联系方式办公电话：
电子邮箱：zhangyq65@mail.sysu.edu.cn
办公地址：中山大学药学院213室
简单介绍张元庆??教授，博导，于2015年10月从康奈尔大学医学院卫理公会研究所以“****二期”引进回中山大学药学院开展工作，从事微流控生物芯片在癌症转移、高通量药物筛选、生物组织工程、肿瘤干细胞等领域的应用研究。其科研成果以第一作者和通讯作者身份在Angewandte Chemie International Edition、Journal? of? the? American? Chemical? Society、Advanced Science等期刊上发表多篇高水平论文。其中，关于微流控芯片技术的科研成果，被Chemical & Engineering News（化学化工新闻）撰写题为“Chip Scales Up Studies Of Cancer Cell Metastasis”的研究亮点特别报导，在Nature网站以题为“Screening antimetastatic compounds using microfluidic-based tracking of cell migration”加以报道。美国科学新闻(Science News)等网络媒体对上述特别报道进行转载。这些研究工作对微流控芯片技术，生物技术与材料科学在癌症转移的预防和治疗等领域具有重要意义。
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研究方向DNA纳米材料用于分析新方法；多功能纳米材料用于癌症的诊断和治疗; 高通量微流控芯片用于癌症研究。
教育经历2006.09 - 2011.06?中国科学院上海应用物理所 博士
2000.09 - 2004.07?中国科学技术大学 学士
工作经历2015.10 -?至今???中山大学药学院教授
2011.07 - 2015.10?美国康奈尔大学医学院HMRI博士后
教学情况分析化学 本科生课程
药物仪器分析 研究生课程
社会/学术任职《药学学报》青年编委 第二届
广东省药学会生物医药分析专业委员会副主任委员
科研项目国家自然科学基金 面上项目 2021-2024；
广东省自然科学基金 ****项目 2017-2021;
国家自然科学基金 青年项目 2017-2019；
中山大学“****二期”启动项目 2015-2017；
中山大学青年教师重点培育计划 2016-2017；
中山大学重大项目培育和新兴、交叉学科资助计划 2017-2018;
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论著专利?
2021年
Ziyan Zhang, Qiaojuan Liu, Jizhou Tan, Xiaoxia Zhan, Ting Liu, Yuting Wang, Gen Lu*, Minhao Wu*, Yuanqing Zhang*. Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy.?Acta Pharmaceutica Sinica B. 2021; ASAP.
Jialang Zhuang, Siping Liang, Liang Chen, Fan Yang, Qin Huo, Minhao Wu*, Yuanqing Zhang*, Ni Xie*.?Utilizing a high-throughput microdevice to study breast tumor cells clustering and metastasis.?Anal Chim Acta. 2021;1151,338222.
Fan Lin, Yong Shao, Yingjie Wu, Yuanqing Zhang*. NIR light-Propelled Janus-Based Nanoplatform for Cytosolic-Fueled MicroRNA Imaging.?ACS??Appl. Mater. Interfaces. 2021; 13(3), 3713-3721.
2020年
Jialang Zhuang, Jizhou Tan, Chenglin Wu, Jie Zhang, Ting Liu, Chunhai Fan, Jiaping Li*, Yuanqing Zhang*.?Extracellular vesicles engineered with valency-controlled DNA nanostructures deliver CRISPR/Cas9 system for gene therapy.?Nucleic Acids Research, 2020, 48(16)，8870-8882.
Weiwei Qin, Liang Chen, Zhiru Wang, Qian Li*, Chunhai Fan, Minhao Wu, Yuanqing Zhang*.?Bioinspired DNA Nanointerface with Anisotropic Aptamers for Accurate Capture of Circulating Tumor Cells. Advanced Science. 2020;DOI: 10.1002/advs..
Liang Chen, Siping Liang, Yu Chen, Minhao Wu*, Yuanqing Zhang*. Destructing the Plasma Membrane with Activatable Vesicular DNA Nanopores.?ACS??Appl. Mater. Interfaces. 2020;12, 1: 96-105.
Yubing Liu, Dabin Chen, Weiqiong Zhang, Yuanqing Zhang*.?Mobile DNA tetrahedron on ultra-low adsorption lipid membrane for directional control of cell sensing.?Sensors and Actuators B: Chemical.?2020; 307, 127570.
2019年
Maosheng Xu, Kunsong Zhang, Yubing Liu, Jie Wang, Ke Wang*, Yuanqing Zhang*.?Multifunctional MoS2 nanosheets with Au NPs grown in situ for synergistic chemo-photothermal therapy.?Colloids and Surfaces B: Biointerfaces 2019; 184, 110510.
Jialang Zhuang, Jie Zhang, Minhao Wu, Yuanqing Zhang*?A Dynamic 3D Tumor Spheroid Chip Enables More Accurate Nanomedicine Uptake Evaluation. Advanced Science.?2019;?DOI: 10.1002/advs.
Ke Wang, Xi Liu, Jialang Zhuang, Yubing Liu, Maosheng Xu, Dong Xie, Junjia Chen*, Xiaoyong Zhang, Yen Wei,?Yuanqing Zhang*.?Small fluorescent albumin nanoparticles for targeted photothermal therapy via albumin-Binding protein pathways.?Colloids and Surfaces B: Biointerfaces 2019; 181,696-704.
Zhiru Wang, Weiwei Qin*, Jialang Zhuang, Minhao Wu, Qian Li, Chunhai Fan*, Yuanqing Zhang*.?Virus-Mimicking Cell Capture Using Heterovalency Magnetic DNA Nanoclaws. ACS??Appl. Mater. Interfaces. 2019; 11: 12244–12252.
