PI：曾子晏(曾用名曾骥孟)执行主任、教授级高级工程师、博士生导师

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个人简介：
曾子晏博士，教授级高级工程师，博士生导师，主要研究方向为药物基因组学及个体化诊疗研发，涉及脑白质疏松症(Leukoaraiosis)、腺癌(adenocarcinoma)、不孕症(A-/Oligo-zoospermia) 及间充质干细胞(MSC)的扩增等多个领域，曾在国际学术期刊发表SCI/IEEE学术论文40余篇，申报4项PCT专利，9项中国发明专利，并开发出超过六项生技市场产品，对生物医药技术的研发、转化商品应用、市场与资本运作等方面均有丰富的实践经验。于厦大任职期间承担国家自然科学基金两项，省市级科技项目四项。引领的药学院转化医学平台期间合作建立了标准化的生物样本资源库并开展了多项基于高通量芯片技术（甲基化芯片、表达谱芯片、小RNA芯 片等）的研究，先后与福建肿瘤医院，厦门中山医院，厦门第一医院合作，并联合台北病理中心，台大医学院基因蛋白组中心，筛选出甲状腺癌、乳腺癌、胃癌、癫 痫、脑白质疏松症、少精无精等多种疾病中的关键基因和潜在靶向治疗生物标志物进行基础研究。且与佰香汇生技，艾德生医药、上海逍鹏、台湾芮宝生化、山东铂 源等多家生物医学产业公司合作，将科研成果转化到市场中，将开发出相关检测类试剂盒（EGFR, SMA, VitD3, PD等检测试剂盒）及医药产品(Terpenoid vs Psoriasis牛皮鲜, Osteoporosis骨质疏松vs Protosand MSC间充质干细胞vs wound healing伤口愈合)，充分实现了产学研相结合概念与产业化。
2012年获厦门市引进高层次人才“双百计划”领军型创业人才称号，厦门大学2013优秀教师，为霍英东基金评审专家，厦门市科技局评审专家，国家自然科学基金评审专家，国家火炬科技园招商与技术顾问，福建省及厦门市医疗器械体外诊断试剂类专家委员。

教育经历：
1989.06-1993.05：台湾清华大学原子科学院，辐射生物博士；
1995.07-1996.06：美国斯坦福大学医学院，结构生物及免疫学博士后；
1996.07-1999.07：美国斯坦福大学医学院，生物化学博士后。

代表性论文：
Congxia LU，Qing Lin,Wenqing Huang, Tzeng CM*. Novel polymorphisms in ATP7B, identified in sporadic Wilson’s disease. European Journal of Medical Genetics. 2014 XXX(in press, IF:1.925)

YQ Wang, JJ Song, X Han, YY Liu, XH Wang，ZM Li，Tzeng CM*. Effects of angiopoietin-1 on inflammatory injury in endothelial progenitor cells and blood vessels,Current Gene Therapy, 2014. XXX(in press, IF: 5.318)
Zhiming Li, Qing Lin, Qilin Ma, Congxia Lu，Tzeng CM*. Genetic Predisposition to Parkinson’s disease and Cancer. Current cancer drug targets, 2014,14(3):XXX.(in press, IF: 4.00)

Hui-Ming Ye,Yi-Zhuo Lu,Xian-Ming Liang,Yong-Zhi Lin ,Yi Li, Zhong-Ying Zhang, Tzeng CM*.Clinical significance of combined testing of YKL-40 with CEA in Chinese colorectal cancer patients.Clinical Laboratory.2014, 60:XXX (in press, IF: 0.9)

Qilin Ma, Xingkai An, Zhiming Li, Huanjing Zhang, Wenqing Huang, Liangliang Cai, Peng Hu, Qing Lin*, Tzeng CM*. P268S in NOD2 associates With susceptibility to Parkinson's disease in Chinese Population.Behavioral and Brain Functions.2013,9:19(IF:2.13)

Xiao Nan Lv, Zhu Jun Liu, Huan Jing Zhang, Tzeng CM*.Aromatherapyon Central Nerve System(CNS): Therapeutic mechanism and its associated genes.CurrentDrug Targets.2013,14(8):872-879 (IF: 3.553)

Cai, Liang Liang, HuiMing Ye, Xiao Nan Lv, Yun Long Wu, HuanJing Zhang,Li Mou Zheng and Tzeng CM*. 25-(OH)-VitD3, as a Risk Indicator in Diagnosis of Adenocarcinoma.Current Drug Targets.2013,14(11):1367-76.(IF: 3.553 )

