] X. Xu, Z. Zeng, J. Chen, B. Huang, Z. Guan, Y. Huang, Z. Huang, C. Zhao, Tumor-Targeted Supramolecular Catalytic Nanoreactor for Synergistic Chemo/Chemodynamic Therapy via Oxidative Stress Amplification and Cascaded Fenton Reaction, Chemical Engineering Journal??(2020) 124628.
[16] G. Wei, L. Huang, Y. Jiang, Y. Shen, Z. Huang, Y. Huang, X. Sun, C. Zhao, Lenvatinib-zinc phthalocyanine conjugates as potential agents for enhancing synergistic therapy of multidrug-resistant cancer by glutathione depletion, European journal of medicinal chemistry?169 (2019) 53-64.
[17] X. Xu, B. Huang, Z. Zeng, J. Chen, Z. Huang, Z. Guan, M. Chen, Y. Huang, C. Zhao*, Broaden sources and reduce expenditure: Tumor-specific transformable oxidative stress nanoamplifier enabling economized photodynamic therapy for reinforced oxidation therapy, Theranostics 10(23) (2020) 10513.
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