所系名称
中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室
性别
女
专业名称
海洋生物学
技术职务
副研究员
行政职务

Mail地址
shiyu1002@scsio.ac.cn
指导博士生总数
0
指导硕士生总数
0
通讯地址
广东省广州市海珠区新港西路164号标本楼502室
目前博士生数
0
目前硕士生数
0
邮政编码
510301
研究方向
海洋贝类生长、抗逆、生殖发育、生物矿化等的分子解析和调控机制。

研究工作
主要从事海洋贝类的分子生物学及功能基因组学研究，1）首次系统性的解释了马氏珠母贝个体大小差异现象以及补偿性生长现象；2）系统性的阐释了马氏珠母贝珍珠形成的机理；3）首次发现马氏珠母贝中存在胰岛素样信号系统；4）首次发现华贵栉孔扇贝雌雄同体现象的调控机制；5）首次从进化上解析塔螺的生物矿化分泌蛋白。
获奖情况

指导研究生情况
协助指导研究生情况：
博士研究生：许濛（2017级）
Meng Xu, Jing Huang, Yu Shi, Hua Zhang, Maoxian He*, Comparative transcriptomic and proteomic analysis of yellow shell and black shell pearl oysters, Pinctada fucata martensii, BMC Genomics, 2019, 20: 469
博士研究生：赵密（2010级）
Mi Zhao, Maoxian He*, Xiande Huang, Qi Wang, Yu Shi, Functional characterization and molecular mechanism exploration of three granulin epithelin precursor splice variants in biomineralization of the pearl oyster Pinctada fucata, Mol Genet Genomics, 2016, 299 (1): 399-409
博士研究生：王琦（2009级）
Pf-Dmrt4, a potential factor in sexual development in the pearl oyster Pinctada fucata, Qi Wang, Yu Shi, Maoxian He*, Journal of Oceanology and Limnology, 2018, 36: 2337-2350
个人简介
教育背景：
2006/09 - 2011/06，中山大学，海洋生物学专业，博士
2002/09 - 2006/06，西南大学，生物技术专业，学士
工作经历：
2017/12 - 至今，中国科学院南海海洋研究所，海洋生物研究室，副研究员
2014/01 - 2017/11，中国科学院南海海洋研究所，海洋生物研究室，助理研究员一级
2011/07 - 2013/12，中国科学院南海海洋研究所，海洋生物研究室，助理研究员二级
科研成果
论文发表（第一或通讯作者）：
1.Yu Shi, Mi Zhao, Maoxian He*, PfSMAD1/5 Can Interact with PfSMAD4 to Inhibit PfMSX to Regulate Shell Biomineralization in Pinctada fucata martensii, Mar Biotechnol, 2020, 22: 246-262
2. Yu Shi, Meng Xu, Jing Huang, Hua Zhang, Wenguang Liu, Zekui Ou, Maoxian He*, Transcriptome analysis of mantle tissues reveals potential biomineralization-related genes in Tectus pyramis Born, Comp Biochem Phys D, 2019, 29: 131-144
3. Yu Shi, Wenguang Liu, Maoxian He*, Proteome and Transcriptome Analysis of Ovary, Intersex Gonads, and Testis Reveals Potential Key Sex Reversal/Differentiation Genes and Mechanism in Scallop Chlamys nobilis, Mar Biotechnol, 2018, 20 (2):220-245
4. Hua Zhang, Mi Zhaoa, Xuejie Yi, Zekui Ou, Yaoguo Li, Yu Shi*, Maoxian He*, Characterization of the distal-less homologue gene, PfDlx, involved in regulating the expression of Pif in the pearl oyster, Pinctada fucata, Comp Biochem Phys B, 2017, 212: 51-58
5. Yu Shi, Maoxian He*, PfIRR Interacts with HrIGF-I and Activates the MAP-kinase and PI3-kinase Signaling Pathways to Regulate Glycogen Metabolism in Pinctada fucata, Sci Rep-UK, 2016, 6: 22063
6. Mi Zhao#, Yu Shi#, Maoxian He*, et al., PfSMAD4 plays a role in biomineralization and can transduce bone morphogenetic protein-2 signals in the pearl oyster Pinctada fucata, BMC Dev Biol, 2016, 16:9
7. Wan Peng#, Yu Shi#, Gaofei Li, 1, Liangge He , Yaosi Liang, Yong Zhang, Libin Zhou, Haoran Lin, Danqi Lu*, Tetraodon nigroviridis: A model of Vibrio parahaemolyticus infection, Fish Shellfish Immun, 2016, 56: 388-396
8.Yu Shi, Qi Wang, Maoxian He*, Molecular identification of dmrt2 and dmrt5 and effect of sex steroids on their expressions in Chlamys nobilis, Aquaculture, 2014, 426–427: 21-30
9.Yu Shi, Yunyan Guan, Maoxian He*, Molecular identification of insulin-related peptide receptor and its potential role in regulating development in Pinctada fucata, Aquaculture, 2013, 408–409: 118-127
10.Yu Shi, Maoxian He*, Differential gene expression identified by RNA-Seq and qPCR in two sizes of pearl oyster (Pinctada fucata), Gene, 2014, 538(2): 313-322
11.Yu Shi, Xiaochun Liu, Haifa Zhang, Yong Zhang, Danqi Lu, Haoran Lin*, Molecular identification of an androgen receptor and its changes in mRNA levels during 17 alpha-methyltestosterone-induced sex reversal in the orange-spotted grouper Epinephelus coioides, Comp Biochem Phys B, 2012, 163(1): 43-50
12. Yu Shi, Yong Zhang, Shuisheng Li, Qing Liu, Danqi Lu, Min Liu, Zining Meng, Christopher H.K. Cheng, Xiaochun Liu*, Lin, Haoran, Molecular Identification of the Kiss2/Kiss1ra System and Its Potential Function During 17Alpha-Methyltestosterone-Induced Sex Reversal in the Orange-Spotted Grouper, Epinephelus coioides, Biol Reprod, 2010, 83 (1):63-74