HL Zhang, L Ruan,LM Zheng, Daivid Whyte, Tzeng CM, XW Zhou. Association between class III β-tubulin expression and response to paclitaxel/vinorbine-based chemotherapy for non-small cell lung cancer: A meta-analysis.Lung cancer.2012,77(1):9-15. (IF: 3.6)

Guoyan Liu,Kunhong Liu,Yin Li, Chao Pan, Jiqin Su,Hongfeng Liao,Renxiang Yv, Zhaohui Li, Li Yuan, Huanjing Zhang, Tzeng CM*. Novel cancerization marker,TP53, and its role in distinguishing normal tissue adjacent to cancerous tissue from normal tissue adjacent to benign tissue. World Journal of Surgical Oncology.2012,10:252. (IF: 1.12)
SK Chiu, JT Ma, MH, Hsieh, DL, Lu and Tzeng CM*. Unique Marker Finder Algorithm Generates Molecular Diagnostic Markers.Int. J. Bioinformatics. 2011,7(1): 24-42.(IF: 0.102)

C.C. Chen,WC Ku,SK Chiu, Tzeng CM*.Deoxyribonucleic acid hybridization acceleration by photovoltaic effect. Appl.Phys.Lett.2006，89(23): 233902-1-2. (IF: 4.184)

Tsai, NP, Wu, YC, Chen, JW, Wu, CF, Tzeng CM*, Syu, WJ*. Multiple functions of l0036 in the regulation of the pathogenicity island of enterohaemorrhagic Escherichia coli O157 : H7. Biochemical Journal. 2006,393(Pt 2):591-9. (IF: 6.10)

E Lin,Y Hwang and Tzeng CM*.A Comparison of Taiwanese and Han Chinese Populations Based on Pharmacogenomics of Antidepressants with HapMap Database. J Hum Genet. 2006, 367:1177-1182. (IF: 3.68)
E Lin,Y Hwang and Tzeng CM* A Case Study of the Utility of the HapMapDatabase for Pharmacogenomic Haplotype Analysis in the Taiwanese Population. Molecular Diagnosis &Therapy. 2006, 10(6): 367-370. (IF: 3.45)

B Jiang,ZZ Zhu,F Liu,LF Hou, J Gu, E Chen, Tzeng CM, G Zhu. Prevalence of Mutation in the Epidermal Growth Factor Receptor Gene in Chinese Patients with Non-small Cell Lung Cancer. Clinical Oncology.2006,18:635-639.(IF:2.798)
Shyur LF, Chen CH, Lo CP, Wang SY ,Kang PL, Sun SJ, Chang CA, Tzeng CM* and Yang NS*. Inductionof Apoptosisin MCF-7 Human Breast Cancer Cells by Phytochemicals from Anoectochilusformosanus. J. BioMedical Science.2004, 11(6): 928-939. (IF: 3.12)
Yang NS, Shyur LF, Chen CH, Wang SY and Tzeng CM*. Medicinal Herb Extract and a Single-Compound Drug Confer Similar Complex Pharmacogenomic Activities in MCF-7 Cells. J. BioMedical Science.2004, 11: 418-422. (IF: 3.12)
Chiu SK, Hsu M, Ku WC, Tu CY, YT Tseng YT, Lau WK, Yan RY, Ma JT, and Tzeng CM*. Synergistic effects of epoxy and amine-silanes on microarray DNA immobilization and hybridization. Biochemical J. 2003,374: 625-632. (IF: 6.10)
Hsieh, MH, Hsu, WC, Chiu, SK, Tzeng CM*. An efficient algorithm for minimal primer set selection. Bioinformatics.2003, 19(2):285-286. (IF: 2.259)
Lau, WK, Chiu, SK, Ma, JT, Tzeng CM*. Linear amplification of catalyzed reporter deposition technology on nylon membrane microarray. Biotechniques. 2002,33(3):564-570. (IF: 2.643)

