所系名称
中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室
性别
男
专业名称
海洋生物学
技术职务
副研究员
行政职务

Mail地址
yunxueguo@scsio.ac.cn
指导博士生总数
0
指导硕士生总数
0
通讯地址
广州市新港西路164号2号楼302
目前博士生数
0
目前硕士生数
0
邮政编码
510301
研究方向
海洋微生物活性物质与功能基因。

研究工作
主要从事模式和海洋微生物中毒素-抗毒素系统（Toxin-Antitoxin system, TA）的功能和调控机制研究。取得的主要成果包括：（1）发现原噬菌体携带新颖的I型和IV型TA系统，揭示其在生物膜和顽固耐药菌形成中的作用；（2）揭示原噬菌体携带的TA系统调控病毒粒子产生、细菌生物膜形成、致病性和低温环境适应过程；（3）阐明了不同类型和同一类型不同来源的TA间相互作用的方式及调控机制；（4）在国际上率先开展了海洋微生物中TA系统的功能及调控研究，发现新型的TA系统及抗毒素拮抗毒素毒性的全新方式。TA相关的研究工作先后获国家自然科学基金面上和青年基金项目、中国博士后科学基金特别资助和面上项目、2项广东省自然科学基金的资助。
获奖情况

指导研究生情况
协助实验室PI指导2名硕士研究生和1名博士研究生，均有II区以上SCI论文发表。
个人简介
教育经历：
2009/9 - 2012/6，中山大学，生命科学学院，博士
2006/9 - 2009/6，广东海洋大学，水产学院，硕士
2002/9 - 2006/6，河北大学，生命科学学院，学士
工作经历：
2017/01 –至今，中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室，副研究员
2015/01 -2016/12，中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室，助理研究员
2014/5 - 2014/11，宾夕法尼亚州立大学，化学工程系，博士后
2012/7 -2014/12，中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室，博士后

