个人简介?
陆明，博士，副教授。2007年毕业于中山大学，获博士学位，留校从事药剂学研究。2015-2016年赴美国普渡大学药学院Dr. Lynne S. Taylor课题组进行合作研究。研究兴趣为热熔挤出与3D打印药物制剂、药物无定形态与多晶型。研究成果主要发表在Chemical Communications, Communications Chemistry,?Crystal Growth&Design, International Journal of Pharmaceutics, Pharmaceutical Research等药剂学、化学和晶体学主流期刊上。
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ORCID: ?https://orcid.org/0000-0002-2622-1528
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ResearchGate: ?https://www.researchgate.net/profile/Ming_Lu26
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代表性专著章节?
1. Ming Lu. Chapter 9. Novel Excipients and Materials Used in 3D Printing of Pharmaceutical Dosage Forms. 3D and 4D Printing in Biomedical Applications: Process Engineering and Additive Manufacturing. Editor: Mohammed Maniruzzaman. Publisher: John Wiley, UK,?2019.
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2. Ming Lu. Chapter 10: Continuous cocrystallization of poorly soluble APIs to enhance dissolution. Practical Guide to Hot-Melt Extrusion: Continuous Manufacturing and Scale-Up Methodologies. Editor: Mohammed Maniruzzaman. Publisher: SmithersRapra, UK, 2015.
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代表性论文1.?Xizhen Li,⁺ Xiao Ou,⁺ Bingquan Wang,⁺ Haowei Rong, Bing Wang, Chao Chang, Baimei Shi, Lian Yu,?Ming Lu*. Nicotinamide: Seven new polymorphic structures revealed by melt crystallization and crystal structure prediction.?Communications Chemistry, 2020, 3, 152.?
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2. Xizhen Li, Xiao Ou, Haowei Rong, Siyong Huang, Jonas?Nyman, Lian Yu, Ming Lu.*?The twelfth solved structure of ROY: Single crystals of Y04 grown from melt microdroplets.?Crystal Growth & Design.?2020, 20(11): 7093-7097.
3. Xiao Ou,⁺ XizhenLi,⁺ Haowei Rong, Lian Yu, Ming Lu*. A general method for cultivating single crystals from melt?micro droplets.?Chemical Communications, 2020, 56:?9950-9953.?
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4.?Deen Huang, Ziyuan Xie, Qiuhong Rao, Evangelos Liamas, Piaopiao Pan, Shixia Guan*, Zhenyu Jason Zhang,?Ming Lu*, Qingguo Li*. Hot melt extrusion of heat-sensitive and high melting point drug: Inhibit the recrystallization of the prepared amorphous drug during extrusion to improve the bioavailability. International Journal of Pharmaceutics, 2019, 565: 316-324.
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5. Zhengwei Huang, Ling Lin, Cushla McGoverin, Hu Liu, Lili Wang, Qi (Tony) Zhou,?Ming Lu*, Chuanbin Wu. Dry powder inhaler formulations of poorly water-soluble itraconazole：A balance between in-vitro dissolution and in-vivo distribution is necessary.?International Journal of Pharmaceutics, 2018，551(1-2): 103-110.?
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6.?Yongcheng Li, Ming Lu*, Chuanbin Wu*. PVP VA64 as a novel release-modifier for sustained-release mini-matrices prepared via hot melt extrusion. Drug Delivery and Translation Research. 2018,?8(6): 1670-1678.?
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7.?Ling Lin, Guilan Quan, Tingting Peng, Zhengwei Huang, Vikramjeet Singh,?Ming Lu*, Chuanbin Wu*.?Development of fine solid-crystal suspension with enhanced solubility, stability, and aerosolization performance for dry powder inhalation. International Journal of Pharmaceuticals. 2017, 533(1): 84-92.
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8.?Ming Lu, Lynne S*. Taylor. Vemurafenib: A tetramorphic system displaying concomitant crystallization from the supercooled liquid. Crystal Growth & Design, 2016, 16 (10): 6033–6042.?
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9. Pin Dong, Ling Lin, Yongcheng Li, Zhengwei Huang, Tianqun Lang, Chuanbin Wu*, Ming Lu*. In-situ synchrotron wide-angle X-ray diffraction as a rapid method for cocrystal/salt screening. International Journal of Pharmaceutics. 2015, 496(1): 107-116.
