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个人简介
谢静静，女，研究生导师，2015年获福州大学生物化工博士学位，同年应聘为厦门大学药学院助理教授；主要从事以核受体靶点药物为基础的纳米药物传递系统设计、功能化纳米材料制备及生物安全性评估等在癌症诊断、治疗及转移预防方面的基础应用研究。近年来在Adv. Funct. Mater、Theranostics、J Control Release、Biotechnol Adv、Chem Mater、Int J Pharmaceut、J Nanobiotechnol、Curr Drug Metab、Sci Rep、Biochem Pharmacol、Cancer lett、Cancer、Oncotarget等国际权威期刊累计发表SCI论文20篇。研究成果多次荣获福建省自然科学论文奖。目前主持国家自然科学基金1项，福建省自然科学基金1项，厦门大学校长基金1项（连续三年资助），完成校级专项资助基金1项，作为学术骨干参与国家自然基金项目多项。
教育背景
2010.09-2015.06，福州大学化学学院，生物化工博士
2015.09-至今，厦门大学药学院，助理教授

代表性论文
After 2015
1. Xie, J.^*; Xu, W.; Wu, Y.; Niu, B; Zhang, X^*. Macroporous organosilicon nanocomposites co-deliver Bcl2-converting peptide and chemotherapeutic agent for synergistic treatment against multidrug resistant cancer. Cancer Lett469 (2020) 340–354. (First and Corresponding author)
2. Ge, P.; Niu, B.; Wu, Y.; Xu, W.; Li, M; Sun, H.; Zhou, H.; Zhang, X.^*; Xie, J^*. Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety. Chem Eng J. 2019, https://doi.org/10.1016/j.cej.2019.123228. (Corresponding author)
3. Wu, Y.; Ge, P.; Xu, W; Li, M.; Kang, Q.; Zhang, X., Xie, J^*. Cancer-targeted and intracellular delivery of Bcl-2-converting peptide with functional macroporous silica nanoparticles for biosafe treatment. Mat Sci & Eng C108 (2020) 110386. (Corresponding author)
4. Dong, H.; Lu, B.; Wang, J.; Xie, J.; Liu, K.; Jia, L.; Zhuang, J^*.Polymerization-driven successive collapse of DNA dominoes enabling highly sensitive cancer gene diagnosis.Chem. Commun.,2019, 55, 14797-14800.
5. Xu, W.; Gao, X.; Ge, P.; Jiang, F.; Zhang, X.;Xie, J^*. Dendrimer-like mesoporous silica nanospheres with suitable surface functionality to combat the multidrug resistance. Int J Pharm2018, 553, 349-362. (Corresponding author)
6. Xu, W.; Ge, P.; Niu, B.; Zhang, X.; Liu, J.;Xie, J^*. Macroporous silica nanoparticles for delivering Bcl2-function converting peptide to treat multidrug resistant-cancer cells. J Colloid Interface Sci2018, 527, 141-150. (Corresponding author)
7. Dong, H.; Han, L.; Wang, J.;Xie, J.; Gao, Y.; Xie, F.; Jia, L. In vivo inhibition of circulating tumor cells by two apoptosis-promoting circular aptamers with enhanced specificity. J Control Release2018, 280, 99-112.
8. Lu, Y.; Lian, S.; Ye, Y.; Yu, T.; Liang, H.; Cheng, Y.; Xie, J.; Zhu, Y.; Xie, X.; Yu, S.; Gao, Y.; Jia, L. S-Nitrosocaptopril prevents cancer metastasis in vivo by creating the hostile bloodstream microenvironment against circulating tumor cells. Pharmacol Res2019, 139, 535-549.
9. Dong, H. Y.; Han, L. Y.; Wu, Z. S.; Zhang, T.; Xie, J. J.; Ma, J.; Wang, J.; Li, T.; Gao, Y.; Shan, J. W.; Sinko, P. J.; Jia, L. Biostable Aptamer Rings Conjugated for Targeting Two Biomarkers on Circulating Tumor Cells in Vivo with Great Precision. Chem Mater2017, 29, 10312-10325.
10. Wang, J.; Chen, J.; Zhu, Y.; Zheng, N.; Liu, J.; Xiao, Y.; Lu, Y.; Dong, H.;Xie, J.; Yu, S.; Shao, J.; Jia, L. In vitro and in vivo efficacy and safety evaluation of metapristone and mifepristone as cancer metastatic chemopreventive agents. Biomed Pharmacother 2016, 78, 291-300.
11. Cheng, Y. L.; Lu, Y. S.; Zhang, D. D.; Lian, S.; Liang, H. Y.; Ye, Y. Y.; Xie, R. Z.; Li, S. H.; Chen, J. H.; Xue, X. H.;Xie, J. J.; Jia, L. Metastatic cancer cells compensate for low energy supplies in hostile microenvironments with bioenergetic adaptation and metabolic reprogramming. Int J Oncol2018, 53, 2590-2604.