2018年
Jialang Zhuang, Yongjian Wu, Liang Chen, Siping Liang, Minhao Wu, Ledu Zhou, Chunhai Fan, Yuanqing Zhang*. Single‐Cell Mobility Analysis of Metastatic Breast Cancer Cells. Advanced Science. 2018；DOI: 10.1002/advs..
Dabin Chen, Duanping Sun, Zhiru Wang, Weiwei Qin, Liang Chen, Ledu Zhou, Yuanqing Zhang*.?A DNA nanostructured aptasensor for the sensitive electrochemical detection of HepG2 cells based on multibranched hybridization chain reaction amplification strategy.??Biosensors and Bioelectronics.?2018; 117:416-421.
Zijun Zhao, Yu Chen, Ngiambudulu M. Francisco, Yuanqing Zhang*, Minhao Wu*.?The application of CAR-T cell therapy in hematological malignancies: Advantages and challenges.?Acta Pharmaceutica Sinica B.?2018; 8; 539-551.
Duanping Sun, Jing Lu, Dabin Chen,?Yunfei Jiang, Zhiru Wang, Weiwei Qin, Yanyan Yu, Zuanguang Chen, Yuanqing Zhang*.?Label-free electrochemical detection of HepG2 tumor cells with a self-assembled DNA nanostructure-based aptasensor. Sensors and Actuators B: Chemical. 2018; 268:359-367.
Yunfei Jiang, Duanping Sun, Zhixian Liang, Liang Chen, Yuanqing Zhang*, Zuanguang Chen*.?Label-free and competitive aptamer cytosensor based on layer-by-layer assembly of DNA-platinum nanoparticles for ultrasensitive determination of tumor cells.?Sensors and Actuators B: Chemical. 2018; 262:35-43.
Ke Wang, Jialang Zhuang, Yubing Liu, Maosheng Xu, Jingyuan Zhuang, Zuanguang Chen, Yen Wei,?Yuanqing Zhang*.?PEGylated chitosan nanoparticles with embedded bismuth sulfide for dual-wavelength fluorescent imaging and photothermal therapy.?Carbohydrate Polymers. 2018; 184:445-452.
2017年
Ke Wang, Jialang Zhuang, Liang Chen, Dazhuang Xu, Xiaoyong Zhang, Zuanguang Chen, Yen Wei, Yuanqing Zhang*.?One-pot synthesis of AIE based bismuth sulfide nanotheranostics for fluorescence imaging and photothermal therapy.?Colloids and Surfaces B: Biointerfaces 2017; 160(1): 297-304.
Duanping Sun, Zuanguang Chen, Minhao Wu*, Yuanqing Zhang*. Nanomaterial-based Microfluidic Chips for the Capture and Detection of Circulating Tumor Cells. Nanotheranostics 2017; 1(4):389-402. doi:10.7150/ntno.21268.?
Duanping Sun, Jing Lu, Xiangyan Wang, Yuanqing Zhang*, Zuanguang Chen*.?Voltammetric aptamer based detection of HepG2 tumor cells by using an indium tin oxide electrode array and multifunctional nanoprobes.?Microchimica Acta?2017; 84(9):?3487–3496.
Ying Zhu, Jichao Zhang, Aiguo Li, Yuanqing Zhang*, Chunhai Fan*.?Synchrotron-based X-ray microscopy for sub-100nm resolution cell imaging. Current Opinion in Chemical Biology. 2017; 15, 11-16.
Weiwei Qin, Guan Huang, Zuanguang Chen*, Yuanqing Zhang*.?Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy.?Frontiers in Pharmacology. 2017; 18, 1-8.
2016年之前
Yuanqing Zhang, Minhao Wu, Xin Han, Ping Wang, Lidong Qin*. High‐Throughput, Label-Free Isolation of Cancer Stem Cells on the Basis of Cell Adhesion Capacity.?Angewandte Chemie International Edition?2015; 127，10838-10842.
Yuanqing Zhang, Ledu Zhou, Lidong Qin*. Utilizing a High-Throughput Microfluidic Platform to Study Hypoxia-Driven Mesenchymal-Mode Cell Migration.?Integrative Biology?2015；?7，672-680.
Yuanqing Zhang, Ledu Zhou, Lidong Qin*. High-Throughput 3D Cell Invasion Chip Enables Accurate Cancer Metastatic Assays.?Journal of the American Chemical Society?2014; 136，?15257-15262.
Yuanqing Zhang, Weijia Zhang, Lidong Qin*. Mesenchymal-Mode Migration Assay and Antimetastatic Drug Screening with High-Throughput Microfluidic Channel Networks.?Angewandte Chemie International Edition?2014; 53，2344-2348.
Yuanqing Zhang, Xiaoping Xu, Lu Wang, Jun Lin, Ying Zhu, Zhi Guo, Yanhong Sun*, Hua Wang, Yun Zhao, Renzhong Tai, Xiaohan Yu, Chunhai Fan, Qing Huang*. Dendrimer-folate-copper conjugates as bioprobes for synchrotron X-ray fluorescence imaging.?Chemical Communications?2013; 49，10388-10390.
Yuanqing Zhang,?Yanhong Sun,?XiaopingXu,?Xuezhu Zhang,?Hua Zhu,?Liliang Huang,?Yujin Qi,?Yu-Mei Shen*. Synthesis, biodistribution, and microsingle photon emission computed tomography (SPECT) imaging study of technetium-99m labeled PEGylated dendrimer poly(amidoamine) (PAMAM)-folic acid conjugates.?Journal of Medicinal Chemistry.?2010; 53, 3262-72.
其他本课题组欢迎特聘研究员系列、博士后、研究助理和研究生等优秀科研人员加入。