Hsiu, F.M., Chen, S.J., Tsai, C.H., Tsou, C.Y., Su, Y.D., Lin, G.Y., Huang, K.T., Chyou, J.J., Ku, W.C., Chiu, S.K., Tzeng CM*. Surface plasmon resonance imaging system with Mach-Zehnder phase-shift interferometry for DNA micro-array hybridization; Multi- experiment linear data analysis for ATR biosensors. The Proceedings of SPIE.2002, 4819: 167-174/175-184.
Tzeng CM*, Kornberg, Arthur. The multiple activities of polyphosphate kinase of Escherichia coli and their subunit structure determined by radiation target analysis. Journal of Biological Chemistry.2000,275 (6): 3977-3983. (IF: 7.666 )
Tzeng CM*, Kornberg, A . Polyphosphate kinase is highly conserved in many bacterial pathogens. Molecular Microbiology. 1998,29 (1):381-382. (IF: 6.361 )
Ault-Riche D, Fraley CD, Tzeng CM, Kornberg A. (1998) Novel assay reveals multiple pathways regulating stress-induced accumulations of inorganic polyphosphate in Escherichia coli. J. Bacteriol. 180(7):1841-1847.(IF:3.712 )
Tzeng CM*, Percival, L, Barber, LD, Cooper, S, Adams, EJ, Stewart, D, Parham, P. HLA class I genotyping by cDNA sequence of a Vietnamese family expressing a weak B46 antigen. Tissue Antigens.1997,45 (9):519-522. (IF: 2.977)
Tzeng CM*, Adams EJ, Gumperz JE, Percival L, Wells RS, Parham P, Barber LD. Peptides bound endogenously by HLA-Cw*0304 expressed in LCL 721.221 cells include a peptide derived from HLA-E. Tissue Antigens. 1996, 48(4):325-328 (IF:2.977 )
Tzeng CM*, Yang CY, Yang SJ, Jiang SS, Kuo SY, Hung SH, Ma JT, Pan RL. Subunit structure of vacuolar proton-pyrophosphatase as determined by radiation inactivation. Biochem. J. 1996, 316(1):143-147 IF:4.349 )
Yang SJ, Jiang SS, Tzeng CM, Kuo SY, Hung SH, Pan RL. Involvement of tyrosine residue in the inhibition of plant vacuolar H(+)-pyrophosphatase by tetranitromethane. Biochim. Biophys. Acta. 1996,1294(1):89-97 (IF:2.590 )

Tzeng CM*, Pan RL. Chemical modification of tonoplast H+-ATPase from etiolated mung bean seedlings (Review). Bot. Bull. Acad. Sin. 1994, 35:1-6 (IF: 0.372 )
Hsu LH, Tzeng CM, Pan RL. Characterization of the phosphatase from spinach thylakoids. Bot. Bull. Acad. Sin. 1993, 34:175-182 (IF: 0.372 )
Chien LF, Wu JJ, Tzeng CM, Pan RL. ATPase of Rhodospirillum rubrum requires three functional copies of beta subunit as determined by radiation inactivation analysis. Biochem. Mol. Biol. Int. 1993,31(1):13-18 (IF:0.770 )
Ma JT, Wu JJ, Tzeng CM, Pan RL. Functional size analysis of F-ATPase from Escherichia coli by radiation inactivation. J. Biol. Chem. 1993,268(15):10802-7 (IF: 7.666)
Hsu LH, Tzeng CM, Pan RL. Functional size of the thylakoids phosphatase determined by radiation inactivation. FEBS Lett. 1993,318(1):1-3 (IF:3.720 )
Tzeng CM*, Hsu LH, Pan RL. Inhibition of tonoplast ATPase from etiolated mung bean seedlings by fluorescein 5’-isothiocyanate. Biochem J. 1992, 285(Pt 3):737-743 (IF:4.349 )

Chow, WM., Tzeng CM, Chen CS, Kuo SY, Wang MY, and Pan RL. Inhibition of tonoplast ATPase by 2',3'-dialdehyde derivative of ATP. Plant Physiol. 1992, 98: 44-52. (IF: 4.434)


中文：
吕晓楠、叶辉铭、顾龙、曾骥孟*.多重RT-PCR联合毛细管电泳法检测BCR-ABL融合基因.检验医学2014,03(9),227-233.
顾龙、肖芸、吕晓楠、叶辉铭、刘祝君、曾骥孟*.厦门大学附属中山医院2005～2012 年新发急性髓性白血病初步分析. 中华临床医师杂志2013,7(24):11388-11391.

