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电子邮箱：zhaocs@mail.sysu.edu.cn
办公地址：广州市大学城外环东路132号 中山大学药学院，邮编：510006
?赵春顺? ?博士，教授，博士生导师。2003毕业于沈阳药科大学药剂学专业，获理学博士学位；1995年7月至1997年8月于河北制药集团从事新药研发工作；1999年9月至2000年8月于石药集团从事新药研发工作；2009年11月至2010年11月在北卡罗来纳大学教堂山分校药学院从事靶向递药系统研究；2003年9月入职中山大学药学院。近几年来负责国家“十一五”科技重大专项“新药研究开发关键技术研究”专项、“大品种技术改造”专项、国家自然科学基金、广东省科技计划重点项目、平台项目、广州市科技计划重大项目等多项课题。同时，负责并完成企业合作项目30余项；申请专利9项，授权7项；国际PCT 2项，目前已获15个国家授权；发表研究论文60余篇。
?研究方向药物新剂型与新技术
?教学情况本科生：药剂学；药物制剂设计策略与实例
研究生：药物吸收与剂型设计
?主持科研项目国家自然科学基金面上项目，“原位肿瘤疫苗的光激活协同IDO阻断和抗骨重吸收用于乳腺癌骨转移治疗的研究” （**，2020-2023）
国家自然科学基金面上项目，“基于光触发同步释放ROS与药物的眼内长效植入系统的构建及其用于后囊浑浊防治的评价” （**，2017-2020）
国家自然科学基金面上项目，“双功能晶状体囊袋植入系统的构建与性能评价” （**，2012-2015）
广东省科技计划重点项目，“抗缺血性脑卒中候选药物--异吲哚酮类化合物的筛选及临床前研究”，（2015，2015B）
“十一五”国家科技重大专项“重大新药创制”项目“新药研究开发关键技术研究”专项，“高生物利用度及稳定性药物晶型的制备与分析技术及产业化应用”,（2009，2009ZX09501-022，分题负责人）；
“十一五”国家科技重大专项“重大新药创制”项目“大品种技术改造”专项，“丁苯酞高端制剂及其作用靶点、机理研究”，（2008，2008ZX09201-007，分题负责人）；
企业合作项目30余项。

?研究论文Yanjuan Huang, Zhanghong Xiao, Zilin Guan, Yifeng Shen, Yali Jiang, Xiaoyu Xu, Zeqian Huang, Chunshun Zhao^*. A light-triggered self-reinforced nanoagent for targeted chemophotodynamic therapy of breast cancer bone metastases via ER stress and mitochondria mediated apoptotic pathways. J. Control Release, 2020;319:119-134.?https://doi.org/10.1016/j.jconrel.2019.12.043
Zeqian Huang, Yanjuan Huang, Meixu Chen, Jie Chen, Zishan Zeng, Xiaoyu Xu, Binyao Huang, Yong Luo, Zhanghong Xiao, Yaqing Ding, Chunshun Zhao^*. Bone-targeted oxidative stress nanoamplifier for synergetic chemo/chemodynamic therapy of bone metastases through increasing generation and reducing elimination of ROS. Chemical Engineering Journal, 2020; 399:125667, https://doi.org/10.1016/j.cej.2020.125667
Xiaoyu Xu, Zishan Zeng, Jie Chen, Binyao Huang, Zilin Guan, Yanjuan Huang, Zeqian Huang, Chunshun Zhao^*. Tumor-targeted supramolecular catalytic nanoreactor for synergistic chemo/chemodynamic therapy via oxidative stress amplification and cascaded Fenton reaction. Chemical Engineering Journal, 2020; 390:124628, https://doi.org/10.1016/j.cej.2020.124628
Yanjuan Huang^#, Yali Jiang^#, Zhanghong Xiao^#, Yifeng Shen, Liangfeng Huang, Xiaoyu Xu, Gaofei Wei, Congjun Xu, Chunshun Zhao^? . Three birds with one stone: A ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/ chemodynamic therapy with glutathione depletion. Chemical Engineering Journal, 2020;380:122369.
Yanjuan Huang, Zhanghong Xiao, Zilin Guan, Zishan Zeng, Yifeng Shen, Xiaoyu Xu, Chunshun Zhao^*. Bone-seeking nanoplatform co-delivering cisplatin and zoledronate for synergistic therapy of breast cancer bone metastasis and bone resorption. Acta Pharmaceutica Sinica B, 2020;10(12):2384-2403. https://doi.org/10.1016/j.apsb.2020.06.006
Xiaoyu Xu^#, Binyao Huang^#, Zishan Zeng, Jie Chen, Zeqian Huang, Zilin Guan, Meixu Chen, Yanjuan Huang, Chunshun Zhao^*. Broaden sources and reduce expenditure: Tumor-specific transformable oxidative stress nanoamplifier enabling economized photodynamic therapy for reinforced oxidation therapy. Theranostics, 2020; 10(23): 10513-10530. doi: 10.7150/thno.49731
Xiaoyu Xu, Zishan Zeng, Zeqian Huang, Yangwen Sun, Yanjuan Huang, Jie Chen, Junxian Ye, Haolan Yang, Chanzhen Yang, Chunshun Zhao^?. Near-infrared light-triggered degradable hyaluronic acid hydrogel for ondemand drug release and combined chemo-photodynamic therapy. Carbohydrate Polymers, 2020; 229:115394.
