陈登岳博士、助理教授

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研究成果：
陈登岳博士主要从事纳米药物的新型可控制备与聚合物包覆技术及缓控释给药系统的研究工作。2008年于天津大学化工学院获得工学学士学位，2010年获得北京交通大学理学硕士学位，同年赴美New Jersey Institute of Technology开展博士课题研究，与BMS（百事美施贵宝）公司合作开发新型连续性制药器件。2015年获得工学博士学位，同年进入Shire生物制药公司美国总部担任研发科学家，从事成品药物QbD（质量源于设计）体系的设计优化工作。近5年来共发表SCI文章23篇，其中以第一作者或通讯作者共发表了18篇文章（6篇为JCR一区，另12篇为JCR二区），专利6项，目前主持国家基金1项、省基金1项、教育部专项基金3项。
基金项目：
1. 中国国家自然基金青年项目，微纤维管束结晶器内聚合物包覆纳米药物晶体的可控制备（**），2018.1-2020.12，21****民币，主持。
2. 福建省自然基金青年项目，新型多孔微膜丝结晶器内纳米载药脂质体的可控制备（2018J05143），2018.4-2021.4，3****民币，主持。
3. 中央高校基本科研业务费专项，微流控可控制备自组装无载体纳米药物用于肿瘤光化学联合治疗与多模式成像诊疗一体化研究，2020.8-2021.8，10****民币，主持。
4. 中央高校基本科研业务费专项，基于计算流体力学的新冠病毒传播机制与防护措施的机理研究（），2020.2-2020.12，10****民币，主持。
5. 中央高校基本科研业务费专项，快速冷却微膜丝结晶器内连续可控生产聚合物包覆的纳米药物晶（），2019.1-2019.12，25****民币，主持。
6. 美国国家自然科学基金项目，GOALI: Continuous coating of ultrafine drug particles by heterogeneous polymer nucleation in a hollow fiber membrane module，2011/01-2013/12，30万美金，已结题，主要参与人。
第一或通讯作者发表论文：
1. Liu C, Liu Q, Chen L, Li M, Yin J, Zhu X*, Chen D*.A pH-sensitive Self-assembled and Carrier-free Nanoparticle Based on Charge-reversal for Enhanced Synergetic Chemo-phototherapy. Advanced Healthcare Materials.2020, 9, **.（通讯作者, IF= 7.367, JCR一区）
2. Zuo W¹, Chen D¹, Fan Z, Chen L, Zhu Z, Zhu Q, Zhu X*. Design of Light/ROS Cascade-Responsive Tumor-Recognizing Nanotheranostics for Spatiotemporally Controlled Drug Release in Locoregional Photo-Chemotherapy. Acta Biomaterialia.2020, 111, 327-340. （共同第一作者, IF= 7.242, JCR一区TOP）
3. Gao X, Wang B,Liu Q, Liu C, Li M, Sirkar K K*, Chen D*.Fluid Dynamic and Heat Transfer Simulations of Solid Hollow Fiber Cooling Crystallizer for Continuous Synthesis of Drug Nanoparticles. Crystal Growth & Design. 2020, 20, 6, 4020–4029. （通讯作者, IF=4.089, JCR一区TOP）
4. Ma J¹, Chen D¹, Li Y, Chen Y, Liu Q, Zhou X, K. Qian, Li Z, Ruan H, Hou Z, Zhu X*. Zinc phthalocyanine-soybean phospholipid complex based drug carrier for switchable photoacoustic/fluorescence image, multiphase photothermal/ photodynamic treatment and synergetic therapy. Journal of Controlled Release, 2018, 284:1-14.（共同第一作者, IF= 7.727, JCR一区TOP）
5. Chen D¹, Wang B¹, Sirkar K K*. Hydrodynamic modeling of porous hollow fiber anti-solvent crystallizer for continuous production of drug crystals. Journal of Membrane Science, 2018, 556, 185-195.（第一作者, IF=7.183, JCR一区TOP）
6. Zhou X, Zhu X, Wang B, Li J, Liu Q, Gao X, Sirka K K*, Chen D*, Continuous production of drug nanocrystals by porous hollow fiber-based anti-solvent crystallization,Journal of Membrane Science, 2018,564,682-690.（通讯作者, IF=7.183, JCR一区TOP）
