联系方式办公电话：
电子邮箱：zhangge@mail.sysu.edu.cn
办公地址：
简单介绍张革，女，博士，教授，博士生导师。
研究方向肿瘤相关微生物学，疫苗，益生菌制剂的研究。
靶向抗肿瘤药物前体的活性及机制研究。
肿瘤分子标记及早期诊断试剂盒的研究
?教育经历2002--2005年??? 中山大学中山医学院?组织胚胎与解剖学博士学位
1997--2000年?? ?重庆医科大学基础医学院 生物化学和分子生物学专业硕士学位。
1989--1993年??? 西北大学生物系 微生物学学士学位。
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工作经历2003--至今???? ? ?中山大学药学院? 微生物与生化制药实验室 教授 博导
2000--2003年??? 中山大学分子医学中心 分子医学 助理研究员
1993--1997年??? 陕西省人民医院 临床微生物检验 技术员
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教学情况生物技术制药（课程负责人.）
微生物与免疫学（课程负责人）
省级教学基地：中山大学药学院—广州栋方股份公司教学实践基地（项目负责人，2015/5 -2018/5, 20万）
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科研项目主持基金项目如下：
国家自然科学基金面上项目：具核梭杆菌胞内共生致癌促癌机制及胞内菌清除策略的研究（**；2020/1-2023/12, 55万）
国家自然科学基金面上项目：耐具核梭杆菌拮抗的双歧杆菌及其重组活载体防治结直肠癌实验研究；(**；2017/1-2020/12, 58万)
国家自然科学基金面上项目：具核梭杆菌在食管癌发生发展中的作用及其机制的研究。（**；2014/1-2017/12，70万）
国家自然科学基金面上项目：iRGD-GP肽修饰的细胞毒类抗肿瘤靶向药物的研究。（**；2011/1-2013/12，30万）
广东省自然科学基金面上项目：具核梭杆菌胞内感染致上皮细胞恶性化机制研究（No：2019A；2019/10-2022/09，10万）
广东省自然科学基金面上项目：基于菌群变化的结直肠癌早期筛查研究（No：2017A；2018/1-2020/12，10万）
广东市科技计划项目：天然冰片制备过程副产物的回收纯化及其在绿色药妆中的应用研究 (No：5, 2017/1-2018/12, 50万）
广东省科技计划项目：CDC25B等自身抗体反向芯片对食管癌早期诊断的研究。(No：2012B，2012/1-2014/12， 4万）
广东省花都区科技计划项目：基于植物多糖在绿色抗衰老化妆品中的应用研究。(HD15GY018，2015/01-2016/12，9万)
中山大学青年教师培育项目: 靶向FAPa增强DC-CIK免疫治疗效果的实验研究。(2011/1-2014/12，15万）
企业横向基金：.肠道健康微生物诊断试剂盒的研发（2018/10-2021/10, 30万）
企业横向基金：绿色化妆品中生物功效成分的细胞学评价。（2015/3 -2018/8, 12万 ）
企业横向基金：益生菌验证项目。（2015/5 -2017/5，8万）
企业横向基金：.莫昔克丁菌种检测鉴定（2018/10-2021/10）
?论著专利代表性论文：
Guo SH, Chen J, Chen FF, Zeng QY, Liu WL*, Zhang G*. Exosomes derived from Fusobacterium nucleatum infected colorectal cancer cells facilitate tumor metastasis by selectively carrying miR-1246/92b-3p/27a-3p and CXCL16. Gut. ?2020, doi:10.1136/gutjnl-2020-321187
Ganesan K, Guo SH, Fayyaz S, Zhang G* Xu BJ*. Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy. Cancers. 2019, 11:1592
Guo SH, Lu YF, Xu BL, Wang W, Xu JH, Zhang G*. A simple fecal bacterial marker panel for the diagnosis of Crohn’s disease. Front Microbiol 2019, 10: 1306?
Guo SH, Li LF, Xu BL, Li MH, Zeng QY, Xiao H, Xue Y, Wu YX, Wang YD, Liu WL*, Zhang G*. A simple and novel faecal biomarker for colorectal cancer: ratio of Fusobacterium nucleatum to probiotics populations based on their antagonistic effect 2018, 64(9):1327-1337,. Clinical Chemistry.