Before 2015
1. Xie, J. J.; Lu, Y. S.; Dong, H. Y.; Zhao, R. L.; Chen, H. N.; Shen, W. Y.; Sinko, P. J.; Zhu, Y. W.; Wang, J. C.; Shao, J. W.; Gao, Y.; Xie, F. W.; Jia, L. Enhanced Specificity in Capturing and Restraining Circulating Tumor Cells with Dual Antibody-Dendrimer Conjugates. Adv Funct Mater2015, 25, 1304-1313. (First author)
2. Xie, J.; Gao, Y.; Zhao, R.; Sinko, P. J.; Gu, S.; Wang, J.; Li, Y.; Lu, Y.; Yu, S.; Wang, L.; Chen, S.; Shao, J.; Jia, L. Ex vivo and in vivo capture and deactivation of circulating tumor cells by dual-antibody-coated nanomaterials. J Control Release2015, 209, 159-69. (First author)
3. Xie, J.; Dong, H.; Chen, H.; Zhao, R.; Sinko, P. J.; Shen, W.; Wang, J.; Lu, Y.; Yang, X.; Xie, F.; Jia, L. Exploring cancer metastasis prevention strategy: interrupting adhesion of cancer cells to vascular endothelia of potential metastatic tissues by antibody-coated nanomaterial. J Nanobiotechnol 2015, 13, (First author)
4. Xie, J.; Wang, J.; Chen, H.; Shen, W.; Sinko, P. J.; Dong, H.; Zhao, R.; Lu, Y.; Zhu, Y.; Jia, L. Multivalent conjugation of antibody to dendrimers for the enhanced capture and regulation on colon cancer cells. Sci Rep2015, 5, 9445. (First author)
5. Dong, H.; Yang, X.; Xie, J.; Xiang, L.; Li, Y.; Ou, M.; Chi, T.; Liu, Z.; Yu, S.; Gao, Y.; Chen, J.; Shao, J.; Jia, L. UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma. Biochem Pharmacol 2015, 93, 151-62.
6. Dong, H.; Wu, Z. S.; Xu, J.; Ma, J.; Zhang, H.; Wang, J.; Shen, W.; Xie, J.; Jia, L. Novel multifunction-integrated molecular beacon for the amplification detection of DNA hybridization based on primer/template-free isothermal polymerization. Biosens Bioelectron2015, 72, 182-90.
7. Lu, Y.; Liang, H.; Yu, T.; Xie, J.; Chen, S.; Dong, H.; Sinko, P. J.; Lian, S.; Xu, J.; Wang, J.; Yu, S.; Shao, J.; Yuan, B.; Wang, L.; Jia, L. Isolation and characterization of living circulating tumor cells in patients by immunomagnetic negative enrichment coupled with flow cytometry. Cancer2015, 121, 3036-45.
8. Wan, L.; Dong, H.; Xu, H.; Ma, J.; Zhu, Y.; Lu, Y.; Wang, J.; Zhang, T.; Li, T.; Xie, J.; Xu, B.; Xie, F.; Gao, Y.; Shao, J.; Tu, X.; Jia, L. Aspirin, lysine, mifepristone and doxycycline combined can effectively and safely prevent and treat cancer metastasis: prevent seeds from gemmating on soil. Oncotarget 2015, 6, 35157-72.
9. Xie, J.; Zhao, R.; Gu, S.; Dong, H.; Wang, J.; Lu, Y.; Sinko, P. J.; Yu, T.; Xie, F.; Wang, L.; Shao, J.; Jia, L. The architecture and biological function of dual antibody-coated dendrimers: enhanced control of circulating tumor cells and their hetero-adhesion to endothelial cells for metastasis prevention. Theranostics2014, 4, 1250-63. (First author)
10. Gao, Y.^#; Xie, J.^#; Chen, H.; Gu, S.; Zhao, R.; Shao, J.; Jia, L. Nanotechnology-based intelligent drug design for cancer metastasis treatment. Biotechnol Adv2014, 32, 761-77. (Co-First author)
11. Lu, Y.; Yu, T.; Liang, H.; Wang, J.; Xie, J.; Shao, J.; Gao, Y.; Yu, S.; Chen, S.; Wang, L.; Jia, L. Nitric oxide inhibits hetero-adhesion of cancer cells to endothelial cells: restraining circulating tumor cells from initiating metastatic cascade. Sci Rep2014, 4, 4344.
12. Xie, J.; Shao, J.; Lu, Y.; Chen, J.; Wang, J.; Yu, S.; Jia, L. Separation of ginseng active ingredients and their roles in cancer metastasis supplementary therapy. Curr Drug Metab 2013, 14, 616-23. (First author)
13. Shao, J.; Dai, Y.; Zhao, W.; Xie, J.; Xue, J.; Ye, J.; Jia, L. Intracellular distribution and mechanisms of actions of photosensitizer Zinc(II)-phthalocyanine solubilized in Cremophor EL against human hepatocellular carcinoma HepG2 cells. Cancer lett2013, 330, 49-56.

联系方式：
地址：福建省厦门市翔安区翔安南路厦门大学药学院509室
邮箱：xiejj@xmu.edu.cn