7. Liu Q¹, Zhu X¹, Wang B, Zhou X, Liu C, Gao X, Sirkar K K*, Chen D*, Continuous synthesis of drug nanocrystals by solid hollow fiber cooling crystallization,International Journal of Pharmaceutics,2020, 576, 118978.（通讯作者, IF= 4.845, JCR二区TOP）
8. Chen Y, Chen Q, Zhu Q, Liu J, Li Y, Gao X, Chen D*, Zhu X*. Small Molecular Theranostic Assemblies Functionalized by Doxorubicin–Hyaluronic Acid–Methotrexate Prodrug for Multiple Tumor Targeting and Imaging-Guided Combined Chemo-Photothermal Therapy, MolecularPharmaceutics, 2019, 16, 2470-2480. （通讯作者, IF= 4.321, JCR二区）
9. Zhao D, Song H,Zhou X, Chen Y, Liu Q, Gao X, Zhu X*,Chen D*. Novel facile thermosensitive hydrogel as sustained and controllable gene release vehicle for breast cancer treatment. European Journal of Pharmaceutical Sciences, 2019, 134, 145-152. （通讯作者, IF= 3.616, JCR二区）
10. Jin C¹, Chen D¹, Pfeffer R, Sirkar K K*. An extended duration operation for solid hollow fiber membrane-based cooling crystallization. Powder Technology, 2020, 365, 106-114.（第一作者, IF= 4.142, JCR二区）
11. Zhou X, Wang B, Liu Q, Liu C, Gao X,Sirkar K K*, Chen D*. An Extended Duration Operation for Porous Hollow Fiber-Based Antisolvent Crystallization, Industrial & Engineering Chemistry Research. 2019, 58, 12431?12437. （第一作者, IF= 3.573, JCR二区TOP）
12. Ma J, Wu H, Li Y, Liu Z, Liu G, Guo Y, Hou Z, Zhao Q, Chen D*, Zhu X*. Novel Core-Interlayer-Shell DOX/ZnPc Co-loaded MSNs@ pH-Sensitive CaP@PEGylated Liposome for Enhanced Synergetic Chemo-Photodynamic Therapy, Pharmaceutical Research, 2018, 35(3):57.（通讯作者, IF= 3.242, JCR二区）
13. Chen D, Sirkar K K*, Jin C, Dhananjay S, Pfeffer R. Membrane-based Technologies in the Pharmaceutical Industry and Continuous Production of Polymer-coated Crystals/Particles, Current Pharmaceutical Design, 2017, 23(2):242-249. （第一作者, IF= 2.208, JCR三区）
14. Chen D, Singh D, Sirkar K K*, Pfeffer R. Continuous preparation of polymer coated drug crystals by solid hollow fiber membrane-based cooling crystallization.International Journal of Pharmaceutics, 2016, 499(1), 395-402.（第一作者, IF= 4.845, JCR二区TOP）
15. Chen D, Singh D, Sirkar K K*. Continuous synthesis of polymer coated drug particles by a porous hollow fiber membrane-based anti-solvent crystallization method.Langmuir, 2015, 31, 432-441.（第一作者, IF= 3.557, JCR二区TOP）
16. Chen D, Singh D, Sirkar K K*. Porous hollow fiber membrane-based continuous technique of polymer coating on submicron and nanoparticles via anti-solvent crystallization. Industrial & Engineering Chemistry Research, 2015, 54(19), 5237-5245.（第一作者, IF= 3.573, JCR二区TOP）