李志明、安兴凯、林青、马琪林、曾骥孟*. 帕金森病LRRK2基因单核苷酸rs**：G＞A多态性分析.厦大学报2013,52(6).
张换敬，李怡，刘国彦，曾骥孟*. 新型靶向治疗HER2过表达乳腺癌. 广东医学. 2013.34(3):476-479.（影响因子:0.14）
李怡，张换敬, 吕晓楠, 刘国彦, 叶辉铭, 林青, 曾骥孟*. 生物样本信息资源库的国内外研究进展. 中国医药生物技术. 2012,7(5): 369-372.(影响因子:0.286).
曾骥孟.临床病毒学. 北京.科学出版社，2012.(2 chapters)
李怡，刘国彦，张换敬，郑立谋，曾骥孟*.新型环状引物荧光定量PCR检测乳腺癌组织HER2基因mRNA表达水平方法的建立. 中华检验医学杂志. 2012.35(11):1000-1005.（影响因子:0.916）
万巍巍,张换敬,叶辉铭,万丽琴,蔡良良,郑立谋,曾骥孟*.25-羟基维生素D3完全抗原的合成与鉴定.细胞与分子免疫学杂志. 2011,27(11): 1173-1179.




专利
曾骥孟*，吕晓楠，林辉暖，刘祝君，. 格列卫辅助治疗胃肠道间质瘤的用药选择及疗效检测试剂盒，厦门大学，CN7.5
曾骥孟*，吕晓楠，刘祝君，. 检测白血病BCR-ABL的多重RT-PCR试剂盒，厦门大学，CN7.X
刘祝君，曾骥孟，张换敬，吕晓楠. 一种去除精油中呋喃香豆素的方法. 厦门大学和佰香汇生物科技（厦门）有限公司联合申请. CN7.3.
刘祝君，曾骥孟，陈康，刘节喜，朱洪珍，郑声煊，谢加凤.. 一种新型连续精萃液态原料的超临界二氧化碳萃取技术. 厦门大学和佰香汇生物科技（厦门）有限公司联合申请CN3.8.
刘祝君，曾骥孟，陈康，刘节喜，朱洪珍，郑声煊，谢加凤.一种脱除柑橘属植物精油中呋喃香豆素类成分的新方法. CN7.3
曾骥孟*，郑立谋，万巍巍，蔡良良，吕晓楠，叶辉铭. 血液25-羟基维生素D3腺癌检测试剂盒及其制备方法.厦门大学. CN2.8.
郑立谋，张海龙，罗捷敏，阮力，周细武，曾骥孟*. 一种循环肿瘤细胞特异性富集方法. CN7.6.
刘祝君，曾骥孟，伍宏，陈康，郑声煊，朱洪珍，李煌基.一种新型长效固体芳香提的制作方法. 厦门大学和佰香汇生物科技（厦门）有限公司联合申请CN3.0
曾骥孟*，郑立谋，李怡，张换敬. 检测HER2基因表达水平的实时荧光定量PCR试剂盒. 厦门大学. ZL0.5
王蓟斌，张海龙，阮力，曾骥孟，郑立谋. 用于预测乙肝病毒引起的肝癌的引物、探针及试剂盒.厦门艾德生物医药科技有限公司2011: CN1.X
朱冠山，赵翊均，曾骥孟*. 非小细胞肺癌疗效相关的egfr基因突变的快速检测. 上海基康生物科技有限公司2007：CN8.0
Chi-chan Chen，Wei-chi Ku，Sung-kay Chiu，Chi-meng Tzeng*. Photovoltaic device to accelerate the interaction among biomolecules. U-Vision Biotech Co.,Ltd. WO.
Chi-meng Tzeng*, Kung-ming Hsu,Wei-chi Ku,Grace Lau, Jing-tyan Ma and Sung-kay Chiu. Combination of epoxy and amine silanes for immobilizing and hybridizing nucleic acid molecules on a solid support. U-Vision Biotech Co.,Ltd. US.
Shean-jen Chen,Feng-ming Hsiu,Chien-hung Tsai,Chia-yuan Tsou and Chi-meng Tzeng*. Surface plasmon resonance shifting interferometry imaging system for biomolecular interaction analysis. U-Vision Biotech Co.,Ltd. US.
Chi-chan Chen，Sung-kay Chiu,Chi-meng Tzeng and Wei-chi Ku. Photovoltaic device to accelerate the interaction among biomolecules. U-Vision Biotech Co.,Ltd..US.


团队成员
林青、叶辉铭、张换敬、胡鹏、黄文清、李怡、李志明、蔡良良、吕晓楠、雷茗杰、林辉暖、顾龙。

联系方式：
地址：福建省厦门市翔安区翔安南路厦门大学药学院259
邮编：361102

电话：

Email：cmtzeng@xmu.edu.cn