所系名称
中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室
性别
男
专业名称
海洋生物学
技术职务
副研究员
行政职务

Mail地址
yangbin@scsio.ac.cn
指导博士生总数
0
指导硕士生总数
0
通讯地址
广州新港新路164号实验楼603
目前博士生数
0
目前硕士生数
0
邮政编码
510301
研究方向
海洋天然药物化学。

研究工作
主要的研究方向为海洋无脊椎动物及其共附生微生物的化学生态和药效物质基础研究，聚焦于我国南海珊瑚微生物资源库的构建，从中高效挖掘和系统评价海洋微生物来源药物潜力次生代谢产物。近年来从20 余株南海特殊真菌中，分离得到了近400 个化合物，其中180 多个新化合物，筛选发现发现约30 多个化合物显示了显著的抗肿瘤活性，另外有40 余个化合物显示了抗炎、老年痴呆、糖尿病等活性，为海洋微生物资源的高效利用和我国海洋药物研发作出贡献。先后主持基金9 项，包括主持国家自然科学基金3 项；广东省自然科学基金2 项；广州市科技计划项目1 项；发表SCI 论文60 余篇，其中第一作者或通讯作者论文28 篇；申请专利5 件，参编专著4 部；协助指导研究生6名。
获奖情况

指导研究生情况

个人简介
教育经历：
2005.9–2010.6, 中国科学院南海海洋研究所, 海洋化学, 硕博连读, 导师: 董俊德，刘永宏
2000.9–2004.6, 湖南师范大学, 生物技术, 学士
工作经历：
2017.12-至今, 中国科学院南海海洋研究所, 中国科学院热带海洋生物资源与生态重点实验室, 副研究员
2010.7-2017.12, 中国科学院南海海洋研究所, 中国科学院热带海洋生物资源与生态重点实验室, 助理研究员
科研成果
论文发表（第一或通讯作者）
1.Luo, X.-W.; Gao, C.-H.; Lu, H.-M.; Wang, J.-M.; Su, Z.-Q.; Tao, H.-M.; Zhou, X.-F.; Yang, B.; Liu, Y.-H. HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17. Molecules 2020, 25.
2.Long, J.-Y.; Wang, J.-F.; Liao, S.-R.; Lin, X.-P.; Zhou, X.-F.; Li, Y.-Q.; Yang, B.; Liu, Y.-H. Four new steroids from the marine soft coral-derived fungus Penicillium sp. SCSIO41201. Chinese journal of natural medicines 2020, 18, 250-255.
3.Lin, X.; Ai, W.; Li, M.; Zhou, X.; Liao, S.; Wang, J.; Liu, J.; Yang, B.; Liu, Y. Collacyclumines A-D from the endophytic fungus Colletotrichum salsolae SCSIO 41021 isolated from the mangrove Kandelia candel. Phytochemistry 2020, 171.
4.Salendra, L.; Lin, X.; Chen, W.; Pang, X.; Luo, X.; Long, J.; Liao, S.; Wang, J.; Zhou, X.; Liu, Y.; Yang, B. Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017. Natural Product Research 2019, 1-9.
5.Li, Y.; Tan, Y.; Liu, J.; Zhou, X.; Zeng, S.; Dong, J.; Liu, Y.; Yang, B. A new griseofulvin derivative from a soft coral-derived fungus Eupenicillium sp. SCSIO41208. Natural Product Research 2019, 1-5.
6.Huang, J.; She, J.; Yang, X.; Liu, J.; Zhou, X.; Yang, B. A New Macrodiolide and Two New Polycyclic Chromones from the Fungus Penicillium sp. SCSIO041218. Molecules (Basel, Switzerland) 2019, 24.
7.Yang, B.; Tao, H.; Lin, X.; Wang, J.; Liao, S.; Dong, J.; Zhou, X.; Liu, Y. Prenylated indole alkaloids and chromone derivatives from the fungus Penicillium sp. SCSIO041218. Tetrahedron 2018, 74, 77-82.
8.Yang, B.; Huang, J.; Zhou, X.; Lin, X.; Liu, J.; Liao, S.; Wang, J.; Liu, F.-a.; Tao, H.; Liu, Y. The Fungal Metabolites with Potential Antiplasmodial Activity. Current Medicinal Chemistry 2018, 25, 3796-3825.
9.Tao, H.; Li, Y.; Lin, X.; Zhou, X.; Dong, J.; Liu, Y.; Yang, B. A New Pentacyclic Ergosteroid from Fungus Aspergillus sp. SCSIO41211 Derived of Mangrove Sediment Sample. Natural Product Communications 2018, 13, 1629-1631.
10. Tan, Y.; Yang, B.; Lin, X.; Luo, X.; Pang, X.; Tang, L.; Liu, Y.; Li, X.; Zhou, X. Nitrobenzoyl Sesquiterpenoids with Cytotoxic Activities from a Marine-Derived Aspergillus ochraceus Fungus. Journal of Natural Products 2018, 81, 92-97.
11. Limbadri, S.; Luo, X.; Lin, X.; Liao, S.; Wang, J.; Zhou, X.; Yang, B.; Liu, Y. Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012. Molecules 2018, 23.
12. Dai, Y.; Lin, Y.; Pang, X.; Luo, X.; Salendra, L.; Wang, J.; Zhou, X.; Lu, Y.; Yang, B.; Liu, Y. Peptides from the Soft Coral-associated Fungus Simplicillium sp. SCSIO41209. Phytochemistry 2018, 154, 56-62.
13. Yang, B.; Tao, H.; Qin, X.-C.; Wang, Z.; Dong, J.; Lin, X.; Zhou, X.; Li, J.-L.; Tu, Z.-C.; Liu, Y. Aspergone, a new chromanone derivative from fungus Aspergillus sp SCSIO41002 derived of mangrove soil sample. Journal of Antibiotics 2017, 70, 788-790.