17. Chen D, Singh D, Sirkar K K*. Continuous polymer nanocoating on silica nanoparticles.Langmuir, 2014, 30, 7804-7810.（第一作者, IF= 3.557, JCR二区TOP）
18. Chen D, Singh D, Sirkar K K*. Continuous polymer coating/encapsulation of submicron particles using a solid hollow fiber cooling crystallization method,Industrial & Engineering Chemistry Research, 2014, 53(15), 6388-6400.（第一作者, IF= 3.573, JCR二区TOP）
非第一或通讯作者发表论文：
19. Li Y, Lin J, Ma J, Song L, Lin H, Tang B, Chen D, Su G, Ye S, Zhu X, Luo F*, Hou Z*. Methotrexate-Camptothecin Prodrug Nanoassemblies as a Versatile Nanoplatform for Biomodal Imaging-Guided Self-Active Targeted and Synergistic Chemotherapy, ACS Applied Materials & Interfaces, 2017,9(40), 34650-34665.（第七作者, IF= 8.758, JCR一区TOP）
20. Li Y, Liu G, Ma J, Lin J, Lin H, Su G, Chen D,Ye S, Chen X, Zhu X, Hou Z.Chemotherapeutic drug-photothermal agent co-self-assembling nanoparticles for near-infrared fluorescence and photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy,Journal of Controlled Release, 2017, 258:95-107.（第七作者, IF= 7.727, JCR一区TOP）
21. Li Q, Chen Y, Zhou X, Chen D, Li Y, Yang J*, Zhu X*.Hyaluronic Acid-Methotrexate Conjugates Coated Magnetic Polydopamine Nanoparticles forMultimodal Imaging-Guided Multistage Targeted Chemo-Photothermal Therapy, Molecular Pharmaceutics, 2018, 15(9), 4049-4062.（第四作者, IF= 4.321, JCR二区）
22. Ma J, Li Y, Liu G, Li A, Chen Y, Zhou X,Chen D, Hou Z*, Zhu X*.Novel theranostic zinc phthalocyanine–phospholipid complex self-assembled nanoparticles for imaging-guided targeted photodynamic treatment with controllable ROS production and shape-assisted enhanced cellular uptake, Colloids And Surfaces B-Biointerfaces, 2018, 162,76-89.（第七作者, IF= 4.389, JCR二区）
23. Wang Z, Guo K, Liu H*, Liu C, Geng Y, Lu Z, Jia B, Chen D. Effects of bubble size on the mass transfer of bubble swarms with Sauter mean diameters of 0.38–4.88 mm in a co-current up-flow bubble column, Journal of Chemical Technology and Biotechnology.https://doi.org/10.1002/jctb.6445. （第八作者，IF= 2.75, JCR 三区）
专利:
1. 申请日: 2017年 02月 22日，申请号: 20**，发明名称:“用实壁纤维管束结晶器制丙烯酸树脂包覆纳米药物的方法”
2. 申请日: 2017年 02月 22日，申请号: 20**，实用新型名称:“丙烯酸树脂包覆纳米药物的制备装置”
3. 申请日: 2017年 02月 22日，申请号: 20**，发明名称:“聚合物包覆纳米药物制备装置与制备方法”
4. 申请日: 2017年 02月 22日，申请号: 20**，实用新型名称:“一种聚合物包覆纳米药物制备装置”
5. Kamalesh K Sirkar(#), Robert Pfeffer, Dhananjay Singh ,Dengyue Chen , System and method for continuous polymer coating of particles.2015.5.7 ,美国, US: 3:A.
6. Kamalesh K Sirkar(#), Robert Pfeffer, Dengyue Chen, Dhananjay Singh, Porous hollow fiber anti-solvent crystallization-based continuous method of polymer coating on submicron and nanoparticles.2016.6.16 ,美国, US: 6:A.
联系方式：
电子邮件：dchen@xmu.edu.cn