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10.?Ming Lu, Zhefei Guo, Yongcheng Li, Huishi Pang, Ling Lin, Xin Pan*, Chuanbin Wu*. Application of hot melt extrusion for poorly water-soluble drugs: Limitations, Advances and Future prospects. Current Pharmaceutical Design. 2014, 20(3):369-387.?
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11.??Zhefei Guo, Ming Lu*, Yongcheng Li, Huishi Pang, Ling Lin, Xu Liu, Chuanbin Wu*. The utilization of drug-polymer interactions for improving the chemical stability of hot-melt extruded solid dispersions. Journal of Pharmacy and Pharmacology. 2014, 66(2): 285–296.
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12. Yongcheng Li, Huishi Pang, Zhefei Guo, Ling Lin, Yixuan Dong, Ge Li, Ming Lu*, Chuanbin Wu. Interactions between drugs and polymers influencing hot melt extrusion. Journal of Pharmacy and Pharmacology. 2014, 66(2): 148-166.
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13. Yuefang Zhao, Yuting Qin, Yang Liang, Haijuan Zou, Xiao Peng, Huan Huang, Ming Lu, Min Feng*. Salt-induced stability and serum-resistance of polyglutamate polyelectrolyte brushes/nuclear factor-κB p65 siRNA polyplex enhance the apoptosis and efficacy of doxorubicin. Biomacromolecules. 2013, 14(6): 1777?1786.?
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14. Xu Liu, Ming Lu*, Zhe fei Guo, Lin Huang, Xin Feng, Chuanbin Wu*. Improving the chemical stability of amorphous solid dispersion with cocrystal technique by hot melt extrusion. Pharmaceutical Research. 2012, 29（3）：806-817.?
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15.?Ming Lu, Xiang Zhao, Lan Chen, Xiaomin Xiong, Jingxiu Zhang, Kancheng Mai*, Chuanbin Wu*. Nucleation effect on polymorphism of melt-crystallized syndiotactic polystyrene. Polymer. 2011, 52(4): 1102-1106.?
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(⁺ Equal contribution, * Corresponding author)
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申请和授权专利?
1. 陆明，李锡祯，欧霄。化合物单晶及其制备方法。专利号：5.9。（申请日期：2019年10月23日，已公开）
2. 陆明，黄思咏，李锡祯，欧霄。化合物单晶及其制备方法。专利号：5.8。（申请日期：2019年10月23日，已公开）
3. 吴传斌，董品，陆明。?伊曲康唑的固体分散体制备方法和应用。专利号：7.6。(授权日期：2018年2月5日)
4. 吴传斌，林玲，陆明。伊曲康唑吸入粉雾剂及其制备方法。专利号：CN B。（授权日期：2017年11月24日）
5. 吴传斌，陆明，黎永诚。富马酸喹硫平缓释制剂及其制备方法。专利号：ZL8.2。（授权日期：2017年10月3日）
6.?吴传斌,陆明,郭喆霏.二氟尼柳固体分散体及其制备方法。专利号：CN A。（授权日期：2015年4月15日）
7.?吴传斌, 刘旭, 陆明. 一种难溶性药物共晶固体分散体及其制备方法。专利号：CN B。（授权日期：2012年12月5日）
?主持科研项目?
1. 广州市基础研究计划基础与应用基础研究项目。聚合物熔体高效诱导药物新晶型的分子机制研究，2020.1-2022.12。(主持，在研)
2. 广东省自然科学基金面上项目。基于过冷熔体高效筛选磺酰脲类和格列奈类降糖药物的潜在优势晶型及其调控机制研究，项目编号2020A，2020.3-2023.3。(主持，在研)
3. 广东省自然科学基金面上项目。基于小分子氢键组份的热敏性药物熔融温度调控及其在热熔挤出过程中稳定机制研究，2018.5-2021.4。?(主持，在研)
4. 广东省新药设计与评价重点实验室开放基金科研项目。基于过冷液体的药物多晶型研究，2018.9-2020.9。(主持，结题)
5. 国家自然科学基金面上青年基金。基于尺寸效应的剪切诱导聚合物晶型转变研究，项目编号**， 2012.1.-2014.12。(主持，结题)
6. 高校基本业务费青年教师培育项目。基于热熔挤出的药物-聚合物相互作用研究，项目编号12ykpy08， 2012.12.1.-2015.12.1。(主持，结题)
7. 广东省医学科研基金。热熔挤出构建伊曲康唑干粉吸入剂及其体内外评价，项目编号A**，2015.6-2017.6。(主持，结题)
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欢迎具有药学背景的同学报考本课题组研究生。
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