Liu WL, Li JP, Wu YX, Xing S, Lai YZ, Zhang G*. Target-induced proximity ligation triggers recombinase polymerase amplification and transcription-mediated amplification to detect tumor-derived exosomes in nasopharyngeal carcinoma with high sensitivity. Biosensors & Bioelectronics, 2018, 102:204-210
Feng XW, Lu JF, He ZT, Wang YD, Qi FF, Pi RX, Zhang G*. Mycobacterium smegmatis induces neurite outgrowth and differentiation in an autophagy-independent manner in PC12 and C17.2 cells, Front Cell Infect Mi. 2018, 8:201
Xue Y, XiaoH, Guo S, Xu B, Liao Y, W u Y, Zhang G*.Indoleamine 2,3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages. Cell Death & Disease. 2018, 9(3):355,
Guo SH, Wang HF, Nian ZG, Wang YD, Zeng QY,Zhang G*. Immunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal. Scientific Reports. 2017,?7:10566
Feng XW,?Wang QF, Liao YH, Zhou X, Wang YD, Liu WL,Zhang G*. A synthetic urinary probe coated nanoparticles sensitive to fibroblast activation protein-α for solid tumor diagnosis. Int J Nanomed. 2017,12 :5359-5372
?Liao Y, Xing S, Xu BL, Liu W, Zhang G*. Evaluation of the circulating level of fibroblast activation protein α for diagnosis of esophageal squamous cell carcinoma. Oncotarget. 2017, 8(18):30050-30062
Feng XW, Lin JH, Xing S, Liu WLZhang G*. Higher IGFBP-1 to IGF-1 serum ratio ,unfavourable survival in patients with nasopharyngeal carcinoma. BMC Cancer. 2017,17:90,
Wang HF, Li LF, Guo SH, Zeng QY, Ning F, Liu WLZhang G*. Evaluation of antibody level against ,Fusobacterium nucleatum in the serological diagnosis of colorectal cancer. Sci Rep. 2016, 6:33440
Liu WL, Liu D, Cheng K, Liu YJ, Xing S, Chi PD, Liu XH, Xue N, Lai YZ, Guo LZhang G*. Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer. Oncotarget. 2016, 7(19): 28124-28138,
Wang WF, Ning F, Xue Y, Feng XW, Du J, Zhang G*. iRGD-targeted delivery of a pro-apoptotic peptide activated by cathepsin B inhibits tumor growth and metastasis in mice. Tumor Biol. 2016, 37(8):10643-52
Liao Y, Xue Y, Zhang L, Feng X, Liu W, Zhang G*. ?Higher heat shock factor 1 expression in tumor stroma predicts poor prognosis in esophageal squamous cell carcinoma patients. J Transl Med. 2015,13:338
Liu WL, Lin YH, Xiao H, Xing S, Chen H, Chi PD, Zhang G*.? Epstein-Barr virus iifection induces indoleamine 2,3-Dioxygenase expression in human monocyte-derived macrophages through p38/mitogen-activated protein kinase and NF-κB pathways: impairment in T cell functions. J Virol. 2014, 88(12):6660-6671
Ma C, Ling Q, Xu S, Zhu HZhang G* et al. Preparation of ,aggregation- induced emission homopolymeric nanoparticles for cell imaging. Macromol Biosci. 2014, 14(2):235-43.
Wang H, Zhang G, Zhang H, et al. Acquisition of epithelial-mesenchymal transition phenotype and cancer stem cell-like properties in cisplatin-resistant lung cancer cells through AKT/β-catenin/Snail signaling pathway.Eur J Pharmacol. 2014, 723:156-66.
?Fang R, Zhang G, Guo Q, et al. Nodal promotes aggressive phenotype via Snail-mediated epithelial-mesenchymal transition in murine melanoma. Cancer Lett. 2013, 333(1):66-75.
?Wang JY, Zheng YZ, Yang J, Lin YH, Dai SQ, Zhang G*. ?Elevated levels of serum amyloid A indicate poor prognosis in patients with esophageal squamous cell carcinoma. BMC Cancer. 2012, 12:365
?Zhang G, Liu WL, Zhang L, et al. Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma. Clin Dev Immunol. 2011, 384726
Yi YM, Zhang G, Zeng J, et al. A new tumor vaccine: FAPτ-MT elicits effective antitumor response by targeting indolamine2,3-dioxygenase in antigen presenting cells. Cancer Biol Ther. 2011, 11(10):866-73.
Xu BL#, Zhang G#, Ye H,? et al. The predominance of the Hungarian clone (ST 239-III) amongst hospital-acquired methicillin-resistant Staphylococcus aureus (HA-MRSA) isolates recovered throughout mainland China. J Hospt Infect. 2009, 71(3):245-255.?
Guo XZ#, Zhang G#, Wang JY, et al. Prognostic relevance of Centromere protein H expression in esophageal carcinoma. BMC Cancer. 2008, 8(1):233?
Liu WL, Zhang G, Wang JY, et al. Proteomics-based identification of autoantibody against CDC25B as a novel serum marker in esophageal squamous cell carcinoma. B.B.R.C. 2008, ?375(3):440-445
Liu W, Tang L, Zhang G, et al. Characterization of a novel c-type lectin-like gene, LESCtin: demonstration of carbohydrate binding and expression in sinusoidal endothelia cells of liver and lymph node. J. Biol. Chem. 2004, 279(18):18748-18758.
教学著作《微生物与免疫学》，科学出版社，副主编，2016.12
《基因工程药物》人民卫生出版社，参编，2016.03
《微生物与免疫学》十一五规划教材，人民卫生出版社，参编，2013.09
《微生物与免疫学习题集》人民卫生出版社，参编，2007.08
《医药分子生物学实验教程》中山大学出版社，参编，2008.03
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