14. Tao, H.M.; Wei, X.Y.; Lin, X.P.; Zhou, X.F.; Dong, J.D.; Yang, B. Penixanthones A and B, two new xanthone derivatives from fungus Penicillium sp SYFz-1 derived of mangrove soil sample. Natural Product Research 2017, 31, 2218-2222.
15. Tan, S.; Yang, B.; Liu, J.; Xun, T.; Liu, Y.; Zhou, X. Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent. Natural Product Research 2017, 33, 1467-1471.
16. Liu, F.-a.; Lin, X.; Zhou, X.; Chen, M.; Huang, X.; Yang, B.; Tao, H. Xanthones and Quinolones Derivatives Produced by the Deep-Sea-Derived Fungus Penicillium sp. SCSIO Ind16F01. Molecules 2017.
17. Yang, B.; Huang, J.; Lin, X.; Zhang, Y.; Tao, H.; Liu, Y. A New Diketopiperazine from the Marine Sponge Callyspongia Species. Records of Natural Products 2016, 10, 117-121.
18. Yang, B.; Huang, J.; Li, X.; Lin, X.; Zhou, X.; Tao, H.; Liu, Y. Isolation, Characterization, and Bioactivity Evaluation of Alkaloids from Soft Coral Sinularia kotanianensis. Chemistry of Natural Compounds 2016, 52, 564-566.
19. Yang, B.; Huang, J.; Lin, X.; Liao, S.; Zhou, X.; Liu, J.; Wang, J.; Wang, L.; Liu, Y. New Casbane Diterpenoids from the Hainan Soft Coral Sinularia Species. Helvetica Chimica Acta 2015, 98, 834-841.
20. Yang, B.; Wei, X.; Huang, J.; Lin, X.; Liu, J.; Liao, S.; Wang, J.; Zhou, X.; Wang, L.; Liu, Y. Sinulolides A-H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp. Marine Drugs 2014, 12, 5316-5327.
21. Yang, B.; Dong, J.; Lin, X.; Zhou, X.; Zhang, Y.; Liu, Y. New prenylated indole alkaloids from fungus Penicillium sp derived of mangrove soil sample. Tetrahedron 2014, 70, 3859-3863.
22. Yang, B.; Dong, J.; Lin, X.; Tao, H.; Zhou, X.; Liu, Y. Xylaolide A, a new lactone from the fungus Xylariaceae sp DPZ-SY43. Natural Product Research 2014, 28, 967-970.
23. Yang, B.; Tao, H.; Zhou, X.; Lin, X.-P.; Liu, Y. Two new alkaloids from marine sponge Callyspongia sp. Natural Product Research 2013, 27, 433-437.
24. Yang, B.; Liao, S.; Lin, X.; Wang, J.; Liu, J.; Zhou, X.; Yang, X.; Liu, Y. New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp. Marine Drugs 2013, 11, 4741-4750.
25. Yang, B.; Zhou, X.-F.; Lin, X.-P.; Liu, J.; Peng, Y.; Yang, X.-W.; Liu, Y. Cembrane Diterpenes Chemistry and Biological Properties. Current Organic Chemistry 2012, 16, 1512-1539.
26. Yang, B.; Zhou, X.; Huang, H.; Yang, X.-W.; Liu, J.; Lin, X.; Li, X.; Peng, Y.; Liu, Y. New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp. Marine Drugs 2012, 10, 2023-2032.
27.Yang, B.; Hu, J.; Lei, H.; Chen, X.-q.; Zhou, X.-f.; Liu, Y.-h. Chemical constituents of marine sponge Callyspongia sp from the South China Sea. Chemistry of Natural Compounds 2012, 48, 350-351.
28.Yang, B.; Dong, J.; Zhou, X.; Yang, X.; Lee, K.J.; Wang, L.; Zhang, S.; Liu, Y. Proline-Containing Dipeptides from a Marine Sponge of a Callyspongia Species. Helvetica Chimica Acta 2009, 92, 1112-1117.
授权发明专利
1.环脯氨酸-亮氨酸在海洋污损生物防除中的应用.专利号： ZL4.6
2.环脯氨酸-2-N-羟基-异亮氨酸在海洋污损生物防除中的应用. 专利号：ZL5.0
3. 一种深海海旋菌及其应用. 专利号：ZL3.X
4.吡啶酮生物碱类化合物及其制备方法和在制备抗肿瘤药物中的应用。专利号：ZL0.4.
5.生物碱类化合物在制抗肠道病毒及乙酰胆碱酯酶抑制剂药物中的应用。专利号：ZL5.4.
参编专著：
1. Bin Yang, Xiuping Lin, Xuefeng Zhou, Xianwen Yang, and Yonghong Liu. Chemical and Biological Aspects of Marine Cosmeceuticals. Marine Cosmeceuticals Trends and Prospects. ISBN: 81, CRC Press, 2011. P11–38.
2. Bin Yang, Juan Liu, Junfeng Wang, Shengrong Liao and Yonghong Liu. Cytotoxic Cembrane Diterpenoids. Handbook of Anticancer Drugs from Marine Origin. ISBN: 978-3-319-07144-2, Springer publishers, 2015. P649-672.
3. Jing Hu, Bin Yang, Xiuping Lin, XueFeng Zhou, XianWen Yang, and Yonghong Liu. Bioactive metabolites from seaweeds. Handbook of Marine Macroalgae: Biotechnology and Applied Phycology. Online ISBN: 87, Wiley-Blackwell publisher, 2011. P262–284.