科研成果
1)Fu X, Guo YX, Jin YG, Ma MH * (2020) Bioconversion of chitin waste using a cold-adapted chitinase to produce chitin oligosaccharides. LWT-Food Science and Technology, doi.org/10.1016/j.lwt.2020.109863.
(2) Ma B, Guo YX, Fu X *, Jin YG * (2020). Identi？cation and antimicrobial mechanisms of a novel peptide derived from egg white ovotransferrin hydrolysates. LWT-Food Science and Technology, doi.org/10.1016/j.lwt.2020.109720.
(3)Li YM^#, Liu XX^#, Tang KH, Wang WQ, Guo YX*, Wang XX* (2020). Prophage encoding toxin/antitoxin system PfiT/PfiA inhibits Pf4 production in Pseudomonas aeruginosa. Microbial Biotechnology, 13(4), 1132–1144.
(4)Li BY, Yin F, Zhao XY, Guo YX, Wang WQ, Wang PX, Zhu HU, Yin YS, Wang XX*. (2020). Colistin Resistance Gene mcr-1 Mediates Cell Permeability and Resistance to Hydrophobic Antibiotics.Frontiers in Microbiology,10, 3015.
(5)Wang PX, He DM, Li BY, Guo YX, Luo XJ, Wang WQ, Zhao XY, Wang XX* (2019). Eliminating mcr-1-harbouring plasmids in clinical isolates using the CRISPR/Cas9 system. Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkz246. (IF:5.439)
(6)Guo YX^#, Sun CL^#, Li YM, Tang KH, Ni SW, Wang XX* (2019). Antitoxin HigA inhibits virulence gene mvfR expression in Pseudomonas aeruginosa. Environmental Microbiology, 21(8), 2707–2723. (IF:4.933)
(7)Guo YX^*, Li YM, Zhan WE, Wood TK, Wang XX (2019). Resistance to oxidative stress by inner membrane protein ElaB is regulated by OxyR and RpoS. Microbial Biotechnology, 12(2): 392-404. (IF:5.328)
(8)Zhan WE, Yao JY, Li YM, Guo YX*, Wang XX* (2019). Characterization of two toxin-antitoxin systems in deep-sea Streptomyces sp. SCSIO 02999. Marine Drugs, 17(4): 211. (IF:4.073)
(9)Song S, Guo YX, Kim JS, Wang XX*, Wood TK* (2019). Phages mediate bacterial self-recognition. Cell Reports, 27: 737–749. (IF:8.109)
(10)Li YM, Liu XX, Tang KH, Wang PX, Zeng ZS, Guo YX, Wang XX* (2019). Excisionase in Pf filamentous prophage controls lysis-lysogeny decision-making in Pseudomonas aeruginosa. Molecular Microbiology, 111(2): 495-513. (IF:3.418)
(11) Yao JY, Guo YX, Wang PX, Zeng ZS, Li BY, Tang KH, Liu XX, Wang XX* (2018). Type II toxin/antitoxin system ParE_SO /CopA_SO stabilizes prophage CP4So in Shewanella oneidensis. Environmental Microbiology. 20, 1224-1239.
(12)Li BY, Ke BX, Zhao XY, Guo YX, Wang WQ, Wang XX, & Zhu HH*. (2018). Antimicrobial resistance profile of mcr-1 positive clinical isolates of Escherichia coli in China from 2013-2016.Frontiers in Microbiology,9, 2514.
(13) Guo YX, Liu XX, Li BY, Yao JY, Wood TK, Wang XX* (2017). Tail-anchored inner membrane protein ElaB increases resistance to stress while reducing persistence in Escherichia coli. Journal of Bacteriology, 199:e00057-17.
(14)Sun CL, Guo YX, Tang KH, Wen ZL, Li BY, Zeng ZS, Wang XX* (2017). MqsR/MqsA toxin/antitoxin system regulates persistence and biofilm formation in PseudomonasputidaKT2440. Frontiers in Microbiology, 8:840.
(15)Zeng ZS^#, Cai XS^#, Wang PX, Guo YX, Liu XX, Li BY, Wang XX* (2017). Biofilm formation and heat stress induce pyomelanin production in deep-sea Pseudoalteromonas sp. SM9913. Frontiers in Microbiology, 8:1822.
(16)Wen ZL^#, Wang PX^#, Sun CL, Guo YX, Wang XX* (2017). Interaction of type IV toxin/antitoxin systems in cryptic prophages of Escherichia Coli K-12. Toxins, 9:77.
(17)郭云学, 李百元，王晓雪* (2017). 细菌的毒素-抗毒素系统:定时炸弹还是免死金牌, 微生物学报, 57(11): 1708-1715.
(18)Guo YX^#, Yao JY^#, Sun CL, Wen ZL, Wang XX* (2016). Characterization of the Deep-SeaStreptomyces sp. SCSIO 02999 Derived VapC/VapB Toxin-Antitoxin System inEscherichia coli.Toxins 8: 195.
(19)Zeng ZS, Liu XX, Yao JY, Guo YX, Li BY, Li YM, Jiao NZ,Wang XX* (2016). Cold adaptation regulated by cryptic prophage excision inShewanella oneidensis.The ISME Journal, 10(12): 2787.
(20)Yao JY^#, Guo YX^#, Zeng ZS, Liu XX, Shi F, Wang XX* (2015). Identification and characterization of a HEPN-MNT family type II toxin–antitoxin in Shewanella oneidensis. Microbial Biotechnology 8 (6): 961-973.
(21)Liu XX, Li YM, Guo YX, Zeng ZS, Li BY, Wood TK, Cai XS, Wang XX (2015). Physiological function of Rac prophage during biofilm formation and regulation of Rac excision in Escherichia coli K-12. Scientific Reports, 5:16074, DOI: 10.1038/srep16074.
(22)Guo YX, Quiroga C, Chen Q, McAnulty M J, Benedik M J, Wood TK*, Wang XX* (2014). RalR (a DNase) and RalA (a small RNA) form a type I toxin-antitoxin system in Escherichia coli. Nucleic Acids Research 42 (10): 6448-6462.
(23)Guo YX, Chen YS, Zhang Y, Zhang Y, Chen LX, Mo DL* (2012). Up-regulated miR-145 expression inhibits porcine preadipocytes differentiation by targeting IRS1. International Journal of Biological Sciences 8(10): 1408-1417.
(24)Guo YX^#, Mo DL^#, Zhang Y, Zhang Y, Cong PQ, Xiao SQ, He ZY, Liu XH, Chen YS. MicroRNAome comparison between swine intramuscular and subcutaneous vascular stem cells adipogenesis. PLoS ONE 2012, 7(9): e45410.
(25)郭云学，郭云学, 莫德林, 陈瑶生, 张悦, 张云, 刘晓红 (2012). PI3K/AKT抑制剂渥曼青霉素对猪前体脂肪细胞增殖和凋亡的影响, 遗传 34(10):1282-1290.
(26)Guo YX, Dong XX*, Tan BP, Chi SY, Yang QH, Chen G, Zhang L (2011). Partial replacement of soybean meal by sesame meal in diets of juvenile Nile tilapia, Oreochromis niloticus L. Aquaculture Research 42(9): 1298-1307.
(27)Dong XX*, Guo YX, Ye JD, Song WD, Huang XH, Wang H (2010). Apparent digestibility of selected feed ingredients in diets for juvenile hybrid tilapia, Oreochromis niloticus×Oreochromis aureus. Aquaculture Research 41: 1356-1364.