Xiaoqi Sun, Di Liu, Xiaoyu Xu, Yifeng Shen, Yanjuan Huang, Zishan Zeng, Meng Xia, Chunshun Zhao^*. NIR-triggered thermo-responsive biodegradable hydrogel with combination of photothermal and thermodynamic therapy for hypoxic tumor. Asian Journal of Pharmaceutical Sciences,?2020; 15(6): 713-727. https://doi.org/10.1016/j.ajps.2019.1007
Zeqian Huang^#, Gaofei Wei^#, Zishan Zeng, Yanjuan Huang, Liangfeng Huang, Yifeng Shen, Xiaoqi Sun, Congjun Xu, Chunshun Zhao*. Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor. Theranostics, 2019; 9(19):5542-5557.
Gaofei Wei, Liangfeng Huang, Yifeng Shen, Zeqian Huang, Xiaoyu Xu, and Chunshun Zhao*. Porphyrin-based porous organic frameworks as oxygen reservoirs to overcome tumor hypoxia for enhanced photodynamic therapy. Advanced Therapeutics, .
Gaofei Wei^#*, LiangfengHuang^#, YaliJiang^#, YifengShen, ZeqianHuang, YanjuanHuang, XiaoqiSun,? Chunshun Zhao*. Lenvatinib-zinc phthalocyanine conjugates as potential agents for enhancing synergistic therapy of multidrug-resistant cancer by glutathione depletion. Eur J Med Chem., 2019; 169:53-64.
Liangfeng Huang^#, Gaofei Wei^#,*, Xiaoqi Sun, Yali Jiang, Zeqian Huang, Yanjuan Huang, Yifeng Shen, Xiaoyu Xu, Yunhui Liao, Chunshun Zhao*. A tumor-targeted Ganetespib-zinc phthalocyanine conjugate for synergistic chemo-photodynamic therapy. Eur J Med Chem., 2018; 151: 294-303.
Xuefei Zhang, Binyao Huang, Yifeng Shen, Chanzhen Yang, Zeqian Huang, Yanjuan Huang, Xiaoyu Xu, Yali Jiang, Xiaoqi Sun, Xining Li, Mina Yan and Chunshun Zhao*. Near infrared light triggered reactive oxygen species responsive nanoparticles for chemo-photodynamic combined therapy. J. Mater. Chem. B, 2018; 6: 2347-2357.
Yuanfeng He¹, Yanjuan Huang¹, Ziyuan Huang, Yali Jiang, Xiaoqi Sun, Yifeng Shen, Weijing Chu, Chunshun Zhao*. Bisphosphonate-functionalized coordination polymer nanoparticles for the treatment of bone metastatic breast cancer. J Control Release. 2017; 264:76-88.
Xiaoyu Xu, Ziyuan Huang, Zeqian Huang, Xuefei Zhang, Siyu He, Xiaoqi Sun, Yifeng Shen, Mina Yan, Chunshun Zhao*. Injectable, NIR/pH-Responsive Nanocomposite Hydrogel as Long-Acting Implant for Chemo-Photothermal Synergistic Cancer Therapy. ACS Appl Mater Interfaces. 2017;9(24):20361-20375
Yanjuan Huang, Yuanfeng He, Ziyuan Huang, Yali Jiang, Weijing Chu, Xiaoqi Sun, Liangfeng Huang, Chunshun Zhao*. Coordination self-assembly of platinum-bisphosphonate polymer-metal complex nanoparticles for cisplatin delivery and effective cancer therapy. Nanoscale. 2017,?9:10002-10019
Ziyuan Huang, Liangfeng Huang, Yanjuan Huang, Yuanfeng He, Xiaoqi Sun, Xiang Fu, Xiaoyu Xu, Gaofei Wei, Dawei Chen and Chunshun Zhao*. Phthalocyanine-based coordination polymer nanoparticles for enhanced photodynamic therapy. Nanoscale.?2017, 9, 15883–15894.
Weijing Chu, Yanjuan Huang, Chanzhen Yang, Yunhui Liao, Xuefei Zhang, Mina Yan, Shengmiao Cui*, Chunshun Zhao*. Calcium phosphate nanoparticles functionalized with alendronate- conjugated polyethylene glycol (PEG) for the treatment of bone metastasis.?Int J Pharm., 2017; 516(1-2):352–363
Mina Yan, Chanzhen Yang, Binyao Huang, Zeqian Huang, Liangfeng Huang, Xuefei Zhang, Chunshun Zhao^*. Systemic toxicity induced by aggregated layered double hydroxide nanoparticles.? Int J Nanomed. 2017; 12: 7183–7195.
Jiani Huang, Wenyan Gong, Zhiquan Chen, Junying Huang, Qiuhong Chen, Heqing Huang*, Chunshun Zhao*. Emodin self-emulsifying platform ameliorates the expression of FN, ICAM-1 and TGF-β1 in AGEs-induced glomerular mesangial cells by promoting absorption. Eur J Pharm Sci. 2017; 99:128-136.
Ming Lei, Zihang Peng, Qian Dong, Yuanfeng He, Zhaoguo Zhang, Xuefei Zhang, Mina Yan, Chunshun Zhao*. A Novel Capsular Tension Ring as Local Sustained-Release Carrier for Preventing Posterior Capsule Opacification. Biomaterials, 2016; 89:148-156.
Yunhui Liao, Xuefei Zhang, Chenglin Li, Yanjuan Huang, Ming Lei, Mina Yan,Yuefang Zhou, Chunshun Zhao*. Inclusion complexes of HP-β-cyclodextrin with agomelatine:Preparation, characterization, mechanism study and in vivo evaluation. Carbohydrate Polymers, 2016;147: 415–425
Zhaoguo Zhang, Wenyong Huang, Ming Lei, Yuanfeng He, Mina Yan, Xuefei Zhang, Chunshun Zhao*. Laser-triggered intraocular implant to induce photodynamic therapy for posterior capsule opacification prevention. Int J Pharm., 2016;498:1-11
Mina Yan, Zhaoguo Zhang, Shengmiao Cui, Xuefei Zhang,Weijing Chu, Ming Lei, Ke Zeng, Yunhui Liao, Yihui Deng*, Chunshun Zhao*. Preparation and evaluation of PEGylated phospholipid membrane coated layered double hydroxide nanoparticles. Asian J of Pharm. Sci., 2016:396-403
Ke Zeng, Jin Li, Zhaoguo Zhang, Mina Yan, Yunhui Liao, Xuefei Zhang, Chunshun Zhao*. Lipid-coated ZnO nanoparticles as lymphatictargeted drug carriers: study on cell-specific toxicity in vitro and lymphatic targeting in vivo. J. Mater. Chem. B, 2015,3(26):5249-5260
Zujian Lan, Xiaoyu Xu, Wenkai Xu, Jin Li, Zengrong Liang, Xuefei Zhang, Ming Lei, Chunshun Zhao*. Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent. Drug Des Devel Ther., 2015;9:3377-3391
Huafang Zhang, Yan Xiao, Shengmiao Cui, Yuefang Zhou, Ke Zeng, Mina Yan, Chunshun Zhao*. Novel galactosylated poly(ethylene glycol)-cholesterol for liposomes as a drug carrier for hepatocyte-targeting. J of Nanosci and Nanotech., 2015;15(6):4058-4069
Mina Yan, Zhaoguo Zhang, Shengmiao Cui, Ming Lei, Ke Zeng, Yunhui Liao, Weijing Chu, Yihui Deng*, Chunshun Zhao*. Improvement of pharmacokinetic and antitumor activity of layered double hydroxide nanoparticles by coating with PEGylated phospholipid membrane. Int J Nanomed. 2014;9(1):4867-4878
Yuefang Zhou, Weijing Chu, Ming Lei, Jin Li, Wei Du, Chunshun Zhao*. Application of a continuous intrinsic dissolution-permeation system for relative bioavailability estimation of polymorphic drugs. Int J Pharm., 2014;473(1-2):250-258.
Qian Dong, Shaoling Yi, Zihang Peng, Chunshun Zhao*. The preparation and the in vitro pharmacodynamics study of the intracapsular prolong-preparations for the prevention of posterior capsule opacification. Asian J of Pharm. Sci., 2013;8(5):259-267
Wei Du, Yuefang Zhou, Yafei Gong, Chunshun Zhao*. Investigation of physicochemical properties and in-vitro in-vivo evaluation of agomelatine polymorphs. Asian J of Pharm. Sci., 2013;8(4):181-190
Yan Xiao, Huafang Zhang, Zhaoguo Zhang, Mina Yan, Ming Lei, Ke Zeng, Chunshun Zhao*. Synthesis of novel tetravalent galactosylated DTPA-DSPE and study on the hepatocyte targeting efficiency in vitro and in vivo. Int J Nanomed. 2013; 8:3033-3050.
Wanwen Li, Shaoling Yi, Zhouhua Wang, Si Chen, Shuang Xin, Jingwen Xie, Chunshun Zhao*. Self-nanoemulsifying drug delivery system of persimmon leaf extract: Optimization and bioavailability studies. Int J Pharm. 2011; 420(1):161-171.